BELOTERO®

Why Healthcare Professionals Choose BELOTERO®

The primary reason practitioners select BELOTERO® over other HA fillers is CPM® technology (Cohesive Polydensified Matrix), the proprietary manufacturing process that defines the range. CPM® produces a gel with heterogeneous density zones: areas of higher and lower crosslinking within the same matrix. This structure allows BELOTERO® to integrate into the dermal space without creating visible ridging, product show-through, or the Tyndall effect, which is the bluish discoloration that can appear when conventional HA fillers are placed too superficially in thin-skinned areas. For practitioners treating the tear trough and periorbital region, where skin is thin and product visibility is a real clinical concern, this integration behavior is a meaningful advantage. [3] BELOTERO® fillers are available in multiple formulations — explore the full dermal fillers category for more information.   A second differentiator is the range's genuine depth coverage. Rather than adapting a single gel consistency to different indications, Merz Aesthetics calibrates CPM® technology differently across each formulation. BELOTERO® SOFT is engineered for the most superficial tissue planes — areas where most fillers cannot be safely placed — while BELOTERO® VOLUME addresses deep subcutaneous volume loss. This product-matched approach gives practitioners a clinically specific option at each treatment depth, from the skin surface to structural correction.

Order BELOTERO® at Wholesale Prices

Licensed medical professionals seeking BELOTERO® wholesale pricing can contact the Med Supply Solutions team for current product availability, documentation, and account setup. Looking to buy BELOTERO® online? Get in touch with the team at Med Supply Solutions for guidance.

What Is BELOTERO® Used For?

The BELOTERO® range covers six core clinical indications. BELOTERO® SOFT and BELOTERO® BALANCE address fine lines and wrinkles, particularly in the perioral region and forehead, with SOFT's lighter formulation suited to the most superficial skin crepe. The LIPS CONTOUR and LIPS SHAPE formulations support lip augmentation, with CONTOUR focused on vermillion border definition and SHAPE on lip body volume. BELOTERO® VOLUME is used for cheek and temple volume restoration. Across all formulations, the cross-linked HA matrix also contributes a localized hydrating effect to treated tissue. Tear trough and periorbital correction is a particular area of clinical interest, with BELOTERO® BALANCE and BELOTERO® SOFT commonly selected due to CPM®'s superficial integration properties, which reduce the risk of the Tyndall effect in this anatomically demanding zone. The range is also used by experienced practitioners for hand rejuvenation, addressing age-related volume loss and skin thinning on the dorsal hands.

BELOTERO® Product Range

The BELOTERO® range is organized around treatment depth and correction type. BELOTERO® SOFT is the lightest formulation, placed in the superficial dermis for fine lines in the perioral region, forehead, and crow's feet. BELOTERO® BALANCE targets the mid dermis and is the most widely used product in the range, commonly selected for moderate lines such as nasolabial folds and marionette lines. BELOTERO® INTENSE is indicated for deeper dermal correction of pronounced folds and selected lip enhancement, while BELOTERO® VOLUME supports subcutaneous cheek and temple volume restoration. Within the dedicated LIPS sub-range, BELOTERO® LIPS CONTOUR addresses lip border and vermillion definition, and BELOTERO® LIPS SHAPE supports lip body volume and overall shape. Each product reflects a distinct clinical brief, with CPM® gel properties calibrated to the demands of its intended tissue plane.

BELOTERO® Treatment Areas

BELOTERO® is indicated across several facial zones, with each treatment area corresponding to a specific depth and formulation within the range.

• Superficial perioral lines, where BELOTERO® SOFT's shallow injection capability is uniquely appropriate, represent one of the range's most clinically specific applications, as few HA fillers can be safely placed at that level without risk of visibility or discoloration.
• Nasolabial folds and marionette lines are primary indications for BELOTERO® BALANCE, and the dedicated LIPS sub-range addresses lip volume and border definition as separate clinical objectives.
• For structural facial volume loss associated with age-related fat pad atrophy, BELOTERO® VOLUME is used in the cheeks and temples.
• The tear trough and under-eye area present particular technical demands: the overlying skin is thin, vascularly complex, and any product placed superficially is highly visible. CPM® technology's controlled dermal integration and the reduced Tyndall effect risk associated with BELOTERO® SOFT and BELOTERO® BALANCE make this range a clinically relevant choice for periorbital correction.
• Hand rejuvenation (addressing dorsal volume loss, visible tendons, and skin thinning) is an additional indication area for experienced practitioners.

About BELOTERO®

BELOTERO® is manufactured by Merz Aesthetics, a division of Merz Pharma GmbH & Co. KGaA, headquartered in Frankfurt, Germany. The company was founded in 1908, and BELOTERO® is its flagship HA filler brand. The range launched in Europe in 2005, and BELOTERO® BALANCE received FDA approval in the United States in November 2011. Since then, the portfolio has expanded to include the LIPS sub-range and additional formulations built on the CPM® platform. BELOTERO® is now available in more than 80 countries and is positioned as a precision option for superficial and delicate treatment areas. It sits alongside RADIESSE® fillers and Ultherapy® within Merz Aesthetics' broader aesthetic portfolio, offering practitioners complementary modalities where CPM®-specific properties are not the primary clinical driver. The CPM® process produces a polydensified gel with variable crosslinking density — a structure that supports tissue integration and reduces the likelihood of visible product-related discoloration in thin-skin applications.

