The 12.5 mg dose is an intermediate escalation step in the tirzepatide titration schedule, following the 10 mg level when additional dose advancement is indicated. MOUNJARO® 12.5 mg KwikPen® is administered once weekly by subcutaneous injection, at any time of day, with or without food. Injection sites are the abdomen, thigh, or — when another person administers the dose — the back of the upper arm. Sites should be rotated with each dose.
Tirzepatide titration begins at 2.5 mg once weekly for 4 weeks, then increases to 5 mg. If additional glycemic response is needed, the dose may be increased by 2.5 mg increments after at least 4 weeks on the current dose, up to a maximum of 15 mg once weekly.
If a dose is missed, it may be administered within 4 days (96 hours) of the scheduled date. If more than 4 days have passed, skip the missed dose and resume the regular weekly schedule. When using MOUNJARO® with insulin, administer as separate injections and never mix. Both injections may be given in the same body region but not adjacent to each other. For information on other MOUNJARO® KwikPen® doses, contact the Med Supply Solutions team.