INTRALINE® M4 PLUS is designed to be injected into the deep dermis and subcutaneous tissue for the correction of deep wrinkles and volume loss. The product should be injected slowly and carefully, with no more than 3 ml per treatment area to avoid over-correction. The syringe contains 1.1 ml of gel, and the treatment is generally performed with 25G and 27G needles. For optimal outcomes, the product can be used in conjunction with other Intraline fillers for comprehensive facial rejuvenation. A follow-up session may be needed, and the effect usually lasts for 6–18 months, based on factors like skin type, the area of injection, and lifestyle.

Key Features:

• Monophasic gel for smoother, more natural results.
• Cross-linked HA ensures long-lasting effects.
• Contains lidocaine (3 mg/ml) for a more comfortable injection.
• High viscosity for deep wrinkles and facial contouring.
• 1.1 ml per syringe, with needles included for ease of application.
• CE-approved: Guarantees high safety and quality standards.

INTRALINE® M4 PLUS is indicated for deep-set wrinkles, such as nasolabial folds, marionette lines, and areas of volume loss in the face, particularly the cheeks, chin, and jawline. It can also be used for non-surgical rhinoplasty to enhance nose definition or adjust the nose shape subtly. It is beneficial for those seeking facial contouring or restoration of facial volume lost due to aging or other factors. This filler is suitable for patients with moderate to severe facial wrinkles or those who require a more pronounced lift in the face.

Indications:

• Facial contouring: Ideal for enhancing the cheeks, jawline, and chin.
• Deep wrinkles: Effective for treating nasolabial folds, marionette lines, and deep-set lines around the mouth.
• Non-surgical rhinoplasty: Suitable for enhancing the shape and definition of the nose.
• Volume restoration: Replenishes volume in areas affected by aging or fat loss.

Contraindications:

• Hypersensitivity to hyaluronic acid or lidocaine.
• Active skin infections or skin diseases at the injection site.
• Pregnancy or breastfeeding: Not recommended for use during these periods.
• Severe allergies or autoimmune diseases may limit suitability.

Side Effects:

• Common: Swelling, bruising, redness, or tenderness at the injection site.
• Uncommon: Itching, mild discomfort, or temporary numbness.

Rare: Allergic reactions, vascular occlusion, or skin necrosis if injected incorrectly.

INTRALINE® M4 PLUS is made of high-quality, non-animal-derived hyaluronic acid that mimics the natural HA found in the body. It is produced using bio-fermentation, ensuring that the HA is biocompatible and safe for patients. The filler is cross-linked using BDDE (1,4-butanediol diglycidyl ether), which provides stability and long-lasting effects. The inclusion of lidocaine (3 mg/ml) makes the product comfortable for patients, as it numbs the treatment area during injection. The high viscosity of the gel allows for precise placement in deep dermal layers, offering a natural lift to volume-deficient areas.

Ingredients:

• Hyaluronic acid (24 mg/ml): Hydrates and adds volume to the skin.
• Lidocaine (3 mg/ml): Provides local anesthesia to minimize pain during injection.
• Cross-linking agent (BDDE): Ensures product stability and longevity.
• Water for injection: Maintains the right consistency for easy injection and smooth integration.

Packaging:

• 1.1 ml syringe: Contains enough filler for one treatment area.
• 25G and 27G needles: Ensures precision and comfort during injection.
• Single-use: Guarantees sterility and safety for the patient.

INTRALINE® M4 PLUS should be injected by a qualified healthcare professional with experience in dermal filler treatments. The area to be treated should first be cleaned thoroughly with an antiseptic solution. The filler is injected slowly into the deep dermis and subcutaneous tissue using the 25G or 27G needles provided. The amount injected should be carefully controlled, with a maximum of 3 ml per site. After injection, gentle massage can be applied to ensure even distribution of the product. The treatment is minimally invasive, and patients can return to their daily activities immediately, although they should avoid strenuous exercise and direct sun exposure for a few days.

Step-by-Step Instructions:

1. Cleanse the skin: Prepare the treatment area by cleaning it with antiseptic.
2. Prepare the syringe: Attach the provided needle to the syringe and expel any air.
3. Inject the filler: Inject slowly into the deep dermis or subcutaneous layer, adjusting as necessary for a smooth and even result.
4. Massage the area: Gently massage the treated area to ensure even distribution of the product.
5. Post-treatment care: Apply ice to reduce swelling and avoid touching the treated area for at least 6 hours.

Frequency:

• A single treatment is often sufficient for significant results, though follow-up treatments may be required every 6 to 18 months, depending on the area treated and individual patient factors.

INTRALINE® M4 PLUS is a highly effective dermal filler that addresses deep wrinkles and volume loss, offering long-lasting and natural-looking results. The inclusion of lidocaine makes the injection process more comfortable, while its cross-linked hyaluronic acid ensures safety, biocompatibility, and lasting effects. It is suitable for a variety of facial rejuvenation treatments, making it an excellent choice for patients looking to restore facial volume and smooth out deep-set lines.