Restylane Product Line – Each Variation Explained

David Fuller

Last Updated On: August 26, 2025

Hyaluronic acid (HA) is a naturally occurring substance in the body that plays a crucial role in maintaining skin hydration, elasticity, and volume. Research shows that HA can bind up to 1,000 times its weight in water, making it an essential ingredient in aesthetic treatments designed to restore youthful appearance. Its effectiveness and safety profile have made it a foundation for many dermal filler products worldwide.

Building on this science, Restylane has emerged as one of the most recognized HA-based filler brands. Designed with different formulations to target specific aesthetic concerns, it offers tailored solutions for facial rejuvenation. From smoothing fine lines to enhancing lips or restoring lost volume, Restylane’s versatility continues to attract patients and practitioners alike.

In this article, we will explore the complete Restylane product line, breaking down each variation, its intended uses, benefits, and what makes it unique in the field of dermal fillers.

Key Takeaways

• Restylane is a trusted family of hyaluronic acid fillers that can treat wrinkles, volume loss, and facial contour concerns with natural-looking results.
• The line is built on two core gel technologies: NASHA for firmer structure and XpresHAn Technology™ for flexibility and movement in dynamic areas.
• Classic Restylane is versatile for correcting moderate to deep folds, like nasolabial folds and marionette lines, and practitioners can also use it for subtle lip definition.
• Lyft offers firmer support for cheeks, jawline, and hands, with results lasting up to 12–18 months depending on the treatment area.
• Refyne and Defyne target the areas of facial expression. Refyne addresses moderate lines, while Defyne targets deeper folds, both maintaining natural mobility.
• Silk is best for delicate lip enhancement and fine lines, while Kysse provides longer-lasting volume with soft, flexible movement.
• Contour’s formulation focuses on cheek shaping, and Eyelight is a targeted option for treating under-eye hollows, offering a brightened, refreshed look.
• Results generally last 6 to 18 months, depending on the product, treatment area, and individual metabolism. Some formulations offer longer duration in low-movement zones.
• All Restylane fillers are FDA-approved, biocompatible, and reversible with hyaluronidase, giving both practitioners and patients confidence and flexibility in treatment planning.
• With its wide range of formulations, Restylane supports highly personalized treatment, allowing skilled injectors to create outcomes that enhance facial features while maintaining expression and balance.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to buy Restylane online, contact our sales department for more information. 

Classic Restylane and Its Core Applications

Classic Restylane is the original formulation that helped establish the brand’s global reputation. Known for its balanced texture and reliable performance, it remains a cornerstone in aesthetic practice.

This medium-firm gel is especially effective for treating moderate to severe facial wrinkles and folds, while maintaining a natural appearance that doesn’t look overdone.

Common Treatment Areas

• Nasolabial folds (lines running from the nose to the corners of the mouth)
  
• Marionette lines (creases from the mouth to the chin)
  
• Mild lip enhancement for subtle shape and contour

What makes Classic Restylane unique is its use of NASHA technology (Non-Animal Stabilized Hyaluronic Acid), which creates a smooth, cohesive gel that integrates predictably with the skin.

Longevity and Performance

• Most patients see results lasting 6 to 9 months
  
• In some areas, like the nasolabial folds, Galderma data supports results up to 18 months when retreatment is performed around 4.5 to 9 months
  
• Duration depends on the injection site, technique, and individual metabolism

Although newer Restylane products offer more specialized features, Classic Restylane remains a go-to for its versatility, consistency, and ease of use.

For those seeking lip refinement without volume-heavy results, Restylane in the lips using the original formula provides subtle enhancement. It’s ideal for patients who want to softly define their lip borders or restore shape without dramatic plumping.

Restylane Lyft, Refyne, and Defyne for Midface and Dynamic Wrinkles

Addressing midface volume loss, contour changes, and expression-related lines calls for a filler that not only adds structure but also moves with the face. The Restylane range includes Lyft, Refyne, and Defyne — each tailored for specific depths and degrees of movement.

Lyft

• Designed for deep injection into the cheeks, jawline, and dorsal hands.
  
• Formulated with larger gel particles, it provides lift and support in areas with visible sagging or hollowing.
  
• Well-suited for restoring midface structure and creating more defined contours.
  
• In clinical studies, results have been shown to last up to 12 months in the cheeks and up to 18 months in nasolabial folds. In the hands, the duration may be closer to 6 months.

Refyne

• Created with XpresHAn Technology, giving the gel a flexible quality that adapts to facial movement.
  
• Best for treating moderate wrinkles and smile lines, particularly around high-mobility zones like the mouth.
  
• Offers soft correction without disrupting natural expression, making it ideal for patients who want visible results that still move with the face.

Defyne

• Also built with XpresHAn Technology, but with a firmer structure than Refyne.
  
• Targets deeper folds — including nasolabial folds and marionette lines — while maintaining a natural feel.
  
