Epithalon (50 mg) is a synthetic tetrapeptide composed of four amino acids. The compound is commonly referred to as the Epithalon tetrapeptide, reflecting its four-residue sequence derived from research into naturally occurring regulatory peptides.

In laboratory environments, Epithalon peptide has been studied for its interactions with components of cellular processes related to aging, cellular regulation, and metabolic activity.

Epithalon (50mg) Key Features & Specs

• Subcategory: Longevity & Anti-Aging Peptides
• Strength: 50 mg
• CAS: 307297-39-8
• Chemical Formula: C₁₄H₂₂N₄O₉
• Molecular Weight: 390.34 g/mol
• Peptide Sequence: Ala-Glu-Asp-Gly
• Synonyms: Epitalon, Epithalone, Epithalamin

For laboratory research use only.

Epithalon (50mg) Research Uses

Epithalon has been studied in experimental systems related to aging-related processes, circadian biology, and cellular signaling. Researchers studying the peptide often examine how it interacts with cellular pathways related to aging and metabolic balance.

Studies exploring the Epithalon peptide frequently focus on cellular-maintenance-related systems, gene-expression-related patterns, and molecular-activity-related readouts associated with tissue function.

These studies aim to better understand how regulatory peptides may influence fundamental cellular processes in aging-related and physiological-regulatory-related models.

Epithalon (50mg) Insights & Observed Findings

Certain preclinical studies on Epithalon have evaluated its interactions with cellular-aging-marker-related endpoints, metabolic-signaling-related pathways, and regulatory-related mechanisms in cultured cells. Researchers typically analyze changes in cellular-behavioral readouts, gene-expression patterns, or molecular-activity endpoints following exposure to the peptide.

Epithalon (50mg) Handling & Storage

• Epithalon (50 mg) should be handled using standard laboratory procedures appropriate for peptide compounds. The lyophilized material is typically stored at low temperatures to help maintain structural integrity before use.
• Recommended handling practices include storing the vial at –20 °C or below in a dry environment protected from direct light and moisture.
• Allow the vial to reach room temperature prior to opening to help prevent condensation inside the container.
• If reconstituted for experimental use, solutions should be prepared using sterile laboratory techniques and stored under refrigerated conditions for use in the same experimental session or as specified by the investigator, and protected from light.
• Any remaining material should be handled and disposed of according to institutional laboratory safety procedures and regulatory guidelines for research chemicals.

Compliance Notice: This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in-vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.

References

1. Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł. Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025;26(6):2691. Published 2025 Mar 17. doi:10.3390/ijms26062691
2. Khavinson V, Diomede F, Mironova E, et al. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. 2020;25(3):609. Published 2020 Jan 30. doi:10.3390/molecules25030609
3. Caputi S, Trubiani O, Sinjari B, et al. Effect of short peptides on neuronal differentiation of stem cells. Int J Immunopathol Pharmacol. 2019;33:2058738419828613. doi:10.1177/2058738419828613
4. Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592. doi:10.1023/a:1025493705728
5. Anisimov VN, Khavinson VKh, Popovich IG, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202. doi:10.1023/a:1025114230714