Lanluma Protocol – Administration Techniques and Dosing

David Fuller

Last Updated On: May 20, 2025

A 2024 post-market study on poly-L-lactic acid (PLLA) injectables highlighted the significance of structured dosing protocols in achieving consistent aesthetic outcomes. Patients who adhered to a schedule of injections at baseline, 3 months, and 6 months experienced superior results with a lower incidence of adverse effects. These findings emphasize the pivotal role of precise dosing and skilled administration techniques in optimizing treatment success.

Building on these insights, Lanluma offers a refined approach to collagen stimulation, designed to enhance body contours and skin quality through gradual, natural-looking improvements. Its efficacy, however, depends heavily on meticulous preparation and accurate application, making practitioner expertise critical to treatment outcomes.

This article delves into the Lanluma protocol, providing a comprehensive guide to administration techniques, dosing guidelines, and post-treatment care—ensuring safe, effective, and predictable results with this innovative biostimulatory injectable.

Key Takeaways

• Lanluma is a poly-L-lactic acid (PLLA) collagen biostimulator designed for gradual, natural-looking facial rejuvenation and body contouring by stimulating the body’s own collagen production.
• Correct reconstitution requires 40–60 mL of sterile water per vial, hydration for at least 12 hours (up to 72 hours for optimal results) and gentle mixing to ensure a smooth suspension.
• Injection techniques focus on deep subcutaneous or supraperiosteal placement, preferably using blunt cannulas, with fanning or crosshatching methods to ensure even product distribution and minimize risks.
• A structured treatment plan typically involves 2 to 3 sessions for facial areas and 2 to 4 sessions for body contouring, spaced 4 to 6 weeks apart, with full results developing over 3 to 6 months and lasting up to 2 years.
• Post-treatment massage following the 5-5-5 rule (5 minutes, 5 times daily, for 5 days) is crucial for even collagen stimulation and preventing nodule formation.
• Aftercare recommendations include avoiding strenuous activities, alcohol, saunas, and direct sun exposure for several days post-injection to support proper healing and results.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. Contact our sales department for more information if you want to buy Lanluma Fillers online.  

Reconstitution Guidelines and Preparation for Lanluma Treatments

Proper reconstitution of Lanluma is the foundation of a successful treatment. Ensuring a well-hydrated and evenly mixed solution maximizes collagen stimulation while minimizing patient discomfort and procedural complications. Lanluma is available in two formulations—Lanluma V (for facial areas) and Lanluma X (for larger body areas)—each requiring specific reconstitution volumes to achieve optimal consistency.

The reconstitution steps for Lanluma include:

• Depending on the treatment indication, add 40–60 mL of sterile water for injection (SWFI) per vial.
• Hydrate the vial for at least 12 hours before use (up to 72 hours for best particle dispersion).
• Gently shake or vortex mix to achieve uniformity.
• Use bacteriostatic water if the product will be stored post-hydration.

After hydration, the product remains viable for up to 72 hours. Prior to administration, gently invert or shake the vial again to ensure particle redistribution. This careful preparation prevents clumping, reduces injection discomfort, and enhances the even stimulation of fibroblast activity within the targeted tissue.

Injection Techniques and Depth Considerations When Using Lanluma

Effective Lanluma administration relies on precise injection techniques tailored to each treatment area. The objective is to place PLLA microspheres at an appropriate depth where they can stimulate collagen production without causing nodule formation or surface irregularities.

Some key considerations healthcare practitioners should remember are the following:

• Injection Plane: Deep subcutaneous or supraperiosteal layers for optimal collagen stimulation.
• Cannula vs. Needle: Blunt-tip cannulas (22G or 25G) are preferred for safety and even product distribution, while needles may be used with extra caution.
• Fanning or Crosshatching: Techniques that promote uniform spread of PLLA particles and reduce the risk of over-concentration.
• Aspiration: Always aspirate when using a needle to avoid accidental intravascular injection.

Due to its biostimulatory nature, Lanluma requires slow, controlled injections, allowing the product to settle smoothly within the tissue. Overfilling should be avoided, as Lanluma’s effects develop progressively, with volume enhancement and contour refinement occurring over time.

