SS-31 peptide is a synthetic tetrapeptide, commonly referenced in scientific literature as Elamipretide or MTP-131. It is developed for controlled laboratory use and is frequently studied in relation to mitochondrial structure and function. Manufactured using established peptide synthesis methods, it undergoes purification and analytical verification to ensure consistency across research applications.
This compound is often included in experimental models that examine how targeted peptides interact with mitochondrial components involved in cellular energy processes and oxidative balance.
SS-31 (14mg) Key Features & Specs
- Subcategory: Longevity & Anti-Aging Peptides
- Strength: 14 mg
- CAS: 736992-21-5
- Chemical Formula: C₃₂H₄₉N₉O₅
- Molecular Weight: 639.8 g/mol
- Peptide Sequence: D-Arg-dimethyl-Tyr-Lys-Phe-NH₂
- Synonyms: MTP-131, Elamipretide
For laboratory research use only.
SS-31 (14mg) Research Uses
SS-31 research focuses on mitochondrial function and cellular energy dynamics in controlled laboratory settings. This peptide has been studied for its potential to associate with mitochondrial membranes and influence oxidative balance. Investigations often involve cellular and tissue models, particularly in energy-demanding systems such as cardiac and skeletal muscle.
Elamipretide peptide research also explores its relevance in metabolic activity and age-related cellular changes, contributing to a broader understanding of mitochondrial-associated processes.
SS-31 (14mg) Insights & Observed Findings
Preclinical studies involving SS-31 mitochondrial peptide models commonly assess activity in nanomolar to micromolar concentration ranges in vitro. In animal studies, dosing has been explored in microgram-per-kilogram (µg/kg) ranges, depending on the research objective.
Observations under controlled conditions have included changes in markers associated with mitochondrial structure, cellular energy production, and oxidative stress. These findings remain investigational and are used to support ongoing laboratory research.
SS-31 (14mg) Handling & Storage
- Recommended laboratory storage: 2–8 °C; –20 °C where applicable.
- Keep the lyophilized peptide protected from light, heat, and moisture prior to reconstitution.
- Reconstitute using sterile laboratory-grade solvents and handle using aseptic techniques.
- After reconstitution: Maintain the solution under refrigerated conditions and avoid repeated freeze-thaw cycles.
- Follow institutional laboratory protocols for additional guidance on handling.
Compliance Notice: This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in-vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.
References
- PubChem CID 11764719. National Center for Biotechnology Information. https://pubchem.ncbi.nlm.nih.gov/compound/Elamipretide
- Elamipretide: Uses, interactions, mechanism of action. DrugBank. https://go.drugbank.com/drugs/DB11981
- Birk AV, Liu S, Soong Y, et al. The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin. J Am Soc Nephrol. 2013;24(8):1250-1261. doi:10.1681/ASN.2012121216
- Tse BC, Dvoriantchikova G, Tao W, et al. Mitochondrial targeted therapy with elamipretide (MTP-131) as an adjunct to tumor necrosis factor inhibition for traumatic optic neuropathy in the acute setting. Exp Eye Res. 2020;199:108178. doi:10.1016/j.exer.2020.108178
- Brown DA, Hale SL, Baines CP, et al. Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia. J Cardiovasc Pharmacol Ther. 2014;19(1):121-132. doi:10.1177/1074248413508003
- Li M, Kong D, Meng L, Wang Z, Bai Z, Wu G. Discovery of novel SS-31 (d-Arg-dimethylTyr-Lys-Phe-NH2) derivatives as potent agents to ameliorate inflammation and increase mitochondrial ATP synthesis. RSC Adv. 2024;14(41):29789-29799. Published 2024 Sep 18. doi:10.1039/d4ra05517a