Restylane® is indicated for mid-to-deep dermal implantation for the correction of moderate to severe facial
wrinkles and folds, such as nasolabial folds. Restylane® is indicated for submucosal implantation for lip
augmentation in patients over the age of 21.

Restylane® is injected into the skin with an ultrafine needle to plump the skin to smooth away wrinkles and
folds such as the lines from your nose to the corners of your mouth (nasolabial folds) or your lips.

Restylane® effects generally last six months and gradually disappears from the body. If you are treated again at
4 ½ or 9 months after your first treatment, Restylane® can last up to 18 months.

Restylane® is a gel of hyaluronic acid generated by Streptococcus species of bacteria, chemically crosslinked
with BDDE, stabilized and suspended in phosphate buffered saline at pH=7 and concentration of 20 mg/mL.
Restylane® contains 0.3% lidocaine, a numbing substance, to increase comfort during treatment.

• Restylane® is indicated for mid-to-deep dermal implantation for the correction of moderate to severe facial
  wrinkles and folds, such as nasolabial folds.
• Injections of greater than 1.5 mL per lip (upper or lower) per treatment session significantly increases the
  occurrence of the total of moderate and severe injection site reactions.
• If a volume of more than 3 mL is needed to achieve optimal correction, a follow-up treatment session is
  recommended.

Contraindications:

• Restylane® is contraindicated for patients with severe allergies manifested by a history of anaphylaxis or
  history or presence of multiple severe allergies.
• Restylane® contains trace amounts of gram positive bacterial proteins, and is contraindicated for patients
  with a history of allergies to such material.
• Restylane® is contraindicated for patients with bleeding disorders.
• Restylane® is contraindicated for implantation in anatomical spaces other than the dermis or submucosal
  implantation for lip augmentation.

After-care:

• A cloth dipped in cold water (cold compress), wrung out, and applied to the injected area may be used
  immediately after treatment to reduce swelling.
• Avoid touching the treated area within six hours following treatment so you do not accidentally injure your
  skin while the area is numb. After that, the area can be gently washed with soap and water.
• Until there is no redness or swelling, avoid exposure of the treated area to intense heat (sun lamp or sun
  bathing).
• If you have previously suffered from facial cold sores, there is a risk that the needle punctures could
  contribute to another occurrence. Speak to your physician about medicine to prevent this from happening
  again.
• Avoid taking aspirin, non-steroidal anti-Inflammatory medications, St. John’s Wort, and high doses of Vitamin
  E supplements for one week after treatment. These agents may increase bruising and bleeding at the injection
  site.