Plinest Before and After – With a Photo Gallery

Last Updated On: June 16, 2025

Intradermal treatment with the PN-HPT®–based medical device led to meaningful improvement in skin surface, firmness, pigmentation, and radiance with complete safety. According to clinical findings, these aesthetic benefits were maintained through the six-month follow-up in all participants, showing both short-term and sustained results.

These outcomes have fueled interest in regenerative treatments that go beyond surface-level fixes. Plinest, made with highly purified polynucleotides, has gained attention for its ability to support cellular renewal and improve overall skin quality. Users and professionals alike report visible improvements in texture, tone, and even scarring.

In this article, we’ll explore Plinest’s results before and after treatment, share a curated photo gallery, and walk you through what to expect in terms of benefits, sessions, and long-term outcomes.

Key Takeaways

• Plinest is a regenerative, polynucleotide-based injectable that activates fibroblasts, stimulates collagen and elastin production, and supports deep skin repair over time.
• Visible improvements typically begin within the first 1–2 weeks, including better hydration and a glow, with significant changes, such as firmer skin and softened fine lines, emerging by weeks 3–4 and continuing through months 2–3.
• A complete treatment cycle consists of 3–5 sessions spaced 3–4 weeks apart, with maintenance sessions recommended every 6 months to sustain results.
• Treatment is customizable for the face, under-eye area, neck, hands, and scars, with dosages tailored to each individual’s skin type and specific concerns.
• Before-and-after photos show meaningful, progressive enhancements in tone, texture, and elasticity—without adding volume or causing drastic changes.
• Proper documentation and photo comparisons (consistent lighting, angles, no makeup) are key for tracking outcomes and patient education.
• Plinest is suitable for sensitive skin and can be safely combined with other aesthetic treatments like microneedling or Botox for synergistic benefits.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to buy Plinest Fillers online, contact our sales department for more information.  

PLINEST® EYE

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POLYNUCLEOTIDES HPT

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What to Expect After Treatment: Timeline and Improvements

Plinest is a polynucleotide-based injectable designed to activate fibroblasts, boost collagen synthesis, and repair skin tissue. Most patients begin to notice visible improvements within the first few weeks after treatment, with results continuing to build progressively over time. Here’s a general Plinest recovery and results timeline:

• Days 1–3: You may experience mild swelling, slight bruising, or redness at the injection sites, which is a normal reaction to the treatment. These symptoms are typically short-lived and resolve on their own without the need for medication. Most patients can resume normal activities within a day, with only minimal downtime required.
• Week 1–2: Subtle improvements begin to surface, such as increased hydration, a plumper skin feel, and a healthier-looking glow. Skin may appear fresher and smoother to the touch, although more profound structural changes are still developing underneath. These early results signal the beginning of Plinest’s biostimulatory effects, helping the skin look more rejuvenated.
• Weeks 3–4: Collagen and elastin production begin ramping up. You’ll notice firmer skin, improved elasticity, and softening of fine lines, especially around the eyes and mouth. Skin tone may become more even, and texture begins to refine, giving you a rejuvenated, well-rested appearance.
• Months 2–3: Regeneration progresses into the deeper layers of the skin. Acne scars may start to flatten, dull or sun-damaged skin becomes more luminous, and sagging areas appear more lifted. Improvements are more defined and visible by this point, with enhanced skin density and a youthful, supple look.

After three sessions, full, cumulative results become evident. Most patients see significantly firmer and smoother skin, reduced pore size, fewer fine lines, and a naturally radiant complexion. The skin appears healthier overall, and the treatment’s regenerative effects continue working even beyond the last session.

Photo Gallery: Facial Rejuvenation and Scar Repair

Visual transformation plays a crucial role in evaluating the effectiveness of biorevitalization treatments, such as Plinest. Whether you’re targeting early signs of aging or acne-related scarring, photographic comparisons offer valuable insight into what’s realistically achievable. Below, you’ll find a curated gallery of Plinest before and after results, highlighting improvements in skin tone, elasticity, and texture across a range of facial concerns.

