PhilArt vs Profhilo – Polynucleotides Compared

Last Updated On: June 19, 2025

Polynucleotides, long chains of nucleotides renowned for their regenerative properties, have gained significant momentum in the field of aesthetic medicine. These biostimulants are showing promise in enhancing tissue repair, skin rejuvenation, and hydration. Clinical trials have highlighted the positive impact of polynucleotide-based injectables in improving skin elasticity, hydration, and reducing wrinkle depth—though outcomes can vary depending on the specific formulation and treatment protocol.

As demand for biostimulatory treatments grows, products like PhilArt and Profhilo have gained attention as effective solutions for skin revitalization. While both are designed to restore skin vitality, their composition and mechanisms differ, making it important to understand their distinctions before making a decision.

In this article, we will compare PhilArt and Profhilo, explore their benefits, indications, and possible side effects, providing you with the essential information to make a well-informed choice when selecting the right treatment for your needs.

Key Takeaways

• PhilArt is a polynucleotide injectable that comes from ultra-purified salmon DNA. It can regenerate the skin deeply and provide long-term rejuvenation. It is ideal for treating advanced photoaging, deep wrinkles, scars, and skin thinning.
• Unlike traditional volumizing fillers, PhilArt focuses on restoring the natural quality of the skin, stimulating the production of collagen, elastin, and hyaluronic acid, resulting in firmer, smoother, and more radiant skin.
• Profhilo, a hyaluronic acid-based injectable, utilizes a NAHYCO complex to enhance hydration, elasticity, and overall radiance without adding volume, ideal for early signs of aging, dry skin, and mild skin laxity.
• PhilArt’s treatment protocol typically requires 2–3 sessions spaced 3–4 weeks apart, while Profhilo requires two sessions one month apart, with both offering maintenance sessions every 4–6 months.
• PhilArt involves more injection points per session due to its thicker consistency. At the same time, Profhilo uses five standardized injection points per side, based on the Bio Aesthetic Points (BAP) technique, for even diffusion.
• PhilArt is ideal for patients seeking structural rejuvenation and visible lifting, while Profhilo is best for those desiring quick hydration, a natural glow, and subtle lifting effects.
• Combining PhilArt and Profhilo can provide multi-layered skin enhancement, addressing both volume loss and moisture deficits, offering a comprehensive treatment plan for advanced aging concerns or mixed skin issues.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to buy Croma PhilArt Fillers online, contact our sales department for more information.  

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PhilArt Composition & Mechanism

PhilArt is a polynucleotide injectable derived from ultra-purified salmon DNA. Unlike traditional fillers that focus on volume, PhilArt targets skin regeneration, marking it as part of a new generation of biostimulatory treatments that restore the skin’s natural vitality over time.

It is especially effective for early aging, dullness, and even post-acne scarring. PhilArt works to enhance the skin’s intrinsic health and structure, promoting both cosmetic improvement and long-term skin health.

Composition Highlights

• Polynucleotides (PN): DNA fragments extracted from salmon sperm cells, known for their high biocompatibility and regenerative potential in stimulating collagen and elastin production.
• Free of Cross-Linked HA: Unlike volumizing fillers, PhilArt does not contain hyaluronic acid, reducing risks of puffiness or overcorrection often associated with HA-based injectables.
• Sterile and Injectable: Formulated for safe use in both aesthetic and dermatological settings, it’s typically administered via microinjection for precise delivery.
• Multi-Depth Versatility: Suitable for both intradermal or subdermal layers, allowing customization based on the specific issue being treated, whether wrinkles, scars, or dullness.

PhilArt stimulates fibroblasts, promoting the production of collagen, elastin, and hyaluronic acid within the skin, creating a healthier dermal environment. It also supports angiogenesis (the formation of new blood vessels) and reduces oxidative stress, which contributes to healthier, firmer, and more radiant skin. 

These mechanisms deliver visible improvements when used in a series of treatments spaced a few weeks apart.

Profhilo Formulation & Mode of Action

Profhilo is a unique injectable hyaluronic acid (HA) product based on a patented hybrid complex. Unlike polynucleotide-based treatments, Profhilo combines high- and low-molecular-weight hyaluronic acid to provide sustained hydration and promote tissue remodeling. 

Its goal is to naturally enhance skin firmness, elasticity, and radiance without adding volume, distinguishing it from traditional fillers that focus on plumping.

Composition Highlights

• NAHYCO Complex: A proprietary blend of high- and low-molecular-weight hyaluronic acid that enhances skin hydration, elasticity, and overall rejuvenation.
• Non-Crosslinked Formula: The non-crosslinked formula enables smooth diffusion through the dermis, ensuring uniform skin rejuvenation rather than localized plumping, which is ideal for achieving a natural-looking result.
• Biocompatible and Biodegradable: Safe for various skin types, Profhilo carries a minimal risk of adverse reactions, making it a well-tolerated option for many patients.
• Standardized Injection Protocol: Typically administered using the Bio Aesthetic Points (BAP) technique, which involves strategically placing the product at five points on each side of the face to achieve natural lift and even distribution.

