GHK-Cu (100 mg) is a synthetic copper-binding tripeptide composed of the Gly-His-Lys complexed with a copper ion (Cu²⁺). It is produced using controlled peptide synthesis and complexation methods to achieve research-grade purity suitable for laboratory investigation.
In research settings, the copper peptide GHK-Cu is typically supplied as a lyophilized powder in a sterile vial, enabling precise preparation under defined experimental protocol conditions. Current research has explored its interactions with biological systems involved in cellular signaling, protein regulation, and tissue processes. It is commonly studied in models that examine how copper-binding peptides influence cellular communication-related processes and structural response-related outcomes.
GHK-Cu (100mg) Key Features & Specs
- Subcategory: Healing & Regenerative Peptides
- Strength: 100 mg
- CAS: 89030-95-5
- Chemical Formula: C₁₄H₂₁N₆O₄Cu
- Molecular Weight: 401.91 g/mol
- Peptide Sequence: Gly-His-Lys(Cu²⁺)
- Synonyms: Copper peptide, GHK, Tripeptide, GHK-Cu acetate, Gly-His-Lys-Cu(II)
The copper peptide GHK-Cu is supplied as a lyophilized compound intended for laboratory preparation and experimental study. The material is packaged in a research vial suitable for controlled laboratory environments where consistent peptide quality is required.
For laboratory research use only.
GHK-Cu (100mg) Research Uses
In laboratory investigations, the peptide has been studied for its interactions with cellular processes and molecular signaling pathways involved in tissue maintenance. Many research models examine how small copper-binding peptides modulate biological pathways involved in cellular repair and regeneration.
These studies frequently focus on cell culture environments or preclinical research models to examine biological response readouts. The copper peptide GHK-Cu is also being investigated for its potential role in cellular signaling pathways that influence skin-biology-related processes, connective-tissue-related function, and other processes involved in tissue-structure-related and maintenance-related mechanisms.
GHK-Cu (100mg) Insights & Observed Findings
Scientific investigations have examined the peptide's behavior under controlled laboratory conditions. Studies involving the copper peptide GHK-Cu often evaluate its interactions with cultured cells and biological models used to observe cellular signaling responses.
Published reports frequently report experimental concentrations used in laboratory settings to study cellular behavior. Researchers may monitor changes in gene activity, cellular communication patterns, or molecular markers associated with tissue-related biological processes.
Additional experimental research has examined how copper-binding peptides modulate biological-response-related readouts in cell-based models. These investigations aim to improve understanding of peptide-driven signaling mechanisms in controlled research settings.
GHK-Cu (100mg) Handling & Storage
- Store GHK-Cu (100mg) at –20 °C or below in the original sealed vial.
- Protect the vial from light, moisture, and heat before use.
- Allow the vial to reach room temperature prior to opening to minimize condensation inside the container.
- Reconstitute the peptide in sterile, particle-free aqueous buffer using appropriate aseptic techniques.
- After reconstitution, store the solution under refrigeration at 2–8 °C for use in the same experimental session or as specified by the investigator, and protect from light.
- Dispose of unused material according to institutional laboratory safety procedures and regulatory guidelines for research chemicals.
Compliance Notice: This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in-vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.
References
- Glycyl-L-histidyl-L-lysine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/73587
- Maquart FX, Pickart L, Laurent M, Gillery P, Monboisse JC, Borel JP. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide‐copper complex glycyl‐L‐histidyl‐L‐lysine‐Cu2+. FEBS Letters. 1988;238(2):343-346. doi:10.1016/0014-5793(88)80509-x
- Maquart FX, Bellon G, Chaqour B, et al. In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds. Journal of Clinical Investigation. 1993;92(5):2368-2376. doi:10.1172/jci116842
- Pickart L, Vasquez-Soltero JM, Margolina A. The Human Tripeptide GHK-CU in Prevention of Oxidative Stress and Degenerative Conditions of aging: Implications for Cognitive Health. Oxidative Medicine and Cellular Longevity. 2012;2012:1-8. doi:10.1155/2012/324832
- Pickart L, Margolina A. Regenerative and protective actions of the GHK-CU peptide in the light of the new gene data. International Journal of Molecular Sciences. 2018;19(7):1987. doi:10.3390/ijms19071987
- Pickart L, Vasquez-Soltero J, Margolina A. The effect of the human peptide GHK on gene expression relevant to nervous system function and cognitive decline. Brain Sciences. 2017;7(2):20. doi:10.3390/brainsci7020020