Saxenda Before and After – A Photo Gallery

Last Updated On: May 27, 2025

In a 56-week clinical trial, patients treated with Saxenda® (liraglutide) achieved remarkable weight loss, with many losing ≥5% of their baseline body weight. On average, participants shed 21 pounds, accompanied by a significant reduction in waist circumference.

As a GLP-1 receptor agonist, Saxenda works by regulating appetite and caloric intake, facilitating gradual and sustained weight loss. FDA-approved for weight management, it provides a structured approach for individuals seeking professional help in their weight loss journey.

This article showcases a photo gallery of real-life before-and-after results from individuals who have experienced the transformative effects of Saxenda. These visual testimonials provide an inspiring glimpse into the potential changes and improvements achievable with this treatment.

Key Takeaways

• Most patients experience noticeable physical and emotional changes within the first few months of Saxenda treatment.
• By 8 weeks, patients typically lose 5–7% of their initial body weight, often noticing looser clothing and increased energy.
• At 12 weeks, around 10% weight loss is a key benchmark to evaluate treatment continuation and is associated with improved self-esteem and metabolic health.
• Weight loss plateaus are normal; consistent Saxenda dosing, lifestyle changes, and regular healthcare follow-ups are essential for long-term success.
• Saxenda also improves key metabolic markers, including hemoglobin A1c, blood pressure, and lipid profiles, contributing to overall health benefits beyond weight loss.
• Patient responses vary due to genetics, metabolism, and health conditions, making realistic expectations critical for motivation.
• Combining medication with diet and exercise and adhering to the prescribed dosing schedule maximizes results.
• Open communication with healthcare providers helps manage side effects and supports a successful weight loss journey.

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Case Studies and Patient Profiles

Image Courtesy of Numan

Real stories offer a deeper glimpse into what to expect from Saxenda. Beyond clinical data, users’ lived experiences reveal the emotional and physical changes they undergo during treatment. These testimonials highlight the challenges, milestones, and triumphs, giving a clearer picture of what Saxenda can truly mean  before and after 

• One patient, now in her third week of treatment, reported losing 14 pounds. She noted minimal side effects, mainly “a light nausea when it is time to eat,” especially after dose increases. What stood out most to her was the improvement in stamina and blood pressure, allowing her to cut her medication in half. “I feel good… my sugar cravings are non-existent,” she wrote, adding that giving herself the injection was surprisingly easy.
• Another long-term user started Saxenda in April 2019 at 273 lbs and lost over 90 lbs—nearly a third of her body weight. “It is a whole different life for me,” she shared. Tasks that once felt impossible, like walking up stairs, are now part of her everyday routine. She’s even added a twice-daily dog walk into her schedule, hitting up to 10,000 steps daily. A year after stopping Saxenda, she’s maintained her weight loss.
• One more patient, a 62-year-old with a history of food addiction, began treatment in late 2020. Despite early side effects like nausea, acid reflux, and constipation, she found ways to manage them—adding All-Bran and FloraLax to her daily routine. After four months, all side effects subsided. She went from 201 lbs (BMI 34) to 165 lbs (BMI 29), and says, “Words can never explain the pure joy I feel inside.” Saxenda, she believes, helped reset her metabolism and broke the cycle of constant eating, even late at night.

These testimonials emphasize that weight loss with Saxenda is more than just numbers on a scale—it’s about reclaiming health, building confidence, and reshaping daily habits. While each journey is unique, the consistent theme is hope. Consulting with a healthcare provider is key to determining if Saxenda is the right step toward transformation.

Timeframes and Weight Loss Milestones

Tracking progress during Saxenda treatment provides valuable insights into how the body responds over time. Most patients observe both physical and emotional changes within the first few months. Below is a general overview of typical milestones when using Saxenda for weight management:

It’s important to remember that each patient’s journey is unique. Weight loss plateaus are normal and do not indicate failure. Consistent adherence to Saxenda dosing, lifestyle modifications, and regular medical follow-ups is key to sustaining momentum and achieving long-term success.

Comorbidity Improvements

Saxenda’s benefits extend beyond simple weight reduction, enhancing overall metabolic health. As body mass decreases, a cascade of health improvements often follows, reinforcing Saxenda’s role as a comprehensive obesity management tool:

• Hemoglobin A1c Levels: Clinical data demonstrate Saxenda’s ability to lower HbA1c, a vital marker of long-term blood sugar control. This effect is especially beneficial for patients with prediabetes or type 2 diabetes, potentially delaying or reducing the need for other diabetic medications.
• Blood Pressure: Weight loss coupled with improved vascular function frequently reduces both systolic and diastolic blood pressure, lowering the risk of stroke, heart attack, and other cardiovascular events.
• Lipid Profiles: Patients often experience favorable changes in lipid levels, including decreased LDL cholesterol and triglycerides, alongside possible increases in HDL cholesterol, enhancing cardiovascular protection.
• Overall Quality of Life: Beyond measurable markers, many patients report feeling more energetic, mobile, and emotionally balanced. These improvements can boost self-esteem, reduce depressive symptoms, and encourage adherence to healthier lifestyle choices.

By positively impacting multiple metabolic parameters, Saxenda offers a holistic approach to obesity management beyond simple weight loss.

Setting Realistic Patient Expectations for Saxenda Treatments

While Saxenda shows strong potential for weight loss, outcomes vary based on individual factors such as genetics, metabolism, and pre-existing health conditions. Some patients lose weight rapidly, whereas others experience slower progress. Managing expectations is crucial to maintaining motivation and avoiding discouragement due to comparisons.

Lifestyle changes are integral to Saxenda’s effectiveness. Combining the medication with a balanced diet and regular exercise significantly improves results. Equally important is strict adherence to the prescribed Saxenda dosing schedule. Skipping doses or inconsistent usage can hinder effectiveness and delay progress.

Staying informed and actively engaged throughout treatment empowers patients to take control of their health and achieve lasting results.

Conclusion

Saxenda has established itself as an effective weight management tool, delivering physical transformations and essential health benefits. Patients can maximize the medication’s advantages by understanding the treatment timeline, setting achievable goals, and maintaining open communication with healthcare providers.

Every weight loss journey is unique; sustainable success is within reach with proper support, adherence to the dosing schedule, and lifestyle modifications.

FAQs

1. How soon can I expect to see results with Saxenda?

While individual results vary, many patients notice weight loss within 4 to 8 weeks of starting treatment.

2. What is the recommended dosing schedule for Saxenda?

Saxenda dosing typically starts at 0.6 mg daily and increases by 0.6 mg weekly until the maintenance dose is 3.0 mg.

3. Are there any common side effects associated with Saxenda?

Common side effects include nausea, diarrhea, constipation, and vomiting. These often diminish as the body adjusts to the medication.

4. Can I continue using Saxenda if I don’t achieve significant weight loss?

Treatment should be re-evaluated if a patient hasn’t lost at least 5% of their initial body weight after 12 weeks on the maintenance dose. Consult with your healthcare provider for guidance.

References

Significant weight loss with Saxenda: efficacy and safety overview. Novo Nordisk website. Accessed April 25, 2025. https://www.novomedlink.com/obesity/products/treatments/saxenda/efficacy-safety/significant-weight-loss.html 

Institute of Medicine (US) Subcommittee on Military Weight Management. Weight management: state of the science and opportunities for military programs. Washington (DC): National Academies Press (US); 2004. Chapter 4, Weight-loss and maintenance strategies. Available from: https://www.ncbi.nlm.nih.gov/books/NBK221839/