FILLMED®

Why Aesthetic Practitioners Choose FILLMED®?

FILLMED®'s primary clinical differentiator is NCTF (New Cellular Treatment Factor), the brand's flagship injectable revitalization solution. NCTF 135 HA is a mesotherapy formulation containing 59 active ingredients, including vitamins, minerals, coenzymes, amino acids, and nucleic acids, combined with non-crosslinked hyaluronic acid at a concentration of 5 mg/ml. Delivered via micro-injections, NCTF targets fibroblast activity at the cellular level to improve skin quality, hydration, and elasticity. This mechanism distinguishes FILLMED from volumizing HA fillers, in which the clinical goal is structural correction or projection. A randomized controlled trial evaluating NCTF 135 HA at 75 and 120 days reported significant improvement in superficial wrinkles and skin radiance. [1][2] The second differentiator is protocol breadth. FILLMED® covers all three stages of an aesthetic treatment sequence: skin preparation and renewal via Skin Perfusion peels and serums, injectable correction via Art Filler HA fillers, and skin quality maintenance via NCTF boosters and Skin Perfusion homecare. Practitioners building a multi-step treatment protocol can source all three stages from a single brand, without coordinating products from separate suppliers. Order FILLMED® at wholesale prices at Med Supply Solutions, or browse FILLMED® products for clinic-level treatment planning.

Shop FILLMED® at Wholesale Prices

Med Supply Solutions offers the full FILLMED® range to licensed medical professionals at wholesale prices, with fast shipping, verifiable LOT numbers, and product documentation support. Order FILLMED® online today or register for a wholesale account to browse the complete Art Filler, NCTF, and Skin Perfusion range.

What Is FILLMED® Used For?

FILLMED® supports three distinct clinical applications within a single brand. The Art Filler range uses HA fillers with lidocaine for wrinkle correction, lip augmentation, facial contour refinement, and volume restoration, with product viscosity matched to the depth of the indication. NCTF mesotherapy is used for skin revitalization, hydration improvement, and elasticity enhancement through a non-volumizing biostimulatory approach; skin quality is the clinical goal, not structural correction. Skin Perfusion supports skin renewal and post-procedure maintenance through professional-grade chemical peels, serums, and clinic-directed home care. NCTF is the most clinically distinctive element of the brand. NCTF 135 HA contains a 59-ingredient revitalizing complex with non-crosslinked HA, designed for mesotherapy delivery to target cellular skin quality rather than volume or contour. [2]

FILLMED® Product Range

The FILLMED® range is structured around three main product families. The FILLMED® Art Filler range includes HA and lidocaine fillers in various viscosities for specific indications: Art Filler Fine Lines for superficial wrinkles; Art Filler Lips for lip shape and volume; Art Filler Universal for moderate wrinkle correction and contouring; and Art Filler Volumizer for facial volume restoration. [4][6] The NCTF mesotherapy range includes NCTF 135 and FILLMED® NCTF 135 HA. Both formulations contain non-crosslinked hyaluronic acid combined with the 59-ingredient revitalizing cocktail; the distinction is HA concentration. NCTF 135 contains 2.5 mg/ml HA and is suited for younger skin, while NCTF 135 HA contains 5 mg/ml HA for more mature skin requiring greater hydration support. [2] Skin Perfusion completes the range with professional skincare products, including chemical peels with TCA, glycolic, lactic, and mandelic acids, as well as serums for in-clinic skin renewal and post-treatment maintenance.

FILLMED® Treatment Areas

Art Filler is indicated for fine perioral lines, lip augmentation and definition, nasolabial folds, cheeks and malar region, temples, midface volume loss, and overall facial contouring. Product selection is guided by tissue depth, the degree of correction required, and the practitioner's technique. NCTF mesotherapy addresses skin quality across a broader range of anatomical zones: full-face revitalization, neck and décolletage, dorsal hands, and scalp. In scalp applications, NCTF has been documented in hair mesotherapy protocols to improve hair quality. Clinics evaluating mesotherapy products as part of a broader skin revitalization service line will find the NCTF range particularly relevant.

