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Ozempic Wegovy – Comparing Weight Loss Treatments

David Fuller

Last Updated On: July 5, 2024

Obesity affects approximately 42% of adults in the United States, according to the Centers for Disease Control and Prevention (CDC). Despite efforts, many individuals struggle to lose weight through willpower alone. With the rising prevalence of obesity, there is an increasing demand for effective weight loss treatments that can help individuals manage their weight and improve overall health.

Two prominent medications in the fight against obesity are Ozempic and Wegovy. Both treatments utilize semaglutide, a GLP-1 receptor agonist, to aid in weight loss by regulating appetite and enhancing metabolic processes. Ozempic, initially developed for managing type 2 diabetes, has shown significant weight loss benefits, while Wegovy is specifically approved for chronic weight management.

This article will delve into their mechanisms of action, dosing schedules, potential side effects, and real-world patient experiences.

Key Takeaways

  • Ozempic and Wegovy contain the active ingredient semaglutide but are used for different indications.
  • The mechanisms of action of Ozempic and Wegovy focus on appetite and metabolism regulation.
  • Clinical trials have shown significant weight loss results with both medications.
  • Both medications have common and serious side effects that need to be considered.
  • Dosing schedules, patient selection criteria, and cost are important practical considerations for medical professionals.

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Understanding Ozempic and Wegovy

Ozempic is a prescription medicine primarily for managing type 2 diabetes and aiding weight loss in adults with obesity or weight-related health issues. Because semiglutide is one of Ozempic’s ingredients, this treatment can help control blood sugar, reduce cardiovascular risks, and support weight loss. Proper dosing and refrigeration are crucial for its effectiveness. Ozempic shows promising results in both blood sugar control and significant weight loss.

Wegovy, also containing semaglutide, is prescribed for obesity or overweight issues, including related health problems like high blood pressure, type 2 diabetes, or high cholesterol. As a weekly injection, Wegovy effectively aids weight loss and health improvement alongside diet and exercise.

Mechanism of Action

Ozempic and Wegovy mimic the GLP-1 hormone to regulate blood sugar and digestion, aiding weight loss. Ozempic slows stomach emptying, prolonging fullness and reducing food intake. It targets appetite-controlling brain areas, diminishing hunger cues and aiding calorie reduction.

Similarly, Wegovy controls hunger by slowing stomach emptying and affecting hunger signals in the brain, promoting smaller portions and easier weight management. Both medications are effective for weight and blood sugar control, offering valuable options for patients looking to enhance their health, especially those with conditions like PCOS.

Clinical Efficacy

Ozempic and Wegovy, both GLP-1 mimickers, effectively promote weight loss and improve blood sugar levels. They prolong fullness, reduce appetite, and help manage weight. Users often report significant weight reduction and better health outcomes, making these medications valuable for individuals struggling with obesity and related conditions like PCOS.

Image courtesy of Accepting Therapy

Exploring the clinical efficacy of Ozempic and Wegovy reveals a detailed landscape of their impacts on weight loss. The trials vividly show how these treatments stack up against each other. Here’s a compact table summarizing the weight loss results from pivotal clinical trials of both drugs:

Image courtesy of The L.A. Glow

TreatmentKey TrialAverage Weight LossStudy DurationParticipant Number
OzempicSUSTAIN-6Approx. 4.9% of baseline body weight104 weeks3,297 (Type 2 diabetes patients)
WegovySTEP 1Approx. 15% of baseline body weight68 weeks1,961 (Obese or overweight adults without diabetes)

This summary underscores the nuanced differences and similarities Ozempic and Wegovy exhibit in clinical settings. 

Safety Profiles

Safety is vital when using Ozempic or Wegovy. Each has its own set of standards and serious side effects to watch out for. Here are the most common ones:

  • Nausea: Many people feel sick to their stomach after taking Ozempic.
  • Vomiting: Along with nausea, some might throw up.
  • Diarrhea: Ozempic can upset your stomach, leading to diarrhea.
  • Stomach Pain: Some users report pain or discomfort in the abdomen.
  • Constipation: While some experience loose stools, others might struggle to have a bowel movement.
  • Headache: A common side effect, headaches can occur.
  • Fatigue: Feeling unusually tired is another side effect of Ozempic.
  • Dizziness: Some patients may feel dizzy after taking their dose.
  • Reduced Appetite: Ozempic can make you feel less hungry, which helps with weight loss.

Serious Side Effects of Ozempic and Wegovy

Ozempic and Wegovy have shown effectiveness in weight management for many. Yet, it’s crucial to be aware of its serious side effects.

