Kisspeptin (5mg) is a synthetic decapeptide derived from the kisspeptin protein family. It corresponds to the biologically active fragment known as Metastin (45–54), or KP-10. Composed of 10 amino acids, Kisspeptin has been studied in laboratory settings for its role in endocrine signaling pathways.

This peptide is involved in regulatory processes within the hypothalamic–pituitary axis and is commonly investigated in research on hormone signaling and communication within the reproductive system.

Research-grade Kisspeptin is typically produced with high purity and verified by HPLC and mass spectrometry. It is supplied as a 5 mg lyophilized powder in a sealed, research-grade vial, intended for controlled laboratory use in studies of endocrine signaling, neuroendocrine communication, and hormone-regulation pathways.

Kisspeptin (5mg) Key Features & Specs

• Subcategory: Hormonal & Endocrine Research Peptides
• Strength: 5 mg
• CAS Number: 374675-21-5
• Chemical Formula: C₆₃H₈₃N₁₇O₁₄
• Molecular Weight:4 g/mol
• Peptide Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
• Synonyms: Metastin (45–54), KP-10

For laboratory research use only.

Kisspeptin (5mg) Research Uses

Kisspeptin (5mg) is studied in laboratory environments focusing on endocrine signaling and reproductive hormone regulation. As a key signaling molecule within the hypothalamic system, it is often used in research examining communication pathways that regulate hormone release.

Studies commonly explore biological systems related to neuroendocrine signaling, regulation of the reproductive system, and cellular communication between central and peripheral endocrine structures. These investigations aim to better understand how peptide signaling influences hormonal coordination and feedback mechanisms.

In experimental models, Kisspeptin is used to study how signaling molecules affect cellular pathways involved in hormone regulation and endocrine system communication.

Kisspeptin (5mg) Insights & Observed Findings

Preclinical and in vitro studies have evaluated Kisspeptin activity in the nanomolar range, depending on the experimental design and biological system. These studies are typically focused on examining hormone signaling dynamics and cellular responses.

Animal studies involving neuroendocrine peptides have reported dosing in the microgram-per-kilogram (µg/kg) range. Experimental conditions may vary depending on the pathways being studied and the model used.

Preliminary findings suggest that Kisspeptin-related signaling may influence molecular pathways involved in reproductive hormone regulation and endocrine communication. These observations are still under investigation and should not be interpreted as evidence of clinical outcomes.

Kisspeptin (5mg) Handling & Storage

Kisspeptin (5mg) should be stored under controlled laboratory conditions to maintain its integrity.

• Store the lyophilized powder at 2–8 °C.
• Protect the powder from light, heat, and moisture.
• After reconstitution with sterile laboratory-grade solvent, the solution should be stored at 2–8 °C and handled according to standard laboratory procedures.
• Avoid repeated freeze–thaw cycles, as they may compromise the peptide's stability.
• Appropriate protective laboratory equipment should be used during handling.
• Follow institutional biosafety guidelines for disposal.

Compliance Notice: This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in-vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.

References

1. Kotani M, Detheux M, Vandenbogaerde A, et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem. 2001;276(37):34631-34636. doi:10.1074/jbc.M104847200
2. Oakley AE, Clifton DK, Steiner RA. Kisspeptin signaling in the brain. Endocr Rev. 2009;30(6):713-743. doi:10.1210/er.2009-0005
3. Sliwowska JH, Woods NE, Alzahrani AR, Paspali E, Tate RJ, Ferro VA. Kisspeptin a potential therapeutic target in treatment of both metabolic and reproductive dysfunction. J Diabetes. 2024;16(4):e13541. doi:10.1111/1753-0407.13541
4. Mills EGA, Dhillo WS, Comninos AN. Kisspeptin and the control of emotions, mood and reproductive behaviour. Journal of Endocrinology. 2018;239(1):R1-R12. doi:10.1530/joe-18-0269