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Ozempic Long-Term Side Effects – What Are They?

David Fuller

Last Updated On: July 5, 2024

According to a recent study, side effects associated with diabetes type 2 medications can significantly impact patients’ quality of life. These medications aim to manage blood sugar levels, but they often come with a range of adverse effects.

One commonly prescribed medication for type 2 diabetes is Ozempic (semaglutide). While effective in controlling blood sugar, Ozempic can cause various side effects. Fortunately, these side effects are manageable through lifestyle adjustments and over-the-counter remedies.

In this article, we will explore the long-term effects of Ozempic, delve into serious side effects, and provide practical tips for managing them.

Key Takeaways

  • Ozempic is a medication used to manage type 2 diabetes and aid in weight loss.
  • Common long-term side effects of Ozempic include gastrointestinal issues, injection site reactions, and hypoglycemia.
  • Severe but rare long-term side effects may include pancreatitis, thyroid tumors, and kidney problems.
  • Clinical trial data and patient case studies provide insights into the long-term safety profile of Ozempic.
  • Healthcare providers should monitor patients using Ozempic and educate them on managing potential long-term side effects.

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What is Ozempic?

Ozempic, featuring semaglutide as its active ingredient, is tailored for managing type 2 diabetes by mimicking a blood sugar-regulating hormone. Doctors often prescribe it to enhance blood sugar control in adults, complementing diet and exercise. Its once-weekly injection schedule is convenient, contrasting daily options. 

Beyond diabetes, Ozempic intrigues for potentially aiding weight loss, which is particularly beneficial for conditions like PCOS. In such cases, healthcare providers explore its off-label use, emphasizing safe usage amid its approved and emerging benefits. Ozempic also shows promise in heart health, safeguarding against risks in those with or prone to heart disease.

Common Long-Term Side Effects of Ozempic

Ozempic can cause some side effects that stick around for a while. These include stomach issues, reactions where the shot was given, and low blood sugar.

  • Gastrointestinal Issues: Due to Ozempic’s effects on digestion, gastrointestinal problems, including stomach pain, nausea, vomiting, diarrhea, and constipation, are common when starting Ozempic. Symptoms often improve over time, and managing them involves eating smaller meals and avoiding fatty foods.
  • Injection Site Reactions: Redness, swelling, and pain at the injection site are typical side effects of Ozempic. These reactions usually resolve on their own but can be bothersome. Rotating injection sites and keeping them clean can help alleviate discomfort.
  • Hypoglycemia: Ozempic users, especially when combined with other diabetes medications or insufficient food intake, may experience low blood sugar (hypoglycemia). Symptoms include shakiness, dizziness, and hunger. Immediate treatment with fast-acting sugars like juice or glucose tablets is crucial. Monitoring diet closely and discussing medication management with healthcare providers can help prevent hypoglycemia.

Rare but Serious Long-Term Side Effects of Ozempic

While Ozempic helps many, it can also cause significant health problems. Some people get sick with pancreatitis or thyroid tumors.

  • Pancreatitis: Pancreatitis, an inflammation of the pancreas, is a rare but serious side effect of Ozempic. Symptoms include severe abdominal pain, nausea, and vomiting. If you experience sudden, persistent stomach pain, contact your doctor immediately. Early detection and treatment are crucial to prevent severe complications related to pancreatitis.
  • Thyroid Tumors: Ozempic may increase the risk of medullary thyroid carcinoma (MTC), a type of thyroid cancer. Patients should watch for symptoms like neck lumps, swelling, difficulty swallowing and breathing. Regular check-ups are essential for early detection. While MTC is uncommon, awareness and monitoring are vital for Ozempic users.
  • Kidney Problems: Ozempic can potentially lead to kidney issues, especially in those with pre-existing conditions. It stresses the kidneys by affecting blood sugar levels. Patients should be monitored for signs such as changes in urine output or leg and foot swelling. Regular check-ups and vigilance are vital to detect and manage kidney problems early.

Clinical Trial Data on Long-Term Side Effects

Clinical trial data give us insights into Ozempic’s long-term safety, comparing it with other diabetes medications. Feel curious? Keep reading to learn more about what the research says.

One study evaluated semaglutide use in more than 17,000 patients with preexisting heart disease. It found that semaglutide (the active ingredient in Ozempic and Wegovy) reduced the risk of serious cardiovascular issues (heart attack, stroke, and death) by 20%.

