Melanotan 2 (MT2) (10mg) is a synthetic cyclic peptide derived from alpha-melanocyte-stimulating hormone (α-MSH). It features a modified amino acid sequence arranged in a cyclic structure, which contributes to its stability in laboratory environments. The peptide includes substitutions such as norleucine (Nle) and D-phenylalanine, which enhance its structural integrity for experimental use.
Research-grade Melanotan 2 is produced with high purity and verified by HPLC and mass spectrometry. It is supplied as a 10 mg lyophilized powder in a sealed research-grade vial and is used in laboratory studies investigating melanocortin signaling, cellular communication, and neuroendocrine pathways.
Melanotan 2 (MT2) (10mg) Key Features & Specs
- Subcategory: Melanocortin & Pigmentation Research Peptides
- Strength: 10 mg
- CAS Number: 121062-08-6
- Chemical Formula: C₅₀H₆₉N₁₅O₉
- Molecular Weight:198 g/mol
- Peptide Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
For laboratory research use only.
Melanotan 2 (MT2) (10mg) Research Uses
Melanotan 2 (MT2) (10mg) has been studied in laboratory environments focused on melanocortin signaling and neuroendocrine communication. As a cyclic analog of α-MSH, it is used in research exploring how peptide signaling influences cellular pathways involved in pigmentation and hormone-related processes.
Studies involving this peptide commonly examine biological systems such as skin cell signaling, neuroendocrine pathways, and cellular responses to signaling molecules. These investigations aim to understand how melanocortin peptides contribute to communication within biological systems.
In experimental models, Melanotan 2 is used to investigate how signaling peptides interact with cellular pathways involved in pigmentation biology and endocrine signaling mechanisms.
Melanotan 2 (MT2) (10mg) Insights & Observed Findings
Preclinical and in vitro studies of melanocortin peptides like Melanotan 2 have evaluated activity across nanomolar to micromolar concentration ranges, depending on the biological model and experimental conditions. These studies are primarily focused on examining cellular signaling responses.
Animal studies investigating peptide-mediated signaling have reported dosing ranges in the microgram per kilogram (µg/kg) scale. Experimental parameters vary depending on the pathways and systems under investigation.
Observed findings suggest that melanocortin-related peptides may influence molecular pathways involved in cellular communication and pigment-related biological processes. These findings remain under investigation and should not be interpreted as evidence of clinical outcomes.
Melanotan 2 (MT2) (10mg) Handling & Storage
- Melanotan 2 (MT2) (10mg) Handling & Storage
- Store lyophilized powder at 2–8 °C or –20 °C in a controlled environment, protected from light, heat, and moisture.
- After reconstitution with sterile laboratory-grade solvent, store the solution at 2–8 °C.
- Avoid repeated freeze-thaw cycles. Use aseptic technique and follow institutional biosafety guidelines.
Compliance Notice: This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in-vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.
References
- García-Borrón JC, Abdel-Malek Z, Jiménez-Cervantes C. MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation. Pigment Cell Melanoma Res. 2014;27(5):699-720. doi:10.1111/pcmr.12257
- Wolf Horrell EM, Boulanger MC, D'Orazio JA. Melanocortin 1 Receptor: Structure, Function, and Regulation. Front Genet. 2016;7:95. Published 2016 May 31. doi:10.3389/fgene.2016.00095
- Swope VB, Abdel-Malek ZA. MC1R: Front and Center in the Bright Side of Dark Eumelanin and DNA Repair. Int J Mol Sci. 2018;19(9):2667. Published 2018 Sep 8. doi:10.3390/ijms19092667
- Singh M, Mukhopadhyay K. Alpha-melanocyte stimulating hormone: an emerging anti-inflammatory antimicrobial peptide. Biomed Res Int. 2014;2014:874610. doi:10.1155/2014/874610