Treatment Session Planning and Collagen Stimulation Timeline with Lanluma

To fully understand the Lanluma protocol, it’s important to revisit what is Lanluma—a collagen biostimulator that restores volume and improves skin texture by enhancing the body’s natural regenerative processes. Unlike hyaluronic acid fillers, Lanluma’s results are not immediate but build gradually, offering subtle, long-lasting improvements.

Treatment Factor	Details
Recommended Sessions	2 to 3 sessions for facial treatments2 to 4 sessions for body areas
Interval Between Sessions	4 to 6 weeks between each session
Initial Visible Results	Begin appearing 6–8 weeks after the first session
Full Results Timeline	Continued collagen improvement over 3–6 months
Longevity of Results	Can last up to 2 years post-treatment
Personalization Factors	Age, skin laxity, and desired enhancement affect the number of vials and sessions

Customizing the number of vials and sessions based on individual skin quality and aesthetic goals ensures predictable, natural-looking outcomes. This gradual improvement process makes Lanluma ideal for patients seeking refined contouring without sudden, dramatic changes.

Post-Treatment Massage and Aftercare Following Lanluma Injections

Post-treatment care is an integral part of the Lanluma protocol. It ensures optimal product distribution and reduces the risk of nodules or uneven results. One of the most important aftercare practices is patient-guided massage of the treated area.

Clinicians should emphasize the 5-5-5 rule:

• 5 minutes of massage
• 5 times per day
• For 5 consecutive days

Firm, circular motions combined with a moisturizing lotion can make this routine more comfortable and effective. Proper massage helps disperse PLLA microspheres evenly, promoting smooth collagen deposition.

Additional aftercare recommendations include:

• Avoiding strenuous activities and alcohol for at least 24 hours post-injection.
• Refraining from using saunas and avoiding direct sun exposure for a minimum of 3 days.
• Educating patients that mild bruising, swelling, or tenderness may occur but typically resolves within a few days.

By thoroughly explaining these steps, practitioners foster better patient compliance, which is crucial for maximizing the aesthetic benefits of Lanluma treatments while minimizing potential complications.

Conclusion

Mastering the Lanluma protocol is essential for achieving safe, effective, and natural-looking results. From accurate reconstitution to skilled injection techniques and diligent post-treatment aftercare, each step contributes to the success of this biostimulatory treatment. Unlike conventional fillers, Lanluma offers a gradual, regenerative approach to facial and body contouring, delivering long-term improvements through collagen stimulation.

When performed with precision and care, Lanluma becomes a valuable tool for practitioners seeking to offer subtle yet lasting enhancements tailored to each patient’s unique aesthetic goals.

FAQs

1. How long do Lanluma results last?

Lanluma results can last up to two years. Since it stimulates your body’s collagen, improvements are gradual but long-lasting.

2. Is Lanluma safe for all areas of the body?

Lanluma V is approved for facial and small-area treatments, while Lanluma X is suited for larger body areas like the buttocks. Always consult a trained practitioner to determine suitability.

3. How soon can patients return to work after a Lanluma treatment?

Most patients return to normal activities within 24–48 hours. Mild swelling or bruising is common but temporary.

4. What happens if the post-treatment massage is skipped?

Skipping a massage increases the risk of lump formation or uneven collagen production. Following the 5-5-5 massage rule is crucial for even results.

References

Amselem M, Fatsea D, Forte R, Hasenöhrl C, Haus A, Salaabian A. Safety and effectiveness results of an innovative injectable poly‐L‐lactic acid‐based collagen stimulator (Lanluma®)—Clinical outcomes at 9 months in a post‐market study. Journal of Cosmetic Dermatology. Published online September 4, 2024. doi:10.1111/jocd.16527

Wu L, Salti G. Combined Forehead and Temporal Lifting: An Innovative Approach to Lanluma V Treatment. J Cosmet Dermatol. 2025;24(1):e16583. doi:10.1111/jocd.16583