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BOTULAX® 100u (Korean)


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Brand:

BOTULAX®

Manufacturer:

Hugel Pharma

Active Substance(s):

BOTULINUM TOXIN TYPE A

Strength:

100u

Pack size:

1 x 100u Vial (Powder)

About the product

BOTULAX® is a peripheral muscle relaxant that contains purified botulinum toxin type A (in combination with haemagglutinin) and sodium chloride (excipient). The mechanism of action of the product is based on the ability of botulinum toxin type A to block the transmission of nerve impulses. Intramuscular administration of the toxin disrupts the synthesis of acetylcholine (a neurotransmitter that ensures neuromuscular conduction) and leads to temporary paralysis of the facial muscles. Frozen facial expressions help relax muscles and smooth wrinkles. Anti-wrinkle treatment to be used for nasolabial folds, hyperhidrosis, lip contouring, and overall natural face lifting.

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For blepharospasm, reconstituted BOTULAX® 100 (see Dilution Table) is injected using a sterile, 27-30 gauge needle without electromyographic guidance. The initial recommended dose is 1.25-2.5U (0.05ml to 0.1 ml volume at each site) injected into the medial and lateral pre-tarsal orbicularis oculi of the upper lid and into the lateral pre-tarsal orbicularis oculi of the lower lid. In general, the initial effect of the injections is seen within three days and reaches a peak at one to two weeks post-treatment. Each treatment lasts approximately three months, following which the procedure can be repeated.

At repeat treatment sessions, the dose may be increased up to two-fold if the response from the initial treatment is considered insufficient-usually defined as an effect that does not last longer than two months. However, there appears to be little benefit obtainable from injecting more than 5.0U per site. Some tolerance may be found when the drug is used in treating blepharospasm if treatments are given any more frequently than every three months, and it is rare to have the effect be permanent. The cumulative dose of BOTULAX® 100 treatment in a 30-day period should not exceed 200U.

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