info@medsupplysolutions.com 1-844-226-8277
Wholesale prices
5% On your first order
No Minimum orders
Delivery Guaranteed

PLINEST®

PLINEST® is a sterile, non-pyrogenic, viscoelastic gel based on highly purified long-chain polynucleotides (PN-HPT™). It is developed by Mastelli Srl, a pharmaceutical company known for its advancements in regenerative and aesthetic medicine. PLINEST® is designed to improve skin quality, elasticity, and hydration through bio-revitalization and dermal priming.

PLINEST®
5 items
Sort by
PLINEST® EYE by Mastelli is a box labeled with "Polinucleotidi" and "Polynucleotides." The packaging is mainly white and mint green, showcasing the Mastelli Aesthetics logo and HPT branding.

PLINEST® EYE
$99.00
The "PLINEST® HAIR" box by Mastelli, in a pink and white design, showcases polynucleotides with "HPT Technology" mentioned on the front.

PLINEST® HAIR
$99.00
The image depicts a white box of PLINEST® ONE from Mastelli Aesthetics, featuring a yellow section at the bottom right. The front highlights "Polinucleotidi" and "HPT Technology.

PLINEST® ONE
$79.00
Image of a PLINEST® FAST (2ml) product box featuring a predominantly white design with yellow accents at the bottom. The text includes "Plinest Fast," "Polinucleotidi Polynucleotides," "HPT Technology," and the brand name "Mastelli.

PLINEST® FAST (2ml)

POLYNUCLEOTIDES HPT

$109.00
PLINEST® box with a yellow and white design, featuring the words "Polinucleotidi," "Polynucleotides," and "HPT Technology," along with the "Mastelli" logo at the bottom.

PLINEST®

POLYNUCLEOTIDES HPT

$79.00

Most ordered from PLINEST®

Image of a PLINEST® FAST (2ml) product box featuring a predominantly white design with yellow accents at the bottom. The text includes "Plinest Fast," "Polinucleotidi Polynucleotides," "HPT Technology," and the brand name "Mastelli.

PLINEST® FAST (2ml)

POLYNUCLEOTIDES HPT

$109.00
PLINEST® EYE by Mastelli is a box labeled with "Polinucleotidi" and "Polynucleotides." The packaging is mainly white and mint green, showcasing the Mastelli Aesthetics logo and HPT branding.

PLINEST® EYE
$99.00
The "PLINEST® HAIR" box by Mastelli, in a pink and white design, showcases polynucleotides with "HPT Technology" mentioned on the front.

PLINEST® HAIR
$99.00
The image depicts a white box of PLINEST® ONE from Mastelli Aesthetics, featuring a yellow section at the bottom right. The front highlights "Polinucleotidi" and "HPT Technology.

PLINEST® ONE
$79.00

Global Best Sellers

ORTHOVISC 2ML ENGLISH 01

ORTHOVISC®

Sodum Hyaluronate

$52.00
JUVEDERM VOLUMA LIDOCAINE 2X1ML 01

JUVÉDERM® VOLUMA® with Lidocaine

Hyaluronic acid

$359.00
A blue rectangular box labeled "RESTYLANE® LYFT with Lidocaine" containing 1mL injectable gel by Galderma, displayed against a plain white background.

RESTYLANE® LYFT with Lidocaine

Hyaluronic acid

$189.00
A blue and purple box of RESTYLANE® KYSSE with Lidocaine features a shiny security sticker in the top right corner.

