Plinest vs Profhilo – What’s the Difference?

Last Updated On: June 16, 2025

Injectable treatments for skin rejuvenation have skyrocketed in popularity, becoming a go-to solution for individuals seeking a non-surgical approach to a more youthful appearance. Recent market projections show the sector is on track to grow at an impressive compound annual growth rate (CAGR) of approximately 15.40%, underscoring the increasing demand for facial injections and other non-invasive cosmetic procedures.

Among the numerous options available today, Plinest and Profhilo have gained significant attention for their ability to revitalize and restore the skin through innovative biostimulatory techniques. Despite their shared goal of skin rejuvenation, these two treatments are distinct in their formulations and mechanisms. Plinest and Profhilo utilize different ingredients and work in unique ways, offering tailored benefits depending on individual skin concerns.

In this article, we’ll dive into the key differences between Plinest and Profhilo, exploring their benefits, and helping you determine which treatment is best suited for your skin’s specific needs.

Key Takeaways

• Plinest and Profhilo are both injectable treatments designed for skin rejuvenation, but they work through different mechanisms and are ideal for various skin concerns.
• Plinest is a polynucleotide-based injectable that stimulates fibroblast activity, promoting long-term collagen and elastin production. It’s best suited for deeper dermal remodeling, treating fine lines, scarring, and sun-damaged skin.
• Profhilo uses a hyaluronic acid-based formula that increases skin hydration and elasticity by stimulating the body’s natural production of hyaluronic acid. It’s ideal for enhancing skin tone, tightening, and providing a quick hydration boost.
• Injection depth is a key differentiator: Plinest is injected into deeper dermal or subdermal layers, while Profhilo is placed in the superficial dermis for more immediate effects.
• Downtime and patient comfort vary: Plinest may cause mild swelling and bruising, while Profhilo generally has minimal downtime, making it the go-to for a quicker rejuvenation solution.
• Combining Plinest and Profhilo can offer complementary benefits, with Profhilo providing superficial hydration and Plinest offering deeper structural repair, resulting in a well-rounded approach to skin rejuvenation.
• Choosing between these treatments depends on factors such as skin type, concerns, desired results, and the level of rejuvenation required. 

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to buy Plinest Fillers online, contact our sales department for more information.  

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How the Two Treatments Work at a Cellular Level

Plinest is a polynucleotide-based injectable that works by stimulating fibroblasts and promoting the release of growth factors. This process enhances the production of collagen and elastin, essential proteins that contribute to maintaining skin firmness and elasticity. 

The DNA fragments in Plinest provide powerful antioxidant and anti-inflammatory benefits, which make it especially effective for skin repair and remodeling. Through these cellular mechanisms, Plinest helps address deeper skin concerns, such as fine lines and scarring, by offering long-term regenerative benefits.

On the other hand, Profhilo is formulated with a patented NAHYCO® H.A. hybrid complex, combining both high- and low-molecular-weight hyaluronic acid. This unique composition stimulates the body’s natural production of hyaluronic acid, enhancing skin hydration and improving elasticity. 

Profhilo primarily works on the surface, enhancing skin tone and delivering a tightening effect that results from increased moisture retention. This makes Profhilo especially effective for those seeking a quick boost in hydration and skin radiance.

Together, these differences highlight how Plinest and Profhilo serve distinct roles in skin rejuvenation. While Plinest focuses on long-term structural repair and anti-inflammatory benefits at a deeper level, Profhilo delivers faster hydration and superficial skin tightening. 

Differences in Indications, Depth, and Injection Sites

When comparing Plinest and Profhilo, understanding their key features can help clarify their ideal applications in aesthetic treatments. Both injectables are designed for skin rejuvenation, but their composition, depth of action, and delivery methods vary, influencing how they address various skin concerns and the injection techniques used.

Plinest treatments typically involve intradermal or subdermal injections using small volumes per injection point. In contrast, Profhilo follows a protocol involving deeper but fewer injection sites, designed for optimal gel diffusion with minimal invasiveness. Understanding these procedural nuances ensures that practitioners can tailor treatment plans to meet the individual needs and desired outcomes of each patient.

Patient Experience: Pain, Downtime, and Number of Sessions

Patient comfort and treatment logistics play a crucial role in determining the choice between Plinest and Profhilo. Both products offer effective skin rejuvenation, but differences in needle size, injection technique, and formulation viscosity can influence pain levels, downtime, and the overall treatment experience.