  • Pancreatitis: Patients may experience severe pain in the abdomen that doesn’t go away. This pain often reaches the back and may come with vomiting.
  • Gallbladder Problems: Nearly 193 incidents have been reported where users faced severe issues, including gallstones and inflammation.
  • Kidney Injury or Failure: Serious cases of kidney damage have occurred, sometimes requiring dialysis.
  • Severe Allergic Reactions: There have been reports of anaphylaxis, a life-threatening allergic reaction needing immediate treatment.
  • Increased Heart Rate: Users might notice their heart beating faster than usual, which could signal underlying problems.
  • Diabetic Retinopathy Complications in Patients with Type 2 Diabetes: Among those using Wegovy, there’s a risk that vision problems related to diabetes can get worse.
  • Depression or Thoughts of Suicide: The medication has led some to feel unusually sad or have thoughts about harming themselves.
  • Acute Pancreatitis: Sharp and severe abdominal pain signaling pancreatitis is a critical condition requiring prompt medical attention.

Practical Considerations

When choosing between Ozempic and Wegovy, consider how often each medicine needs to be taken, who can safely use it, and how much it costs.

Dosing Schedules for Ozempic

  • Start with a low dose of 0.25 mg once a week for the first four weeks. This initial period helps your body adjust to the medication.
  • After four weeks, increase the dosage to 0.5 mg once weekly. This is the typical starting dose for continuing treatment.
  • If more control over blood sugar levels is needed, or if weight loss results are insufficient, the dose can be increased to 1 mg once a week after at least four weeks.
  • For some patients, a higher dose may be necessary for optimal results. After evaluating effectiveness and tolerability, the dose can be increased to 2 mg once weekly.
  • Patients must receive instructions on storing Ozempic properly before use; it requires refrigeration at 2°C to 8°C (36°F to 46°F) until its first use.
  • Once you use the pen, keep it at room temperature, not above 30°C (86°F), or refrigerate it for up to 56 days.

Dosing Schedules for Wegovy

Wegovy is a medication used for weight loss. It has a specific dosing schedule that healthcare providers should follow closely.

  • Wegovy’s start dose is 0.25 mg once weekly for the first four weeks. This beginning period helps patients adjust to the medication.
  • After the first month, increase the dose to 0.5 mg once weekly for another four weeks. This gradual increase continues to help with adjustment and starts to show effects on weight loss.
  • The third step involves increasing the dose to 1 mg once a week after completing two months on Wegovy. By this time, most patients will have noted some changes in their appetite.
  • Next, after three months of treatment, the dose increases to 1.7 mg once weekly, further accelerating weight loss progress.
  • Finally, the target dose for ongoing treatment is 2.4 mg once a week after at least four months on Wegovy.

Patient Selection Criteria for Ozempic and Wegovy

Doctors often prescribe Ozempic for adults with type 2 diabetes who need help with weight loss. It works best for those already managing blood sugar through diet and exercise but still find their levels too high. However, it’s not suitable for everyone. Doctors check kidney function and avoid prescribing it to those with severe kidney problems or certain digestive issues.

Wegovy is recommended for adults with obesity or overweight individuals with at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol. Candidates should have a BMI of 30 kg/m² or higher, or 27 kg/m² with related conditions. Wegovy is most effective alongside lifestyle changes like healthier eating and increased physical activity. 

Cost Comparison Between Ozempic and Wegovy

  • Average Monthly Cost: Ozempic typically costs around $800 to $1,000 per month, depending on the dosage prescribed. Meanwhile, Wegovy, the higher-dose version of semaglutide, is more expensive. It averages around $1,200 to $1,500 per month.
  • Insurance Coverage: Many health insurance plans cover Ozempic and Wegovy, but copay amounts vary. Patients should check with their insurance provider for specific details.
  • Patient Assistance Programs: Novo Nordisk, the manufacturer of Ozempic and Wegovy, offers patient assistance programs to help eligible individuals access medication at a reduced cost.


Choosing between Ozempic and Wegovy for weight loss depends on several things. Each has its way of working, side effects, and how often you take them. They also differ in costs and who should use them. Think about these points carefully before deciding which is best for your needs.


1. How do I use Ozempic for weight loss? 

Ozempic is administered via weekly injections under the skin. To ensure efficacy, follow precise instructions and store it refrigerated.

2. Can you compare Ozempic with Saxenda and Trulicity? 

Ozempic, Saxenda, and Trulicity are all utilized in weight loss treatments but differ in ingredients and potential side effects.

3. What are some long-term side effects of using Ozempic? 

Long-term side effects of Ozempic can include gastrointestinal issues or changes in vision, though individual reactions vary.

4. Are there visible results from using Ozempic? 

Many users report significant weight loss with Ozempic, supported by numerous before-and-after success stories.


DeSilver D. As obesity rates rise in the U.S. and worldwide, new weight-loss drugs surge in popularity. Pew Research Center. Published March 21, 2024. https://www.pewresearch.org/short-reads/2024/03/21/as-obesity-rates-rise-in-the-us-and-worldwide-new-weight-loss-drugs-surge-in-popularity/ 

Cardiovascular Benefit of Ozempic® (semaglutide) injection 0.5 mg, 1 mg, or 2 mg. novoMEDLINK. https://www.novomedlink.com/diabetes/products/treatments/ozempic/cardiovascular-benefit.html



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