KPV is a small tripeptide derived from the C-terminal segment of alpha-melanocyte-stimulating hormone (α-MSH). It consists of lysine, proline, and valine, with a molecular weight of approximately 371.5 g/mol. Due to its small size and structural simplicity, KPV is commonly used in controlled laboratory settings to study peptide-receptor interactions and related signaling pathways.
KPV (5mg) is typically provided as a high-purity, lyophilized powder in a sterile vial, facilitating precise handling and preparation in research environments. It has been examined for its potential role in immune modulation and cellular responses, particularly in studies of inflammatory signaling pathways.
KPV (5mg) Key Features & Specs
KPV (5mg) is often used in research settings focused on peptide-related investigations. Its defined structure and stability make it a valuable tool for studying peptide behavior, cellular signaling, and the development of experimental assays.
- Subcategory: Healing & Regenerative Peptides
- Strength: 5mg per vial
- CAS: 112965-21-6
- Chemical Formula: C₁₆H₃₀N₄O₄
- Molecular Weight: 342.43 g/mol
- Peptide Sequence: Lys-Pro-Val
- Synonyms: Lysine Proline Valine
For laboratory research use only.
KPV (5mg) Research Uses
Research on KPV has primarily focused on its role in immune signaling and modulation of the inflammatory response. It has been studied for its potential effects on cytokine activity and cellular communication in immune-related environments.
Additionally, KPV has been explored for its interactions in epithelial tissues, including in models of the skin and gastrointestinal tract. Studies have examined the peptide's potential impact on cellular responses under inflammatory conditions and its broader role in maintaining balance in signaling pathways.
KPV (5mg) Insights & Observed Findings
In experimental models, KPV’s anti-inflammatory activity has been assessed at various concentrations depending on the study design. Observations from in-vitro and preclinical research suggest measurable effects on markers associated with inflammatory signaling pathways.
KPV has also been used in controlled environments to assess both localized and systemic responses under different exposure conditions. These findings are limited to research settings and contribute to the understanding of peptide-related biological activity.
KPV (5mg) Handling & Storage
Store KPV (5mg) in a freezer at –20°C in a dry, controlled environment. Store protected from light and moisture.
After reconstitution, the solution should be stored under refrigerated conditions and handled using proper sterile laboratory techniques. Minimize freeze-thaw cycles during handling to maintain research integrity.
Compliance Notice: This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in-vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.
References
- Sung J, Ju SY, Park S, Jung WK, Je JY, Lee SJ. Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway. Tissue Cell. 2025;95:102837. doi:10.1016/j.tice.2025.102837
- Xiao B, Xu Z, Viennois E, et al. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Mol Ther. 2017;25(7):1628-1640. doi:10.1016/j.ymthe.2016.11.020
- Land SC. Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists. Int J Physiol Pathophysiol Pharmacol. 2012;4(2):59-73.
- Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166-178. doi:10.1053/j.gastro.2007.10.026
- Hiltz ME, Lipton JM. Antiinflammatory activity of a COOH-terminal fragment of the neuropeptide alpha-MSH. FASEB J. 1989;3(11):2282-2284.