Juvederm and Radiesse – The Perfect Combo for Cheeks and Jawline

David Fuller

Last Updated On: September 29, 2025

As a professional in the medspa industry, you know that no single filler can meet every patient’s needs. While filler sequencing is not a new concept, many practitioners have recently turned to using Juvederm and Radiesse in combination. This approach pairs the hydrating, volumizing qualities of hyaluronic acid with the structural support and collagen stimulation of calcium hydroxylapatite, creating tailored, long-lasting sculpting outcomes—particularly in the cheeks and jawline.

Key Takeaways:

• The sequential use of HA and CaHA fillers is becoming more common among medical professionals in the aesthetic industry.
• While limited studies are available, and new are possibly yet to emerge, those studies conducted using HA and CaHA filler synergistic technique showed a visible boost in skin appearance, enhanced dermal thickness and a longer-lasting structural support in the jaw and cheek area.
• Note that treatment strategies should be personalized based on anatomy, skin quality, and patient goals, balancing deep vs superficial filler placement.
• Products to consider for the sequential filler technique are Juvederm and Radiesse, both acting synergistically to deliver immediate volumization, deep structural support, and long-lasting rejuvenation.

About Sequential Filler Use

Sequential filler administration, generally speaking, involves the strategic use of different dermal fillers. Recently, medical professionals have begun to combine the use of hyaluronic acid (HA) like Juvederm, and calcium hydroxylapatite (CaHA) like Radiesse, for fillers targeting cheeks and jawline areas, as this practice helps personalize treatments in patients who need the benefits of both, and offers a long-term contour permanence. 

Studies conducted showed an improvement in patients within the 180-day period, and a great satisfaction in patients who underwent the assessment, and experience shows that the filler synergistic technique provides longer-lasting structural support in the targeted areas, enhancing dermal thickness and boosting skin appearance.

If you are interested in combining HA and CaHA in your professional practice and are opting for Juvederm and Radiesse, Med Supply Solutions is the place to start, offering both products straight from licensed sources at the best wholesale prices.

The Filler Synergistic Administration Technique

Note that the sequential technique should be applied on by experienced professionals from the medspa industry, using high quality products like Juvederm and Radiesse from reputable sources. 

As used in studies, to ensure soft tissue hydration and structural lift, it is recommended to start with the premixed hybrid formulation, by placing the contents of the CaHA syringe and the HA syringe in an empty syringe, adding 0.5. cc of lidocaine per 1.5 cc of CaHA if needed, and then joining the syringe with another to transform the mixture at least 10 times for full homogeneity and then injecting in the cheek or jawline area using a fanning technique.

It’s important to have in mind that the ratio of the products used is variable – and should be created following experience as well as patient’s indication. 

As for the post-procedure maintenance, patients can usually return to their daily schedules immediately after treatment, as its side effects are usually minor and show up as minor swelling, but they should be advised to stay out of the sun and use SPF protection, as well as to avoid using make-up and restrain from exercise for 24-48 hours post-treatment.

Why Combine Juvederm with Radiesse?

If you’re looking to implement a combination filler volumization strategy in your practice, Juvederm and Radiesse are great solutions for pairing. 

These two fillers complement each other by targeting different layers of facial aging and providing results that are both immediate and long-lasting. 

Juvederm is designed to restore midface volume and create a natural lift, making it particularly effective in areas such as the cheeks. On the other hand, Radiesse, a CaHA-based collagen stimulator, delivers deep structural reinforcement, acting as a jawline structural scaffold while stimulating the body’s own collagen production for results that continue to improve over time.

When used sequentially or as a carefully prepared hybrid mix, this pairing balances the unique benefits of hyaluronic acid and calcium hydroxylapatite. Juvederm hydrates and refines superficial contours, while Radiesse works deeper to build definition and ensure long-term contour permanence. Together, they address both the soft tissue and structural components of aging, offering patients natural-looking improvements that feel harmonious rather than overdone.

Overall benefits of both products mentioned are: 

• Fast procedure, lasting cca 40 minutes
• Long-lasting effects, of up to 12 months
• Improved collagen stimulation, enhanced over time
• Tailored results, easily customizable

For medspa professionals, combining these fillers means the ability to both customize and personalize treatments with an even better precision, helping patients achieve the desired results. 

Note that you can buy both Juvederm and Radiesse at Med Supply Solutions, if you are looking to incorporate them into your practice. 

Ideal Candidates for Juvederm and Radiesse Combo

Not every patient is an ideal candidate for sequential filler administration, which is why careful assessment and planning are essential before implementing this technique. 

The decision to combine Juvederm and Radiesse should be based on a thorough evaluation of facial anatomy, overall skin health and quality no matter the age, as well as the patient’s medical history and desired outcome. 

The indications for the use of Juvederm and Radiesse include:

• Definition and enhancement of the jawline 
• Restoration of volume and contour in the midface area
• Skin hydration improvement
• Correction of moderate to severe facial wrinkles

Contraindications for the use of Juvederm and Radiesse include:

• Known hypersensitivity to any filler components
• History of allergic reactions
• Active skin infections or inflammation on the treatment area

As with all dermal filler procedures, patients who are pregnant or breastfeeding are not eligible for these treatments. 