RESTYLANE® KYSSE with Lidocaine

Hyaluronic acid

$189.00

PLINEST® Product Range

The PLINEST® line includes formulations using PN-HPT™ (Polynucleotides Highly Purified Technology), tailored for skin bio-regeneration and acne scar treatment. Each formulation is packaged for professional medical use.
  • PLINEST®: General bio-revitalization and anti-aging
  • PLINEST® for Acne Scars: Higher volume protocol specifically for fibrous areas like acne scars
  • Pack size: 1 x 2 mL pre-filled syringe
  • Needles included: 2 x 30G ½ needles

Key Benefits of PLINEST®

PLINEST® offers visible improvements in skin texture, elasticity, and hydration, with a strong safety profile and minimal discomfort during administration. It can be used as a standalone treatment or as a priming agent before other aesthetic procedures.
  • +14.7% increase in skin hydration after treatment
  • +21.8% improvement in skin elasticity
  • 91% of patients showed clinical improvement in fine wrinkle reduction
  • 16.7% decrease in skin roughness (≤ 2.5 mm)
  • Very well tolerated; no severe side effects reported
  • Synergistic use with fillers, lasers, radiofrequency, and peels

Clinical Indications for PLINEST®

PLINEST® is indicated for adult patients seeking treatment for skin aging, laxity, and texture irregularities. It is particularly effective in areas prone to volume loss or fibrous scarring.
  • Treatment areas:
    • Face (n=132 patients)
    • Neck (n=55 patients)
    • Décolleté (n=14 patients)
  • Patient profiles: Suitable for both younger individuals (for prevention) and mature skin
  • Acne scars: Effective in remodeling fibrous tissue
Check out Plinest Before and After Results here.

PLINEST® Ingredients

PLINEST® is composed exclusively of high-purity polynucleotides, without hyaluronic acid or lidocaine. Its natural, DNA-based composition ensures biocompatibility and low immunogenicity.
  • Active ingredient: PN-HPT™, 40 mg/2 mL
  • Composition: Long-chain deoxyribonucleotide polymers (DNA fractions)
  • Form: Sterile, viscoelastic gel
  • Free from: Lidocaine, crosslinked HA, or chemical additives

PLINEST® Administration Technique

PLINEST® is injected intradermally using either micro-droplet or linear retrograde techniques. Treatment is administered by trained professionals based on the clinical indication.
  • Depth of injection: Intradermal
  • Technique options:
    • 30 micro-droplets (0.1–0.2 mL per point)
    • Linear retrograde technique
  • Volume per session:
    • 2 mL every 14–21 days, total 3 sessions (anti-aging)
    • 4 mL every 3 weeks, total 2 sessions (acne scars)
  • Needle: 30G ½

PLINEST® Storage Conditions

Proper storage ensures product integrity and clinical safety. PLINEST® should be kept in controlled conditions as specified below.
  • Temperature: Store between 2°C and 25°C
  • Handling: Do not freeze; protect from direct light
  • Shelf life: Follow expiry date on the packaging

PLINEST® Side Effects

PLINEST® demonstrates a high safety profile with no severe adverse events reported in the study cohort. Reactions were minor and transient due to the biocompatible nature of PN-HPT™.
  • Common effects:
    • Mild injection site discomfort
    • Temporary redness or swelling
  • Severe reactions: None reported in clinical studies
  • Contraindications: Not explicitly listed; assume standard dermal filler precautions (e.g., hypersensitivity to any components)

FAQs About PLINEST®

What is PN-HPT™ in PLINEST®? PN-HPT™ stands for Polynucleotides Highly Purified Technology, a DNA-derived bioactive substance that promotes skin regeneration. How many sessions are needed? Protocols typically involve 3 sessions every 2–3 weeks, with maintenance every 1–3 months. Can PLINEST® be combined with other treatments? Yes, it enhances outcomes when used alongside fillers, lasers, peels, and microneedling. Is PLINEST® suitable for young patients? Yes, PLINEST® can be used preventively to maintain skin quality in younger individuals.

Buy PLINEST® Online

Licensed medical professionals can purchase PLINEST® directly Med Supply Solutions.. Browse the full selection of PLINEST® formulations in our shop to offer your patients clinically proven skin bio-regeneration with PN-HPT™ technology.
Newsletter

Subscribe for exclusive offers and updates on new arrivals