NUCLEOFILL™

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Why Practitioners Choose NUCLEOFILL™

NUCLEOFILL™ supports fibroblast activity and extracellular-matrix renewal to encourage collagen production and improve overall skin quality. It is not designed to restore projection or structural volume, and it differs from hyaluronic acid bio-remodelers, which act primarily through hydration and water binding. Practitioners can use it to address the appearance of texture, laxity, enlarged pores, and photodamage — either as a standalone protocol or alongside fillers and neurotoxins. [1][2] The range spans from Soft Plus, formulated with 0.75% polynucleotides, to Strong at 2.5%, giving practitioners flexibility to select a product based on the treatment area and severity of skin laxity. NUCLEOFILL™ Hair further broadens the portfolio with a formulation developed specifically for scalp protocols, an option not commonly found among traditional filler and bio-remodeling brands.[3]

What Is NUCLEOFILL™ Used For?

NUCLEOFILL™ polynucleotide products are used in practitioner-led bio-remodeling treatments that focus on skin quality rather than added volume. The specific concerns addressed depend on the formulation and may include fine lines, laxity, uneven texture, enlarged pores, and photodamage. Studies of injectable polynucleotides have reported improvements in hydration, elasticity, roughness, and pore appearance, although outcomes vary with the product, injection technique, treatment schedule, and individual response.[1][2] Practitioners may also consider polynucleotide protocols for patients with acne scarring and irregular skin texture. The range extends beyond facial rejuvenation through NUCLEOFILL™ Hair, which is formulated for scalp and hair-quality treatments.[1][3]

The NUCLEOFILL™ Product Range

NUCLEOFILL™ Soft Plus contains 15mg in a 2mL syringe (0.75% or 7.5mg/mL concentration). It is the lightest formulation, suited to superficial skin-quality treatment and delicate areas including the periorbital region. [2][3] NUCLEOFILL™ Medium contains 30mg in a 1.5mL syringe (2% or 20mg/mL concentration) — the mid-strength option for general facial skin bio-remodeling. [3] NUCLEOFILL™ Medium Plus contains 40mg in a 2mL syringe (2% or 20mg/mL concentration). It matches Medium in concentration but is packaged in a larger volume, suited to wider facial or body treatment areas and also used by practitioners in scalp and hair-quality protocols. [3] NUCLEOFILL™ Strong contains 37.5mg in a 1.5mL syringe (2.5% or 25mg/mL concentration). As the highest-concentration option, it is selected for more pronounced skin laxity or intensive protocols. [3] NUCLEOFILL™ Hair is a 2% polynucleotide gel developed specifically for scalp treatment, enabling clinics to add a dedicated hair-quality service to their offering. [3]

NUCLEOFILL™ Treatment Areas

Practitioners may incorporate NUCLEOFILL™ into protocols for the full face, periorbital and under-eye area, neck, décolletage, hands, scalp, and acne-scarred skin. Soft Plus is the preferred formulation for delicate areas; Hair is intended for scalp-focused treatment. [1][3] Because NUCLEOFILL™ targets skin quality rather than structural volume, it works well alongside hyaluronic acid fillers and botulinum toxin treatments — addressing texture and laxity as the skin-quality layer of a broader treatment plan.

How Long Does NUCLEOFILL™ Last?

NUCLEOFILL™ is typically used as a course of sessions spaced three to four weeks apart, with improvements building cumulatively. Based on available clinical literature, results last for up to 12 months in most patients, with some reporting longer durations depending on formulation, treatment area, protocol, and individual response. Maintenance may be considered at 12-month intervals or according to clinical assessment. [1][2]

NUCLEOFILL™ Safety Profile

Clinical studies of injectable polynucleotides generally report a low rate of serious adverse events, though treatment carries the risks associated with any injectable procedure. Expected local reactions may include temporary swelling, redness, bruising, tenderness, pain, or itching at the injection site. Less common complications include infection and allergic reaction. [1][2] Practitioners should screen for hypersensitivity to any product component, active infection or inflammation at the treatment site, pregnancy or breastfeeding, and autoimmune conditions requiring additional caution. NUCLEOFILL™ polynucleotides are derived from purified salmon DNA — fish-allergy screening is a relevant contraindication consideration that should be part of pre-treatment assessment. Product-specific instructions for use should guide formulation selection and treatment planning. [3]

Administration Technique

• Administer via intradermal or subdermal injection using a fine-gauge needle with multiple injection points across the treatment area.
• Massage the treated area after injection per product instructions.
• Follow product-specific instructions for use, including depth, volume, and injection spacing, by formulation.