It’s important to mention that the combination of these two fillers does not act as a substitute in cases of extreme skin laxity or needs for structural changes. That’s why a clear and personalized plan and a thorough preparation ensures safety and alignment with the desired outcome.

Side Effects of the Juvederm and Radiesse Combo

As with all dermal filler procedures, there are some possible but generally minor side effects to using the Juvederm and Radiesse combination, which typically disappear within a few days. To minimize risks and avoid any serious complications, it’s crucial for the administration process to be conducted by a skilled and experienced medspa professional, who can carefully monitor the patient and promptly address any potential issues. 

Side effects of the Juvederm and Radiesse combination may include skin reactions on the targeted area, such as:

• Redness
• Swelling
• Tenderness
• Itching

More serious complications, including infections, scarring, and allergic reactions, are rare occurrences. 

The Duration of the Juvederm and Radiesse Combo

One of the key advantages of combining Juvederm and Radiesse is the balance between immediate results and long-term improvements. 

The longevity of results will vary depending on several factors, including the patient’s overall wellbeing, lifestyle, and even the depth of injection. Generally speaking, Juvederm can last up to 12 months, while Radiesse provides structural support for 18–24 months or longer. Combining the two allows patients to experience a more continuous effect.

Maintenance is an important aspect of sequential filler treatments. Periodic touch-ups, done once or twice a year, can help preserve optimal results. These sessions are opportunities to correct minor changes in facial volume, enhance contours, and ensure symmetry. Patient education is key: individuals should understand that while fillers are not a permanent solution, a consistent maintenance plan can extend the aesthetic benefits and keep results looking natural. 

Conclusion:

Although the data on the sequential filler layering is limited, experience shows that combining HA and CaHA preserves the benefits of both, giving patients a longer-lasting, natural effect that’s better tailored to their needs. 

Fillers like Juvederm and Radiesse enhance results by working in synergy—delivering structure, volume, and rejuvenation in a way that looks and feels effortless.

If you’re interested in offering this combination in your practice, contact Med Supply Solutions. From cosmetic injectables to a wide range of aesthetic solutions for medical professionals, we provide customers worldwide with high-quality products from trusted brands.

FAQ

1. Can you inject Juvederm and Radiesse sequentially?

Yes, sequential use of Juvederm (HA) and Radiesse (CaHA) is commonly practiced to combine immediate volumization with long-term structural support.

2. What are the benefits of sequential use of dermal fillers?

Sequential use of dermal fillers combines a tailored approach to patients needs, and by combining e.g. Juvederm with Radiesse, patients can enjoy immediate volumization, enhanced structural support, long-lasting rejuvenation, and natural-looking results

3. Where can I buy Juvederm?

As a medical professional, you can buy Juvederm from Med Supply Solutions. 

4. Where can I order Radiesse?

You can order Radiesse at wholesale prices from Med Supply Solutions. 

5. What are the side-effects of the Juvederm and Radiesse combo?

The side effects of the Juvederm and Radiesse combination are mild and include skin reactions on the injection site, while serious complications are rare and usually a result of an unprofessional treatment.

References:

Fakih-Gomez N, Kadouch J. Combining Calcium Hydroxylapatite and Hyaluronic Acid Fillers for Aesthetic Indications: Efficacy of an Innovative Hybrid Filler. Aesthetic Plastic Surgery. Published online August 2, 2021. doi:https://doi.org/10.1007/s00266-021-02479-x

Bravo B, Carvalho R, Bravo L, Penedo L, Elias M. Blending Hyaluronic Acid and Calcium Hydroxylapatite for Injectable Facial Dermal Fillers: A Clinical and Ultrasonography Assessment. Cosmetics. 2024;11(2):61. doi:https://doi.org/10.3390/cosmetics11020061

Hall C. Optimizing Facial Aesthetics: Sequential Application of Botulinum Toxin A and Dermal Fillers for Enhanced Results. Plastic and aesthetic nursing. 2024;44(1):70-71. doi:https://doi.org/10.1097/psn.0000000000000546

DrSkin Medspa. DrSkin Plastic Surgery, Regenerative & Medical Spa. DrSkin Plastic Surgery, Regenerative & Medical Spa. Published November 19, 2024. Accessed September 6, 2025. https://drskinmedspa.com/can-you-mix-fillers-in-your-face-a-guide-to-combining-dermal-fillers/

mrktmade. Juvederm Filler and Other Treatments It Can Be Combined With. Skin Deep Med Spa. Published May 19, 2023. https://www.skindeepmedspa.com/what-other-treatments-can-be-combined-with-juvederm/

Staff W. Juvederm vs. Radiesse: What’s The Difference? Westlake Dermatology & Cosmetic Surgery®. Published January 6, 2020. Accessed September 8, 2025. https://www.westlakedermatology.com/blog/juvederm-vs-radiesse/