About FILLMED®

FILLMED® is the professional medical-aesthetic division of Laboratoires Filorga, founded in 1978 in Paris, France by Dr. Michel Tordjman, a physician specializing in aesthetic medicine and cellular biology. Dr. Michel Pistor, the historical pioneer of mesotherapy as a clinical method, is a separate figure whose foundational work influenced the brand's approach to injectable revitalization. In 2015, the Filorga group separated its medical and consumer cosmetics businesses into distinct entities. In 2019, Colgate-Palmolive acquired the consumer skincare business, Laboratoires Filorga Cosmétiques, for approximately €1.5 billion. FILLMED®, the medical aesthetic division, remained independent and is backed by HLD, an entrepreneurial investment group. [5] NCTF was developed in 1981, making it one of the earliest formalized mesotherapy cocktails in aesthetic practice. FILLMED® is now available in more than 100 countries and is positioned as the original mesotherapy brand with a multimodal aesthetic platform. The name reflects this evolution: "Fill" references the injectable and filler dimension, while "Med" positions it within the medical aesthetic market — distinct from the consumer Filorga brand. The platform has grown from its mesotherapy origins to encompass the Art Filler HA range and the Skin Perfusion professional skincare line.

FILLMED® Safety Profile

Safety considerations vary by product category. Art Filler HA fillers may cause common injection-site reactions, including redness, swelling, bruising, tenderness, itching, or temporary discomfort, which typically resolve within several days. Because Art Filler products are HA-based, hyaluronidase correction may be considered when clinically appropriate. NCTF 135 HA mesotherapy may cause local redness, mild edema, small hematomas, minimal bleeding, or temporary injection-site pain, typically resolving within 24–48 hours. Skin Perfusion peels may cause temporary irritation, peeling, dryness, or sensitivity, which can be managed with appropriate post-peel skincare. General contraindications apply across the range: hypersensitivity to any component, active skin infection or inflammation, pregnancy or breastfeeding, and use in patients under 18, where safety has not been established. For NCTF specifically, practitioners should assess potential sensitivity to the multi-component formulation given the 59-ingredient composition.

FILLMED® vs Competition

Compared with JUVÉDERM®, FILLMED® offers a broader clinical scope. JUVÉDERM® is an HA filler range built on the VYCROSS® crosslinking platform for facial correction and volume. [3] FILLMED® combines HA fillers with NCTF mesotherapy and Skin Perfusion skincare — a practitioner stocking FILLMED® gains access to three product categories from a single brand. For clinics building a complete treatment protocol rather than a filler-focused service line, the breadth is a meaningful operational and clinical difference. Compared with TEOSYAL®, which is primarily known for its PURESENSE and RHA filler lines, FILLMED® offers a broader range of skin-quality components through NCTF. Teosyal has no direct equivalent to NCTF in its range. For practices where mesotherapy forms part of the core service offering, FILLMED® is a more complete aesthetic platform. Profhilo is the closest competitor to FILLMED® NCTF, as both are injectable, skin-quality treatments that use HA. The key difference is mechanism: Profhilo delivers a high-concentration biphasic HA formulation via five standardized injection points, while NCTF combines non-crosslinked HA with a 59-ingredient revitalizing cocktail through mesotherapy micro-injection. The clinical objectives partially overlap — hydration and skin quality — but the formulation rationale and delivery protocols are distinct.

FILLMED® Regulatory Status

FILLMED® Art Filler products are Class III CE-marked medical devices, compliant with the EU Medical Device Regulation (MDR), and available across the EU and in more than 100 countries internationally. [6] NCTF 135 HA is also CE-marked as a medical device for professional aesthetic mesotherapy. Product registration, approved indications, labeling, and distribution pathways vary by jurisdiction. FILLMED® Art Filler and NCTF products are not FDA-approved for use in the United States. The brand is primarily distributed across the EU, the Middle East, Asia, and Latin American markets. Practitioners should verify local regulatory status, product documentation, and authorized distribution channels before ordering or using FILLMED® products.