BELOTERO® Safety Profile

BELOTERO® side effects are generally consistent with those of injectable HA fillers and are usually limited to the injection site or treatment area. Practitioners should review patient history, anatomy, product placement depth, and contraindications before treatment, particularly in superficial or vascularly sensitive areas. Common reactions may include pain, swelling, itching, redness, bruising, tenderness, firmness, or temporary discomfort. These effects are typically mild to moderate and resolve within a few days. Rare reactions may include nodules, allergic response, infection, delayed inflammation, or treatment-area irregularities. Persistent or worsening symptoms should be evaluated and documented appropriately. Severe complications are uncommon but may include skin blanching, severe pain, vision changes, stroke-related symptoms, or other signs of vascular compromise. Vision-related events are associated with inadvertent intravascular injection — practitioners should follow current injection safety guidelines and maintain complication-management protocols. BELOTERO® is contraindicated in patients with hypersensitivity to hyaluronic acid or any excipient. It is not intended for patients under 18, and caution is advised during pregnancy or breastfeeding. Because BELOTERO® is HA-based, results can be reversed with hyaluronidase when clinically appropriate.

BELOTERO® Regulatory Status

BELOTERO® BALANCE received FDA PMA approval on November 9, 2011, for the correction of moderate-to-severe nasolabial folds [1]. The broader BELOTERO® range carries CE Mark certification and is available across the European Union and in more than 80 countries globally. Manufacturing is conducted by Merz Pharma in accordance with ISO 13485 and current Good Manufacturing Practice (GMP) standards.

How Long Does BELOTERO® Last?

Results vary by product, generally ranging from six to eighteen months. BELOTERO® BALANCE typically lasts six to twelve months, while BELOTERO® VOLUME — placed at greater depth for structural correction — can maintain results for up to eighteen months. Touch-up intervals depend on the treatment area: the lips require more frequent maintenance due to constant movement, while cheek and temple corrections with BELOTERO® VOLUME tend to hold longer.

FAQs

1. What is CPM® technology and why does it matter?

CPM®, or Cohesive Polydensified Matrix, is the manufacturing process used to produce the BELOTERO® gel. It creates a structure with heterogeneous crosslinking density — zones of higher and lower crosslinking within the same matrix — which supports smoother dermal integration and may reduce the risk of the Tyndall effect when the product is placed in superficial tissue planes.

2. What is BELOTERO® used for?

BELOTERO® is used for fine lines, wrinkles, lip augmentation and definition, facial volume restoration, and tear trough correction. BELOTERO® SOFT and BELOTERO® BALANCE are particularly relevant for superficial and delicate areas, while experienced practitioners may consider hand rejuvenation in appropriate cases.

3. How long do BELOTERO® results last?

Results generally last 6 to 18 months depending on the product, treatment area, and individual patient factors. BELOTERO® BALANCE typically lasts 6 to 12 months, while BELOTERO® VOLUME may last up to 18 months. Higher-movement areas such as the lips may require more frequent touch-ups.

4. Is BELOTERO® suitable for tear trough treatment?

Yes. BELOTERO® is commonly considered for tear trough and periorbital correction because CPM® technology enables controlled dermal integration, while BELOTERO® SOFT is well-suited for shallow placement in this zone. As with any under-eye treatment, appropriate product selection, conservative technique, and current injection safety guidelines are essential.

5. Is BELOTERO® FDA approved?

BELOTERO® BALANCE received FDA PMA approval in November 2011 for the correction of moderate-to-severe nasolabial folds. [1] Other formulations in the BELOTERO® range are available under CE Mark certification outside the U.S.

6. Can BELOTERO® results be reversed?

Yes. Because BELOTERO® is hyaluronic acid-based, results can be reversed with hyaluronidase when correction, adjustment, or early dissolution is clinically appropriate.

7. Where can licensed professionals buy BELOTERO® online?

Licensed practitioners interested in BELOTERO® can contact the Med Supply Solutions team to discuss current availability, pricing, documentation, and wholesale account setup.

Citations

1. S. Food and Drug Administration. Premarket approval (PMA): P090016. U.S. Food and Drug Administration. Accessed June 24, 2026. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm?id=P090016
2. Merz Aesthetics — BELOTERO® Official HCP Information: https://www.belotero.com/ap/hcp/
3. Micheels P, Sarazin D, Besse S, Sundaram H, Flynn TC. A blanching technique for intradermal injection of the hyaluronic acid Belotero. Plast Reconstr Surg. 2013;132(4 Suppl 2):59S-68S. doi:1097/PRS.0b013e31829a02fb
4. Micheels P, Besse S, Sarazin D, Obamba M MS. Hyaluronic acid gel based on CPM^® technology with and without lidocaine: Is there a difference?. J Cosmet Dermatol. 2019;18(1):36-44. doi:10.1111/jocd.12803

For licensed healthcare professionals only. The content of this page is provided for informational purposes and does not constitute medical advice.