David Fuller
Last Updated On: June 24, 2025
Polynucleotides, naturally occurring DNA fragments, are gaining popularity in regenerative aesthetics. A 2024 systematic review of nine studies involving 219 patients found significant improvements in skin hydration, elasticity, and overall texture. These treatments stimulate fibroblast activity, creating an environment conducive to collagen production, and aid in cell repair and reducing inflammation, making them promising solutions for aging and damaged skin.
One notable brand incorporating this science is PhilArt, a line of aesthetic products developed by Croma Pharma. PhilArt specializes in formulations designed to target delicate areas like the eyes and scalp, aiming to restore skin and hair vitality at the cellular level. By utilizing polynucleotide technology, these treatments provide effective rejuvenation without the downtime typically associated with more invasive procedures.
In this article, we’ll explore the full range of PhilArt products, including their mechanisms, treatment protocols, and what you can expect from therapies targeting the eye area, hair, and upcoming innovations in regenerative aesthetics.
About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to buy Croma PhilArt Fillers online, contact our sales department for more information.
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The core PhilArt product is a biostimulator made of polynucleotides at a concentration of 10 mg/mL (20 mg/2 mL). It is designed to revitalize the face, neck, and body areas that show early signs of aging. Unlike volumizing fillers, PhilArt works by stimulating fibroblast activity, enhancing collagen and elastin production, and improving the skin’s overall structure.
PhilArt improves skin quality without adding bulk or stiffness, making it ideal for dull skin, early wrinkles, acne scars, and skin laxity. Injections are administered intradermally or subdermally in multiple sessions spaced 2–3 weeks apart. Results generally begin to appear after the second session, with gradual improvements through subsequent treatments.
PhilArt Eye addresses common concerns in the periorbital region, such as under-eye bags, fine lines, and dark circles. The high-purity polynucleotides stimulate fibroblast activity, supporting collagen and elastin regeneration. Additionally, PhilArt Eye has anti-inflammatory properties that reduce puffiness, support skin hydration, and promote improved microcirculation, making it perfect for revitalizing tired-looking eyes.
PhilArt Hair targets mild to moderate hair thinning, including telogen effluvium and androgenetic alopecia in both men and women. It enhances the scalp environment by stimulating fibroblast activity, improving blood flow, and supporting collagen and elastin production.
Each vial of PhilArt Hair contains 15 mg/2 mL of purified polynucleotides, and treatment is administered intradermally using a microdroplet or fan technique. The product is distributed evenly across the scalp to rejuvenate hair follicles and improve overall scalp health.
Patients often report improved scalp hydration, reduced shedding, and the growth of baby hairs within 6–12 weeks. For visual results, prospective patients can look for PhilArt Hair before and after so they know what to expect from this treatment.
This can also complement treatments like PRP, microneedling, or post-hair transplant care, enhancing graft survival and healing.
PhilArt Next is the newest addition to Croma Pharma’s bio-revitalization portfolio, featuring enhanced formulations designed for deeper tissue regeneration. This includes a hybrid combination of polynucleotides and non-crosslinked hyaluronic acid/mannitol at 10 mg/mL to tackle deeper wrinkles, scars, and striae.
Croma Pharma is also exploring innovations such as customizable PN chain-lengths, dosing formats, and accelerated protocols to streamline clinical workflows. These advancements will provide clinicians with greater flexibility while improving patient satisfaction.
As the global shift toward regenerative and non-invasive solutions continues, PhilArt is well-positioned to lead in biostimulatory skin therapies. With PhilArt Next already available, the brand is pushing the boundaries of skin rejuvenation, preparing to meet the evolving needs of both clinicians and patients.
PhilArt products are revolutionizing the field of regenerative aesthetics, offering natural-looking improvements through bio-revitalization rather than artificial volume. From the delicate under-eye areas to the scalp, these polynucleotide-based formulations enhance skin tone, texture, and elasticity.
The versatility and safety of PhilArt make it a preferred choice among clinicians and patients alike. With continued product development and the launch of PhilArt Next, the brand is poised to redefine non-surgical rejuvenation across the face, body, and hair.
Polynucleotides (PNs) are DNA fragments that come from salmon sperm cells. They help regenerate skin by boosting collagen, repairing tissue, and reducing inflammation.
Yes, PhilArt Eye has high biocompatibility and a good safety profile. However, practitioners still recommend patch testing for patients who are very sensitive or those with fish allergies.
Initial scalp improvements (less shedding, improved hydration) may be visible after 3–4 sessions. For significant density improvements, the treatment requires a commitment of 2–3 months.
Yes, PhilArt integrates well with PRP, microneedling, HA fillers, and laser procedures. This multi-modal approach enhances results and long-term skin quality.
Webb WR, Rahman E, Rao P, et al. Points to ponder on the role of polynucleotides in regenerative and aesthetic medicine: a systematic review. Eur J Plast Surg. 2024;47(1):66. doi:10.1007/s00238-024-02209-x.
Lampridou S, Bassett S, Cavallini M, Christopoulos G. The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review. J Cosmet Dermatol. 2025;24(2):e16721. doi:10.1111/jocd.16721
Croma-Pharma introduces its newest injectable polynucleotide, PhilArt. Aesthetic Medicine. https://aestheticmed.co.uk/croma-pharma-introduces-its-newest-injectable
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