Pain and Comfort

Plinest uses thin needles and applies conservative injection pressure, which leads to light pricking sensations but minimal overall pain. The fine needle gauge and careful technique help reduce discomfort, even in sensitive areas like the under-eye and neck.

Profhilo injections use a slightly thicker needle, causing more noticeable pricking sensations. However, cooling creams or topical anesthetics are often applied before treatment to alleviate needle discomfort, making the procedure tolerable for most patients.

Downtime

Plinest’s higher viscosity formulation can lead to mild redness, bruising, or swelling, particularly in areas where the gel is denser. These side effects typically resolve within 1 to 3 days, allowing patients to resume normal activities promptly.

Profhilo, with its lighter texture and fewer injection points, typically causes less post-injection irritation. Most patients experience little to no downtime, often returning to their daily routines immediately after treatment.

Treatment Schedule

Plinest treatments usually involve 2 to 3 sessions, spaced 3 to 4 weeks apart. Maintenance sessions are recommended every 4 to 6 months to sustain collagen stimulation and dermal remodeling.

Profhilo requires fewer initial sessions, with two treatments spaced approximately one month apart. Follow-up refreshers every 4 to 6 months help maintain hydration and skin tightening effects.

Profhilo is better suited for those seeking quick, hydrating refreshers with minimal discomfort and downtime. In contrast, Plinest offers a more intensive approach focused on long-term skin structure enhancement. For those weighing their options, they can compare other treatments, such as Plinest vs Nucleofill, to determine which product best suits their individual skin needs and treatment goals.

Can Plinest and Profhilo Be Combined?

Yes, combining Plinest and Profhilo can offer complementary benefits. While Profhilo hydrates and lifts superficially, Plinest stimulates deeper structural repair and collagen enhancement. This combination can create a well-rounded rejuvenation approach.

Combination Protocol

• Session 1: Profhilo for immediate hydration.
• Session 2 (2–4 weeks later): Plinest to support fibroblast activation and skin resilience.
• Maintenance: Alternate boosters depending on the skin’s condition (every 4–6 months).

This dual approach is ideal for patients needing both lifting and structural regeneration. Those seeking to target skin hydration, firmness, and texture can benefit significantly from this combination.

Conclusion

When choosing between Plinest vs Profhilo, the decision largely depends on your aesthetic goals. Plinest is ideal for structural repair, improving skin texture, or correcting scars. Its deeper action promotes collagen and elastin production, making it suitable for more intensive skin remodeling and addressing photo-damage or scarring.

In contrast, Profhilo is perfect for those seeking enhanced hydration, radiant skin, and a gentle lifting effect. Its lighter formula works on superficial layers, improving skin elasticity and moisture. Some patients may find that combining both treatments yields the best results, addressing a range of concerns from hydration to structural regeneration. 

Always consult a trained practitioner to tailor the treatment plan to your skin type, concerns, and expectations.

FAQs

1. Can I use Plinest after Profhilo?

Yes. Start with Profhilo for hydration and follow with Plinest to enhance collagen and improve skin texture.

2. Which is better for under-eye fine lines?

Plinest is often preferred due to its smaller particle size and tissue-regenerative effects in delicate periorbital areas.

3. Are there risks or any side effects?

Commonly, mild redness, swelling, or bruising. These typically resolve within a few days. Rare allergic reactions may occur.

4. How soon can I expect to see results?

Profhilo offers hydrating effects within a few days, while Plinest shows structural improvements, such as improved tone and elasticity, over 4–6 weeks.

References

Grandview Research. Non-invasive Aesthetic Treatment Market Size Report, 2030. https://www.grandviewresearch.com/industry-analysis/non-invasive-aesthetic-treatment-market

Carruthers JD, Glogau RG, Blitzer A. Advances in facial rejuvenation: botulinum toxin type A, hyaluronic acid dermal fillers, and combination therapies—consensus recommendations. Plast Reconstr Surg. 2008;121(5):5S-30S.

Trovato F, Ceccarelli S, Michelini S, et al. Advancements in Regenerative Medicine for Aesthetic Dermatology: A Comprehensive review and future Trends. Cosmetics. 2024;11(2):49. doi:10.3390/cosmetics11020049