KPV is a synthetic tripeptide derived from the C-terminal region of alpha-melanocyte-stimulating hormone (α-MSH). It consists of three amino acids—lysine, proline, and valine—and has a molecular weight of approximately 371.5 g/mol.
KPV (10mg) is supplied as a high-purity lyophilized powder in a sterile vial, suitable for controlled laboratory applications. This compound has been examined in research on cellular signaling and immune-related mechanisms, particularly in studies of inflammatory signaling.
KPV (10mg) Key Features & Specs
- Subcategory: Healing & Regenerative Peptides
- Strength: 10mg per vial
- CAS: 112965-21-6
- Chemical Formula: C₁₆H₃₀N₄O₄
- Molecular Weight:43 g/mol
- Peptide Sequence: Lys-Pro-Val
- Synonyms: Lysine Proline Valine
For laboratory research use only.
KPV (10mg) Research Uses
KPV research has focused on the peptide’s role in immune signaling and the regulation of the inflammatory response. It has been examined for interactions with cytokine activity and communication among immune cells under controlled conditions.
Additionally, KPV research has explored its relevance in epithelial systems, including models of the skin and gastrointestinal tract. Ongoing studies are investigating how this peptide may affect cellular responses under inflammatory conditions and contribute to broader signaling investigations.
KPV (10mg) Insights & Observed Findings
Preclinical and in-vitro studies of KPV have evaluated various concentrations depending on the experimental design. Findings suggest interactions with markers associated with inflammatory signaling pathways.
KPV peptide has been used in controlled research settings to assess both localized and systemic responses. These observations are limited to experimental contexts and aim to support further investigations into peptide-driven biological processes.
KPV (10mg) Handling & Storage
Store the lyophilized peptide at –20°C in a controlled environment. Store protected from light and moisture.
After reconstitution, the solution should be kept refrigerated and handled using proper sterile laboratory techniques. Minimize freeze-thaw cycles during handling to maintain consistency in research applications.
Compliance Notice: This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in-vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.
References
- Sung J, Ju SY, Park S, Jung WK, Je JY, Lee SJ. Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway. Tissue Cell. 2025;95:102837. doi:10.1016/j.tice.2025.102837
- Xiao B, Xu Z, Viennois E, et al. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Mol Ther. 2017;25(7):1628-1640. doi:10.1016/j.ymthe.2016.11.020
- Land SC. Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists. Int J Physiol Pathophysiol Pharmacol. 2012;4(2):59-73.
- Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166-178. doi:10.1053/j.gastro.2007.10.026
- Hiltz ME, Lipton JM. Antiinflammatory activity of a COOH-terminal fragment of the neuropeptide alpha-MSH. FASEB J. 1989;3(11):2282-2284.