• Provides both support and flexibility, helping patients avoid a “frozen” appearance even when treating significant wrinkles.

Together, these three fillers offer a layered approach to facial rejuvenation. Practitioners can choose based on wrinkle depth, anatomical location, and the patient’s desired level of correction, enabling a tailored outcome that enhances without overcorrecting.

Specialized Restylane Products: Silk, Kysse, Contour, and Eyelight

Beyond the midface and folds, the Restylane line includes highly specialized formulations for lips, cheeks, and under-eye concerns. Each one is designed with specific gel properties and treatment goals in mind.

Silk

• A lightweight filler created for fine detail work.
  
• Ideal for soft lip enhancement and smoothing fine lines around the mouth.
  
• Its smaller particle size allows for precision in areas where a delicate touch is needed.
  
• A favorite among patients who want subtle definition without added bulk.

Kysse

• Built with XpresHAn Technology for softness and flexibility.
  
• Provides natural volume while allowing for smooth, expressive movement.
  
• Results have been shown to last up to one year, depending on lifestyle and metabolism.
  
• Often preferred by patients looking for enhanced lips that still feel and move naturally.

Contour

• Designed for cheek augmentation and midface contouring.
  
• Offers lift and shape while blending seamlessly with surrounding tissue.
  
• Its formulation helps create subtle curves and definition, restoring youthful structure to the midface.

Eyelight

• A newer addition, cleared by the FDA in 2023 for use in the under-eye area.
  
• Specifically targets tear trough hollows, helping reduce shadows and a tired appearance.
  
• Long-term durability data is still emerging, but early results are promising for patients seeking under-eye brightness without surgery.

These targeted products represent the continued innovation and expansion of the Restylane portfolio — giving practitioners more control and patients more choice for precise, natural-looking enhancements.

Choosing the Right Restylane Product for Each Patient

With so many options, selecting the right Restylane product depends on several key factors: the treatment area, wrinkle severity, desired longevity, and the patient’s anatomy and goals.

• For fine lines and lip definition, practitioners often select Restylane Silk for its refined touch.
  
• For fuller lips that still move naturally, they commonly prefer Kysse.
  
• Patients looking for cheek lift or midface contouring may benefit most from Contour or Lyft.
  
• Eyelight works best for patients with under-eye hollowing or shadowing, offering a non-surgical alternative.
  
• Refyne is ideal for moderate expression lines, while Defyne provides greater support for deeper folds.
  
• Classic Restylane remains a dependable option for nasolabial folds, marionette lines, and mild lip enhancement.

An experienced practitioner will evaluate the entire face and offer a personalized plan. In many cases, combining products leads to the best outcome — for example, using Lyft in the cheeks alongside Kysse in the lips to restore balance and harmony across the mid and lower face.

This ability to customize treatments across different areas is what makes the Restylane family stand out. With precise application and realistic expectations, patients can achieve results that are rejuvenating without appearing overdone.

Conclusion

The Restylane product line continues to lead the field in customizable facial rejuvenation, offering a wide range of solutions designed to meet diverse aesthetic needs. Whether it’s restoring cheek volume, smoothing expression lines, defining lips, or addressing under-eye shadows, each formulation delivers natural-looking, reliable results tailored to the individual.

Restylane fillers are known for their versatility, long-standing safety record, and adaptability, with most products delivering improvements that last from 6 to 18 months depending on the area and formulation. Their reversibility with hyaluronidase adds an extra layer of reassurance for patients, particularly those new to filler treatments.

At the heart of Restylane’s success is its ability to support individualized treatment planning. With careful selection and expert injection, patients can enjoy refreshed, confident results that look and feel entirely their own.

FAQs

1. How long do Restylane fillers typically last?

Most Restylane fillers last six to twelve months, while some, like Lyft and Kysse, may last up to eighteen months, depending on metabolism, treatment area, and lifestyle.

2. Is Restylane safe for lip enhancement?

Yes. Restylane fillers like Silk and Kysse are specifically designed for lips. They have FDA approval and come from hyaluronic acid, ensuring natural integration and a low risk of adverse reactions.

3. What makes Restylane different from other filler brands?

Restylane’s broad product line and use of NASHA and XpresHAn technologies provide versatility, natural movement, and tailored solutions for various facial areas. This distinguishes it from many competitors.

4. If I’m not satisfied with the results, can I get my treatment reversed?

Yes. Hyaluronidase can dissolve Restylane safely and effectively. This reversibility offers reassurance, especially for first-time patients who may be concerned about committing to long-lasting results.

References

Hong GW, Wan J, Park Y, Chang K, Chan LKW, Lee KWA, Yi KH. Rheological characteristics of hyaluronic acid fillers as viscoelastic substances. Polymers. 2024;16(16):2386.

Sundaram MH, Michaels JM. Rheological evaluation of the physical properties of hyaluronic acid dermal fillers. J Drugs Dermatol. 2011;10:974-980.