NUCLEOFILL™ vs Other Skin Boosters

vs PROFHILO®

NUCLEOFILL™ and PROFHILO® are both used in skin-quality protocols, but they work through different pathways. PROFHILO® is a high-concentration hyaluronic acid bioremodeler designed to support tissue hydration through the gradual release of HA. NUCLEOFILL™, by contrast, uses polynucleotides to support fibroblast activity and tissue regeneration. Clinical evidence suggests that polynucleotide products and HA-based skin boosters may produce comparable improvements in periocular skin quality despite their different mechanisms. This supports their use as complementary options within a multimodal treatment plan rather than as direct substitutes.[2]

vs PLINEST® and REJURAN®

NUCLEOFILL™, PLINEST®, and REJURAN® all belong to the polynucleotide skin-booster class. NUCLEOFILL™ differentiates through its graded concentration range and the addition of a dedicated Hair formulation, which neither PLINEST® nor REJURAN® offers as a named product variant.

About NUCLEOFILL™

NUCLEOFILL™ is manufactured by Promoitalia Group, an Italian medical aesthetics company with an established presence in the European injectable market. The portfolio includes highly purified, high-viscosity polymerized polynucleotide gels within the PN/PDRN category, with formulations developed in different concentrations and for specific treatment areas. NUCLEOFILL™ belongs to the growing polynucleotide skin-booster segment, which has gained wider use across European and Asian aesthetic practice as interest in regenerative and biostimulatory skin-quality treatments continues to expand.[3][4]

NUCLEOFILL™ Regulatory Status

NUCLEOFILL™ is CE-marked as a Class III medical device and is available in Europe and other international markets that recognize CE certification. It is not FDA-approved for injectable use in the United States. Before purchasing or administering the product, licensed professionals should verify its regulatory status and follow any national or local requirements that apply in their jurisdiction.[3][4]

FAQs

What is NUCLEOFILL™ and how does it work?

NUCLEOFILL™ is a polymerized polynucleotide gel that supports fibroblast activity and collagen synthesis to improve skin quality — not a volumizing filler and not primarily a hydrating agent. [1]

What is the difference between NUCLEOFILL™ and PROFHILO®?

NUCLEOFILL™ uses polynucleotides to support fibroblast activity and tissue regeneration, while PROFHILO® relies on a high concentration of hyaluronic acid to improve hydration and promote tissue remodeling. Both are used to improve skin quality, but they work through different mechanisms and may be incorporated as complementary options within a broader treatment plan.[2]

Which NUCLEOFILL™ product should I choose?

Select by concentration and area: Soft Plus (15mg/2mL, 0.75%) for delicate or superficial areas; Medium (30mg/1.5mL, 2%) for general facial bio-remodeling; Medium Plus (40mg/2mL, 2%) for wider facial, body, or scalp coverage at the same concentration; Strong (37.5mg/1.5mL, 2.5%) for pronounced laxity or intensive treatment; Hair for dedicated scalp and hair-quality protocols.

How long do NUCLEOFILL™ results last?

Available clinical literature suggests that improvements may remain visible for up to 12 months in some patients. Duration varies according to the formulation, treatment area, protocol, and individual response, and maintenance sessions may be considered based on clinical assessment.

Is NUCLEOFILL™ suitable for patients with a fish allergy?

NUCLEOFILL™ polynucleotides are derived from purified salmon DNA. Fish-allergy screening should be part of pre-treatment assessment; follow the product instructions for use. [3]

Is NUCLEOFILL™ FDA approved?

No. NUCLEOFILL™ is CE-marked for European and international markets but is not currently FDA-approved for injection in the United States.

Where can licensed professionals buy NUCLEOFILL™ online?

Order the full NUCLEOFILL™ range at wholesale prices at Med Supply Solutions, with fast shipping, free shipping on orders over $500, and no minimum order.

Citations

[1] Cavallini M, Bartoletti E, Maioli L, et al. Consensus report on the use of PN-HPT™ (polynucleotides highly purified technology) in aesthetic medicine. J Cosmet Dermatol. 2021;20(3):922–928. https://pmc.ncbi.nlm.nih.gov/articles/PMC7984045/ [2] Lee YJ, Kim HT, Lee YJ, et al. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial. J Dermatolog Treat. 2022;33(1):254-260. doi:10.1080/09546634.2020.1748857 [3] Promoitalia Medical Aesthetics. NUCLEOFILL™ product range. https://webpromoitalia.com/nucleofill-range/ [4] Titcomb L. A literature review on polynucleotide efficacy on skin rejuvenation, and review of the regulatory status and guidelines around polynucleotides. J Aesthet Nurs. 2025. https://www.magonlinelibrary.com/doi/abs/10.12968/joan.2025.0009 For licensed healthcare professionals only. The content of this page is provided for informational purposes and does not constitute medical advice.