DYSPORT® 300u (English Alternative)

DYSPORT® is known for its fast onset, long duration of action, and diffuse spread, which can benefit treatment of larger or more dynamic muscle groups.

• 300 Units of botulinum toxin type A per vial

• Fast onset: 2–3 days for many indications

• Duration: Effects last 12 to 16 weeks

• Wider diffusion compared to other toxins, ideal for larger muscle areas

• Indicated for aesthetic and therapeutic use

• Supplied as a freeze-dried powder for reconstitution

DYSPORT® is indicated for both aesthetic correction of facial wrinkles and therapeutic management of neuromuscular disorders. It is approved for use in adults and pediatric patients, depending on the indication.

Aesthetic Indication:

• Moderate to severe glabellar lines in adults under 65

Therapeutic Indications:

• Cervical dystonia in adults

• Upper and lower limb spasticity in adults

• Pediatric lower limb spasticity (≥2 years of age)

• Blepharospasm and hemifacial spasm

• Chronic sialorrhea in adults and pediatric patients (≥2 years)

Contraindications:

• Hypersensitivity to botulinum toxin A or excipients

• Presence of infection at the injection site

• Patients with neuromuscular transmission disorders (e.g., myasthenia gravis)

Common Side Effects:

• Headache, injection site pain, eyelid drooping (ptosis)

• Dry mouth, muscle weakness, nausea

• Flu-like symptoms

Rare/Serious Effects:

• Dysphagia, dyspnea, anaphylaxis

• Diffusion-related effects: generalized muscle weakness

DYSPORT® is provided as a sterile, white lyophilized powder in a single-dose vial. It must be reconstituted with sterile 0.9% sodium chloride before use. The formulation contains human albumin and lactose as stabilizers.

Packaging:

• 300-unit vial, clearly labeled for identification

• Glass vial with rubber stopper and flip-off cap

Ingredients:

• Clostridium botulinum type A toxin-haemagglutinin complex: 300 units

• Human albumin: 125 mcg

• Lactose monohydrate: 2.5 mg

• Free of preservatives and complexing proteins

The product does not contain animal-derived ingredients, enhancing its safety for allergic or sensitive patients.

DYSPORT® must be administered by qualified healthcare professionals experienced in botulinum toxin injection. The dosage and injection pattern vary based on the indication and treatment site.

Reconstitution:

• Use sterile sodium chloride 0.9% without preservatives

• Add 1.5 mL to 2.5 mL of saline to the vial to achieve appropriate concentration

• Gently rotate the vial; do not shake vigorously

Dosage Guidelines:

• Glabellar lines: Total of 50 units, divided into 5 points (10 units each)

• Cervical dystonia: Typical dose of 500 units, adjusted based on muscle size

• Upper limb spasticity: Doses range from 500 to 1000 units

• Pediatric dosing: Based on weight (units/kg)

Administration:

• Intramuscular or intradermal injection

• Use fine-gauge needles (e.g., 30G) for facial treatments

• Rotate injection sites to minimize irritation

Storage Instructions:

• Unopened vials: Store at 2–8°C (refrigerated)

• After reconstitution: Use within 24 hours if stored at 2–8°C

• Do not freeze; protect from light