Jaydess Side Effects – The Complete List

Last Updated On: June 4, 2025

Although the levonorgestrel 52 mg intrauterine device (IUD) is designed for localized hormone release, some users still report hormone-related side effects. In a study involving 1,714 women, side effects like acne and changes in libido were more common among those who had recently used combined hormonal contraception. While most symptoms were mild and rarely led to discontinuation, the findings underscore the importance of understanding how previous contraceptive use may influence IUD-related side effects.

Hormonal options such as Jaydess come with a distinct set of side effects, shaped by their unique formulation and hormone delivery. Recognizing these differences can empower users to make more informed and personalized choices about birth control.

In this article, we’ll unpack the complete list of Jaydess side effects, helping you better understand its potential benefits and drawbacks before deciding if it’s the right fit for your lifestyle and body.

Key Takeaways

• Jaydess is a hormonal IUD that provides up to three years of pregnancy prevention, making it a convenient long-term birth control option.
• The most common side effects include irregular bleeding, pelvic cramping, breast tenderness, headaches, and nausea, especially in the first few months of use.
• Over time, many users experience lighter periods or even amenorrhea as the body adjusts to the IUD’s hormone release.
• Rare but serious complications such as device expulsion, uterine perforation, pelvic inflammatory disease (PID), and ovarian cysts can occur and require prompt medical attention.
• Hormonal side effects like mood changes, acne, decreased libido, and minor weight fluctuations may occur due to systemic absorption of levonorgestrel.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to buy Jaydess online, contact our sales department for more information. 

Most Common Jaydess Side Effects Reported in Clinical Practice

The majority of Jaydess side effects are generally mild and result from either the localized release of levonorgestrel or the physical presence of the IUD in the uterus. These reactions are part of the body’s natural adjustment phase and often signal that the device is beginning to work. For most users, these symptoms gradually subside within a few weeks to several months as the body adapts to the IUD’s hormonal effects and structural presence.

Typical Physical and Menstrual Side Effects

• Irregular Bleeding: One of the most frequently reported issues in the first 3 to 6 months of Jaydess use. Spotting, extended periods, or disrupted menstrual cycles are common as the uterus adjusts to the hormonal thinning of the endometrium. While initially frustrating, these changes typically stabilize over time.
• Lighter Periods or Amenorrhea: As the uterine lining becomes thinner due to levonorgestrel, many users notice lighter flows or even the absence of periods (amenorrhea). This effect can take several cycles to develop and is often viewed as a benefit rather than a drawback.
• Pelvic Discomfort or Cramps: Cramping often occurs during and shortly after insertion but may also reappear during monthly cycles. These cramps are typically mild to moderate and can be managed with over-the-counter pain relief, hydration, and rest.
• Headache or Nausea: Some users report transient headaches or nausea, especially during the first week of use. These symptoms are typically associated with initial hormonal changes and often resolve on their own without the need for medical intervention.
• Breast Tenderness: Increased breast swelling, tenderness, or sensitivity may occur in the first few months. Supportive bras and reducing caffeine and sodium intake may help alleviate discomfort.

Serious and Less Common Jaydess Side Effects to Monitor

While the Jaydess IUD is considered safe for most users, it’s important to be aware of rare but potentially serious complications. These events are uncommon but require prompt medical attention if symptoms arise.

• Device Expulsion: The IUD may be partially or fully expelled from the uterus, often in the first year of use. Symptoms include pelvic cramping, unusual discharge, or a change in bleeding patterns. If the strings are no longer detectable, medical evaluation is needed. Expulsion decreases contraceptive protection and may necessitate reinsertion.
• Perforation: This rare complication occurs when the IUD punctures the uterine wall, usually during insertion. While it may go unnoticed at first, signs include sharp abdominal pain, heavy bleeding, or a missing IUD string. In severe cases, surgical retrieval may be required.
• Pelvic Inflammatory Disease (PID): Though rare with Jaydess, PID can still occur, particularly if an existing sexually transmitted infection is present. Symptoms include fever, pelvic pain, pain during sex, and abnormal discharge. Early diagnosis and treatment are crucial to prevent complications such as infertility.
• Ovarian Cysts: Functional ovarian cysts may form due to hormonal disruption of ovulation. These cysts are usually benign and resolve on their own, but can cause bloating, pelvic pain, or cycle irregularity. Persistent or painful cysts may warrant further assessment.

If you notice severe pain, heavy bleeding, fever, or any sudden changes, seek medical attention right away. Early action can prevent complications and ensure safe and continued use of Jaydess.

Hormonal Jaydess Side Effects and Systemic Impact

Although Jaydess delivers a small, localized dose of levonorgestrel, some of the hormone may enter the bloodstream, causing mild systemic effects in some users. These are less common but worth noting, particularly for individuals with known hormonal sensitivities.

• Mood Changes: Feelings of irritability, anxiety, or depression may arise. While studies yield mixed results, users should take these signs seriously and consult a healthcare provider.
• Decreased Libido: Some women report a lower sex drive, likely due to hormonal shifts. Open communication with your partner and healthcare provider can help address this concern.
• Acne and Skin Changes: Breakouts or oily skin may appear, especially during the first few months. These effects tend to subside as hormone levels return to normal.
• Weight Changes: A small number of users experience mild weight gain or fluid retention, although this is not universal and is often not sustained in the long term.

If you plan to undergo imaging procedures such as an MRI, be sure to review the Jaydess IUD MRI safety guidelines with your provider. Most modern IUDs are MRI-compatible; however, proper documentation and communication are essential to ensure accurate diagnostics and safe imaging conditions.

Timeline of Jaydess Side Effects: Onset and Duration

Understanding the typical side effect timeline can help ease anxiety and prepare users for the phases of adjustment. Side effects generally follow a predictable pattern:

Each individual responds differently, and while many users adjust with minimal discomfort, regular follow-ups and open dialogue with a healthcare provider are essential for managing long-term use comfortably.

Conclusion

Jaydess is a low-maintenance, hormonal IUD that provides up to three years of pregnancy prevention, making it an attractive option for many. While most side effects are temporary and manageable, being informed about what to expect empowers users to make confident decisions.

Discuss your medical history, lifestyle, and preferences with a healthcare provider to determine if Jaydess is the right fit for you. If you’re already using it, staying alert to changes in your body and knowing when to seek medical advice ensures the safest and most effective contraceptive experience.

FAQs

1. How long do Jaydess side effects last?

Most side effects, such as cramping, spotting, or breast tenderness, typically resolve within the first 3 to 6 months. Your doctor should evaluate persistent or severe symptoms.

2. Can Jaydess cause weight gain?

While some users report slight weight gain or fluid retention, clinical studies have not confirmed a direct link between these symptoms and the use of this product. Lifestyle factors may also play a role.

3. Is it normal to stop having periods on Jaydess?

Yes. Lighter or absent periods are a common side effect. Many users find this a benefit rather than a concern.

4. Should I worry about MRIs if I have Jaydess?

Jaydess is classified as MR Conditional. This means it can safely be used in an MRI under specific conditions. 

References

Kerns JL, Keder LM, Cwiak CA, et al. Hormone-related side effects in new users of a levonorgestrel 52-mg intrauterine device. Am J Obstet Gynecol. 2024;231(6):628.e1.

Martell S, Marini C, Kondas CA, Deutch AB. Psychological side effects of hormonal contraception: a disconnect between patients and providers. Contracept Reprod Med. 2023;8(1):9.