Profhilo works by stimulating the skin’s natural production of collagen and elastin, which results in firmer, more elastic skin over time. The initial lifting and tightening effect is noticeable within 1–2 weeks, followed by gradual improvements in skin texture and hydration that last several months.

Treatment Protocols: PhilArt vs Profhilo

Understanding the differences in treatment protocols between PhilArt and Profhilo is crucial for determining the best approach for each patient’s unique skin needs. These injectables have distinct regimens and techniques, reflecting their unique composition and intended results.

PhilArt treatments typically require more injection sites per session due to its thicker consistency and its focus on deeper reparative actions. Profhilo, on the other hand, uses fewer injection points based on the BAP technique, which maximizes gel diffusion for overall hydration and tightening.

Both protocols are designed to deliver optimal results, with maintenance sessions to prolong the benefits. Consulting with a trained professional will help determine which approach, or a combination of techniques, suits your specific skin goals.

PhilArt vs Profhilo: Patient Selection & Indications

Choosing between PhilArt and Profhilo depends on your skin condition, aging concerns, and desired outcomes. Below is a breakdown to clarify which injectable is best suited for which patient profile:

Who Should Consider PhilArt?

PhilArt products are ideal for patients looking for deeper skin repair and long-term rejuvenation. They are particularly effective for:

• Advanced Photoaging: Ideal for skin with significant sun damage, deep wrinkles, and uneven texture.
• Deep Wrinkles and Scars: Helps smooth out scars and soften pronounced lines by promoting collagen and elastin synthesis.
• Loss of Skin Thickness: Restores volume and dermal density, improving overall skin firmness.
• Rejuvenation & Tissue Strengthening: Combines hydration with structural repair for improved skin resilience over time.

PhilArt is recommended for patients who desire both immediate skin improvement and sustained tissue regeneration, making it ideal for moderate to severe signs of aging.

Who Should Opt for Profhilo?

Profhilo focuses primarily on hydration and elasticity and is best suited for:

• Early Signs of Aging: Targets mild wrinkles and fine lines before they deepen.
• Dry or Dehydrated Skin: Provides an immediate moisture boost to revitalize dull, parched skin.
• Mild Skin Laxity: Tightens and lifts slightly sagging skin with minimal discomfort or downtime.
• Natural Glow & Radiance: Enhances overall skin tone and texture, promoting youthful luminosity.

Profhilo is ideal for patients seeking a quick, noticeable glow and subtle lifting effects without the invasiveness of traditional fillers.

Combining PhilArt and Profhilo for Comprehensive Care

For patients looking to maximize the benefits of skin treatments, combining PhilArt and Profhilo can offer a comprehensive solution:

• Multi-Layered Skin Enhancement: PhilArt targets deeper structural repair while Profhilo provides surface-level hydration and tightening.
• Smoothing, Lifting, and Strengthening: The combination addresses both volume loss and moisture deficits, offering a well-rounded treatment approach.
• Customized Treatment Plans: A skilled practitioner can tailor session timing and dosages to ensure optimal, lasting results.

This combined approach is especially beneficial for patients with mixed concerns, such as moderate wrinkles accompanied by dryness, or those seeking a comprehensive skin quality upgrade.

Conclusion

Both PhilArt and Profhilo are effective skin boosters, each offering unique strengths tailored to different needs. PhilArt treatments are designed to promote deep tissue regeneration and long-lasting repair, making them ideal for individuals seeking structural rejuvenation and visible lifting, particularly in cases of advanced aging or skin damage.

On the other hand, Profhilo emphasizes rapid hydration and improvement of skin texture and radiance, providing a quick and noticeable glow with a mild lifting effect. It is particularly suited for those with early signs of aging or dry skin. Consulting with a licensed practitioner is crucial to determine which treatment best aligns with your skin type, goals, and aesthetic plan.

FAQs

1. Are PhilArt and Profhilo safe?

Yes, both are derived from biocompatible materials and show firm safety profiles in clinical settings.

2. How long will it take to see results?

PhilArt typically shows visible improvement after 4–6 weeks, while Profhilo delivers visible lift and moisture within 1–2 weeks.

3. Can PhilArt and Profhilo be combined?

Yes—stylistic layering is typical: Profhilo for hydration, PhilArt for deeper structural improvement.

4. How long do results last?

PhilArt effects last about 6–9 months with maintenance, while Profhilo often maintains results for 4–6 months between sessions.

References

Rho NK, Han KH, Cho M, Kim HS. A survey on the cosmetic use of injectable polynucleotide: The pattern of practice among Korean Dermatologists. J Cosmet Dermatol. 2024;23(4):1243-1252. doi:10.1111/jocd.16125

Lee KWA, Chan KWL, Lee A, et al. Polynucleotides in Aesthetic Medicine: A review of current practices and Perceived effectiveness. International Journal of Molecular Sciences. 2024;25(15):8224. doi:10.3390/ijms25158224

Ahmadi M. The efficacy of polynucleotide injections in aesthetic medicine: a review. The PMFA Journal. https://www.thepmfajournal.com/features/features/post/the-efficacy-of-polynucleotide-injections-in-aesthetic-medicine-a-review