Image Courtesy of Infinity Clinic

Before Plinest, facial skin can appear tired, dull, and exhibit signs of early aging, including fine lines, uneven texture, and sagging. After treatment, the complexion appears more radiant and even-toned, with firmer, hydrated skin and improved elasticity. Overall, the facial contours appear subtly lifted, delivering a youthful and revitalized glow without added volume.

Image Courtesy of Clarendon Aesthetics

After completing a full course of Plinest, the under-eye area, which may have appeared hollow with visible dark circles, fine lines, and a crepey texture, shows a noticeable reduction in pigmentation and puffiness. Skin thickness improves, and the under-eye contour becomes smoother, brighter, and more refreshed.

As these images reveal, Plinest delivers gradual yet meaningful changes that enhance skin health from within. From fading acne scars to restoring youthful radiance, the results speak for themselves. Patients can also compare other similar treatments, such as Plinest vs Rejuran. They can consider these outcomes and consult a professional to determine the best treatment for your skin’s specific needs.

Treatment Areas and Dosing Considerations

Plinest is a highly adaptable biorevitalization treatment used across multiple facial and body zones. Its versatility allows for targeted skin repair, collagen stimulation, and hydration, depending on the area of concern. The dosing varies by individual skin condition, age, and treatment goal. Below is a table summarizing the most common treatment areas and typical dosage guidelines:

Tips for Documenting and Presenting Clinical Outcomes

Whether you’re a patient or a skincare professional, documenting Plinest results before and after is key to measuring visible improvements and adjusting treatment plans as needed. For accurate photo comparisons, maintain consistent lighting—natural daylight or a ring light works best. Take photos from the same angle and distance each time, and capture various angles (front, sides, 45-degree) to reflect facial contours and skin changes more clearly.

For practitioners, obtaining patient consent before sharing before-and-after visuals is essential. Include clear photo captions with treatment dates, number of sessions, and areas treated to set proper expectations. Keep hair pulled back and avoid makeup or filters to highlight authentic outcomes. Consistent documentation builds trust and reinforces treatment credibility, especially when educating new clients about results over time.

Conclusion

The transformative effects of Plinest are best appreciated over time. From firmer texture and hydrated glow to reduced scars and smoother skin tone, the Plinest before and after difference is tangible and measurable. Plinest is ideal for individuals looking to restore skin from within without drastic changes or invasive procedures. 

By following a structured treatment plan and documenting progress, patients can enjoy long-term, natural-looking results.

FAQs

1. How long do Plinest results last?

Results can last 6 to 9 months after completing the entire course, depending on skin condition and lifestyle. Maintenance sessions, conducted every 4–6 months, help prolong the effects of the treatment.

2. Is Plinest safe for sensitive skin?

Yes, Plinest uses highly purified polynucleotides, making it biocompatible and generally safe for sensitive skin when administered correctly.

3. Can I combine Plinest with other treatments?

Yes. It’s often combined with laser, microneedling, or Botox treatments for enhanced results. Your provider will create a customized schedule to avoid overstimulation.

4. How soon can I see results after my first session?

Most patients notice subtle changes in hydration and smoothness within 7–10 days, with more dramatic results appearing after 2–3 sessions.

References

Lim TS, Liew S, Tee XJ, et al. Polynucleotides HPT for Asian skin regeneration and rejuvenation. Clinical Cosmetic and Investigational Dermatology. 2024;Volume 17:417-431. doi:10.2147/ccid.s437942

Cavallini M, Bartoletti E, Maioli L, et al. Consensus report on the use of PN-HPT™ (polynucleotides highly purified technology) in aesthetic medicine. J Cosmet Dermatol. 2021;20(3):922-928. doi:10.1111/jocd.13679