FAQs

1. What is FILLMED® NCTF and how does it work?

FILLMED® NCTF is a professional mesotherapy solution designed to support skin revitalization rather than volume correction. NCTF 135 HA combines 59 active ingredients — including vitamins, minerals, coenzymes, amino acids, and nucleic acids — with non-crosslinked HA at 5 mg/ml, delivered through micro-injections to stimulate fibroblast activity and improve skin hydration, elasticity, and overall quality. [1][2]

2. What is the difference between NCTF 135 and NCTF 135 HA?

Both NCTF 135 and NCTF 135 HA contain non-crosslinked hyaluronic acid combined with the 59-ingredient revitalizing cocktail. The distinction is the HA concentration: NCTF 135 contains 2.5 mg/ml HA and is suited for younger skin, while NCTF 135 HA contains 5 mg/ml HA and is suited for more mature skin requiring greater hydration support. [2]

3. What is the FILLMED® Art Filler range?

FILLMED® Art Filler is the brand's HA and lidocaine dermal filler range, available in multiple viscosities for specific indications. Products include Art Filler Fine Lines for superficial wrinkles, Art Filler Lips for lip shape and volume, Art Filler Universal for broader correction and contouring, and Art Filler Volumizer for facial volume restoration. [3]

4. Is FILLMED® FDA approved?

No. FILLMED® Art Filler and NCTF products are CE-marked medical devices primarily distributed outside the US market. They are not FDA-approved for use in the United States. Practitioners should confirm local regulatory status before ordering.

5. Can FILLMED® NCTF be reversed?

NCTF 135 and NCTF 135 HA both contain non-crosslinked HA — not a crosslinked volumizing gel — and are not used in the same clinical context as structural fillers. They are not typically discussed within the same reversal framework as crosslinked HA fillers. If an adverse reaction occurs, management should be guided by the product used, injection technique, and clinical presentation.

6. How does FILLMED® compare to Profhilo?

Both FILLMED® NCTF and Profhilo target injectable skin-quality improvement, with HA as a core component. Profhilo uses a high-concentration biphasic HA approach delivered via standardized injection points, while NCTF combines non-crosslinked HA with a 59-ingredient mesotherapy cocktail. It has a different formulation, rationale, mechanism, and delivery protocol.

7. Where can licensed professionals order FILLMED® products?

Licensed professionals can order the full FILLMED® range at wholesale prices at Med Supply Solutions. Register for an account or contact the team for current availability, documentation, and product support.

Citations

1. Fanian F, Deutsch JJ, Bousquet MT, et al. A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study. J Dermatolog Treat. 2023;34(1):2216323. doi:1080/09546634.2023.2216323
2. Clinical evaluation of anti-aging efficacy of mesotherapy with NCTF® 135 HA on healthy volunteers. 2014. Available at: https://fillmed.com/wp-content/uploads/2025/12/NCTF-135-HA.pdf
3. Braccini F, Fanian F, Garcia P, et al. Comparative clinical study for the efficacy and safety of two different hyaluronic acid-based fillers with Tri-Hyal versus Vycross technology: A long-term prospective randomized clinical trial. J Cosmet Dermatol. 2023;22(2):473-485. doi:1111/jocd.15200
4. Prikhnenko S. Polycomponent mesotherapy formulations for the treatment of skin aging and improvement of skin quality. Clin Cosmet Investig Dermatol. 2015;8:151-157. Published 2015 Apr 7. doi:10.2147/CCID.S76721
5. Autorité de la concurrence. Colgate-Palmolive / Laboratoires Filorga Cosmétiques acquisition review. Available at: https://www.autoritedelaconcurrence.fr/en/print/pdf/node/6310
6. Art Filler Fine Lines MDR CE Documentation (Class III Medical Device). 2025. Available at: https://fillmed.com/wp-content/uploads/2025/10/AF-FINE-LINES-MDR-1025.pdf

For licensed healthcare professionals only. The content of this page is provided for informational purposes and does not constitute medical advice.