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Between Xeomin or Botox, Which Lasts Longer?

David Fuller

Last Updated On: June 18, 2024

Recent statistics by the American Society for Aesthetic Plastic Surgery revealed that injectable neurotoxins were the most popular minimally-invasive cosmetic procedure in 2022.  Among these injectables, Xeomin and Botox are two leading options for reducing wrinkles and fine lines.  

Both work by temporarily relaxing facial muscles, but some patients wonder if one lasts longer than the other. Xeomin is a purified form of Botox but without specific proteins.  This difference may influence how long the effects last and how a person’s body reacts to the treatment.

In this article, we’ll explore the key characteristics of both Xeomin and Botox, comparing their formulations, how they work within the body, and the typical duration of their effects.

Key Takeaways

  • Xeomin and Botox are both popular botulinum toxin type A treatments used for cosmetic procedures.
  • Understanding the formulations, mechanisms of action, and clinical efficacy of Xeomin and Botox is essential for making informed treatment decisions.
  • Clinical studies, real-world case examples, and expert opinions provide valuable insights into the comparative efficacy, safety, and longevity of Xeomin and Botox.
  • Practitioners and patients should consider treatment preferences, patient satisfaction, and cost-effectiveness when choosing between Xeomin and Botox.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to buy Xeomin online, contact our sales department for more information.

Understanding Xeomin and Botox

Xeomin and Botox are botulinum toxin treatments to smooth wrinkles by relaxing facial muscles. Produced by Merz Aesthetics, their injection is unique due to Xeomin’s molecule, which is called naked since it lacks the additional proteins found in other brands. This purity may reduce the risk of treatment resistance, ensuring effectiveness over time.

Doctors often prefer Xeomin for its purity and rapid onset of action, which is sometimes noticeable within a day. Like Botox, its effects typically last three to four months, with some patients experiencing results for up to six months or more.

Botox, derived from the bacterium Clostridium botulinum, is also used to smooth lines and treat medical conditions like cervical dystonia. While its effects take 3 to 5 days to appear, they generally last three to four months, offering patients both aesthetic improvements and relief from certain medical conditions.

Formulations and Mechanisms of Action

Xeomin and Botox work by relaxing muscles to smooth wrinkles, but they are made differently to achieve similar results. Xeomin is produced in a way that maintains its purity, containing only botulinum toxin type A without additional proteins. This process reduces the risk of the body developing resistance to the treatment over time.

Doctors use Xeomin to treat various conditions, including cervical dystonia and frown lines, as it tends to have fewer side effects due to its purity. Its fast-acting nature means patients may see results in as little as one day, with effects lasting up to six months.

On the other hand, Botox contains a purified form of botulinum toxin A, along with other stabilizing proteins. It works by blocking nerve signals to relax muscles and is used to smooth wrinkles, treat muscle spasms, and address health issues. Results typically last three to four months, with variations in how quickly they appear and how long they endure between individuals.

Mechanisms of Action

Xeomin blocks signals from nerves to muscles, preventing muscle contraction and smoothing facial wrinkles and lines. Its pure form of botulinum toxin, without added proteins, reduces the risk of adverse reactions. Effective for both cosmetic and medical purposes, Xeomin targets muscle activity directly, making it suitable for conditions like cervical dystonia. 

Unlike Botox, Xeomin’s purity decreases the likelihood of developing antibodies that could reduce treatment effectiveness over time. Botox works similarly, smoothing wrinkles and relaxing muscles. 

Results typically appear within 3-5 days and last three to four months before muscle activity resumes, necessitating further treatment for continued smooth skin.

Clinical Efficacy and Longevity

Comparative analysis of clinical studies suggests intriguing insights into the efficacy and longevity of Xeomin and Botox treatments. A closer look reveals nuances in clinical outcomes, patient satisfaction, and duration of effects. This comparison, grounded in factual data, offers medical professionals a clearer understanding of these treatments.

Study CharacteristicsXeominBotox
Onset of ActionAs early as one dayUsually takes 3-5 days
Duration of EffectsUp to six months, typically 3-4 monthsThree to four months, with possibilities up to 4-5 months
Clinical EfficacyAccording to a study of 180 people, it works faster and lasts longer than Botox based on a six-month assessmentEffects lasting up to four to five months or longer in some individuals
Individual VariabilityLonger-lasting effects reported, though, vary by individualDuration depends on factors like individual response, muscle activity

Real-World Case Examples and Expert Opinions

Through real-life stories from doctors and patients, we gain valuable insights into the effectiveness and duration of Xeomin and Botox treatments. These experiences help us understand which treatment may work better and provide longer-lasting results for different individuals, guiding informed decisions about cosmetic interventions.

Case Example of Xeomin Treatments

Image courtesy of Avanti Medical Center

This patient was bothered by the prominent wrinkles on her forehead and between her brows. Seeking a solution, she opted for Xeomin neurotoxin injections. A total of 36 units were administered, with 20 units placed across her forehead and the remaining 16 units between her brows. The treatment significantly reduced the wrinkles, giving her a smooth, “wave-less” forehead.

Case Example of Botox Treatments

Image courtesy of United Plastic Surgery

Gia was concerned about the appearance of frown lines on her forehead but still wanted to maintain her natural look. Opting for Botox cosmetics, she found a solution that allowed her to reduce the appearance of these lines while still looking like herself. Botox cosmetic injections effectively improved the look of Gia’s moderate to severe forehead lines and frown lines between her eyebrows. 


For some people, Xeomin might last a bit longer than Botox. Studies show that Xeomin’s effects can start quickly and last six months. Yet, Botox usually works well for three to four months. Everyone reacts differently, so the best choice depends on what you need and your doctor’s advice. Talking to a healthcare professional can help you pick the right one.


1. What’s the difference between Xeomin and Botox?

Xeomin and Botox, both FDA-approved for smoothing frown lines, have unique features. Unlike Botox, Xeomin is a pure form of the molecule used in these treatments, without additional additives.

2. How long does it take for Xeomin to show its effects?

After a Xeomin treatment, you may quickly notice results, usually within a week. If you’re looking for rapid changes, watch around that time.

3. Which lasts longer – Xeomin or Botox?

While both treatments can last a considerable amount of time, the duration can vary depending on the individual and the treatment area. Generally, many patients find that both Xeomin and Botox offer similar lasting effects.

4. Can I use Xeomin for other issues besides frown lines?

Absolutely! In addition to treating forehead wrinkles, doctors use Xeomin for conditions such as cervical dystonia and to relax muscles in the jaw, such as with masseter muscle concerns. Xeomin is known for its versatility in addressing various cosmetic and medical issues.


American Society of Plastic Surgeons. The American Society of Plastic Surgeons ® Procedural Statistics Data Insights Partners: 2022 ASPS Procedural Statistics Release.; 2023. https://www.plasticsurgery.org/documents/News/Statistics/2022/plastic-surgery-statistics-report-2022.pdf 

Botox: Side effects, function, uses, procedure, and more. www.medicalnewstoday.com. https://www.medicalnewstoday.com/articles/158647



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