Another research shows that semaglutide can improve blood sugar control and control obesity for up to three years. These studies highlight the benefits of semaglutide for weight loss and overall health.

Comparison with Other Diabetes Medications

A comparison of Ozempic vs Wegovy or other similar treatments highlights significant aspects of their long-term safety profile and effectiveness. Below is a summarized presentation comparing Ozempic to other prevalent diabetes treatments:

MedicationCommon Long-Term Side EffectsRare but Serious Side EffectsEffectiveness in Lowering A1C
Semaglutide (Ozempic and Wegovy)Gastrointestinal issues, injection site reactions, hypoglycemiaPancreatitis, thyroid tumors, kidney problemsSignificantly reduces A1C and weight
MetforminGastrointestinal issues, vitamin B12 deficiencyLactic acidosisReduces A1C moderately
Sulfonylureas (e.g., Glipizide)Weight gain, hypoglycemiaCardiovascular events (in certain patients)Reduces A1C moderately
Insulins (e.g., Lantus)Hypoglycemia, weight gainHypokalemiaSignificantly reduces A1C
DPP-4 Inhibitors (e.g., Januvia)Upper respiratory tract infection, headachePancreatitis, severe joint painReduces A1C modestly

Patient Case Studies on Long-Term Side Effects

Ozempic has become a notable medication in managing diabetes and weight loss. Many patients share their stories about using Ozempic, offering insights into its long-term side effects.

Image courtesy of Parade

“At the time, being in my late 20s, I felt as if I should have been aging into my 50s to 60s. That is now completely gone. My PCOS symptoms have gotten a lot better, too. My cycle is more on track. My adult acne has gone down, and my excess facial hair is subsiding. It’s incredible.”

Image courtesy of Today

“It makes food less important… I have really thought about this in terms of health a lot. I’m older. I don’t think I can afford to (mess) around with weight anymore.”

Monitoring and Managing Long-term Side Effects

Healthcare providers play a crucial role in monitoring and managing the long-term side effects of Ozempic. Focusing on patient safety, these guidelines can help you effectively oversee treatment with this medication.

  • Stay Informed: Keep up-to-date with the latest research on Ozempic’s long-term side effects to make informed patient care decisions.
  • Patient Education: Inform patients about potential gastrointestinal issues, injection site reactions, and hypoglycemia, and encourage them to report symptoms immediately.
  • Individualized Treatment Plans: Before recommending Ozempic, evaluate each patient’s medical history, considering risks like pancreatitis, thyroid tumors, and kidney problems.
  • Monitor Closely: Regularly check for signs of pancreatitis, monitor thyroid function, and evaluate kidney health to detect problems early.
  • Compare Medications: Understand Ozempic’s safety profile compared to other diabetes medications to guide treatment decisions.
  • Real-Life Evidence: Review case studies of long-term Ozempic users for insights on managing side effects and improving quality of life.
  • Follow-Up Care: Schedule regular follow-up appointments to monitor responses to Ozempic and adjust treatment as needed.
  • Report Side Effects: Encourage patients to report adverse reactions and submit them to health authorities to enhance their knowledge of drug safety.


Ozempic has long-term side effects, including stomach issues, injection site reactions, pancreatitis, thyroid tumors, and kidney problems. Monitoring symptoms and working closely with a doctor are crucial for managing these risks while benefiting from the medication. Staying informed ensures safe use over time.


1. What are the long-term side effects of Ozempic? 

Ozempic may have potential long-term side effects, which vary among individuals. If you have any persistent issues, it is crucial to consult your doctor.

2. How does Ozempic compare to Saxenda?

Ozempic and Saxenda serve similar purposes but may differ in side effects. Consult a healthcare professional before deciding on a treatment plan.

3. Are there any noticeable changes with Ozempic before and after use? 

Yes, individuals using Ozempic report visible changes over time. However, responses to the medication can vary widely among individuals.

4. Does refrigeration affect the effectiveness of Ozempic? 

Yes, proper refrigeration is essential to maintain the potency of Ozempic. Improper storage can reduce efficacy and increase the risk of adverse reactions.


Ozempic Side Effects: Common, Severe, Long Term. Drugs.com. https://www.drugs.com/sfx/ozempic-side-effects.html 

Semaglutide (Subcutaneous Route) Side Effects – Mayo Clinic. www.mayoclinic.org. https://www.mayoclinic.org/drugs-supplements/semaglutide-subcutaneous-route/side-effects/drg-20406730?p=1 



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