PT-141 (5mg) is a synthetic cyclic peptide belonging to the melanocortin peptide family. It is structurally derived from alpha-melanocyte-stimulating hormone (α-MSH) and contains modified amino acids to enhance its stability under experimental conditions. This peptide is commonly studied for its interaction with melanocortin-related signaling systems.
PT-141 has been investigated in laboratory settings focused on neuroendocrine communication and central signaling pathways.
PT-141 (5mg) Key Features & Specs
PT-141 (5mg) is prepared for use in controlled laboratory environments to ensure accurate peptide characterization and consistent experimental results. It is frequently included in research exploring how melanocortin peptides influence cellular signaling and communication pathways.
- Subcategory: Neuroendocrine & Melanocortin Research Peptides
- Strength: 5 mg
- CAS Number: 189691-06-3
- Chemical Formula: C₅₀H₆₈N₁₄O₁₀
- Molecular Weight: 1025.182 g/mol
- Peptide Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)
- Synonyms: PT141
For laboratory research use only.
PT-141 (5mg) Research Uses
PT-141 (5mg) has been investigated within laboratory environments focused on neuroendocrine signaling and melanocortin pathways. As a melanocortin peptide analog, it serves as a tool for exploring how peptide signaling influences communication within the central nervous system.
Research involving this peptide typically examines biological systems related to hormonal signaling, neuronal communication, and central regulatory pathways. These studies aim to understand the mechanisms by which melanocortin peptides interact with cellular systems that govern neuroendocrine function.
In experimental models, PT-141 is used to investigate how signaling molecules modulate cellular pathways involved in central signaling and peptide-mediated communication.
PT-141 (5mg) Insights & Observed Findings
Preclinical and in vitro studies involving melanocortin peptides such as PT-141 have evaluated activity across nanomolar concentration ranges, depending on the biological system and experimental design. These studies are conducted to assess peptide-mediated signaling responses.
Animal studies investigating melanocortin signaling have reported dosing ranges in the microgram per kilogram (µg/kg) scale. Experimental parameters may vary depending on the pathways and systems being studied.
Observed findings suggest that melanocortin-related peptides may influence molecular pathways involved in neuroendocrine signaling, cellular communication, and central regulatory processes. These findings remain under investigation and should not be interpreted as evidence of clinical outcomes.
PT-141 (5mg) Handling & Storage
- Store lyophilized powder at 2–8 °C or –20 °C in a controlled environment, protected from light, heat, and moisture.
- After reconstitution with sterile laboratory-grade solvent, store solution refrigerated (2–8°C).
- Avoid repeated freeze-thaw cycles. Use aseptic technique and follow institutional biosafety guidelines.
Compliance Notice: This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in-vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.
References
- National Center for Biotechnology Information. PubChem Compound Summary for CID 9941379, Bremelanotide. https://pubchem.ncbi.nlm.nih.gov/compound/Bremelanotide
- Molinoff PB, Shadiack AM, Earle D, Diamond LE, Quon CY. PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Ann N Y Acad Sci. 2003;994:96-102. doi:10.1111/j.1749-6632.2003.tb03167.x
- Wessells H, Blevins JE, Vanderah TW. Melanocortinergic control of penile erection. Peptides. 2005;26(10):1972-1977. doi:10.1016/j.peptides.2004.11.035
- Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. Int J Impot Res. 2004;16(2):135-142. doi:10.1038/sj.ijir.3901200