Business Hours: Monday-Friday 9AM-6PM EST

Featured Image

Latisse Long-Term Side Effects – How to Avoid

David Fuller

Last Updated On: June 5, 2024

Did you know eyelashes typically take about six weeks to grow back if they fall out? Various factors, including health conditions and cosmetic treatments, can influence this natural growth cycle. Latisse has become a popular choice among treatments designed to enhance eyelash growth.

Originally developed to treat glaucoma, Latisse was found to have the beneficial side effect of promoting longer, thicker eyelashes. However, its use has potential long-term side effects. Users must be well-informed about these risks, as understanding them can empower them to make responsible decisions and take steps to mitigate adverse effects.

In this article, we will explore the science behind Latisse, discuss its potential long-term side effects, and provide tips on how to avoid them.

Key Takeaways

  • Latisse, also known as bimatoprost, is a popular prescription medication to enhance eyelash growth.
  • Long-term use of Latisse may lead to potential side effects such as eyelid darkening, eye irritation, and changes in eyelash color.
  • Understanding the underlying mechanisms, prevalence, and risk factors for these side effects is crucial for medical professionals to ensure the safe use of Latisse.
  • Minimizing risks and preventing long-term side effects can be achieved through proper application techniques and patient education.
  • Expert insights and case studies provide practical guidance on managing and preventing long-term side effects of Latisse.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to buy Latisse online, contact our sales department for more information.

Potential Long-Term Side Effects of Latisse

Latisse can lead to some lasting side effects. These include changes in eyelid color and how your lashes or eyes feel.

  • Eyelid Darkening: A potential side effect of using Latisse lash serum as the active ingredient can affect the skin around the eyes. The good news is that discontinuing the use of Latisse usually results in the darkening fading within a few weeks or months.
  • Eye Irritation: Latisse, known for growing lashes, can sometimes irritate, including red and itchy eyes. To prevent this, it’s essential to apply the serum carefully and avoid direct contact with the eye.
  • Changes in Eyelash Color: Latisse can darken eyelashes, which is usually desired, but it may also darken eye color. Rarely, blue, green, or hazel eyes may turn brown due to increased melanin. This iris color change is often permanent, even after stopping Latisse’s use.

Mechanisms and Prevalence of Long-Term Side Effects

Latisse can cause long-term side effects, including eyelid darkening and eye color changes. These occur because Latisse increases melanin production, darkening skin and eyes. While it effectively lengthens and thickens lashes, it may also stimulate melanocytes, increasing pigmentation. 

Some users, especially those with lighter eyes, experience a permanent change in iris color. Additionally, Latisse can lower intraocular pressure, which is important for maintaining eye health and avoiding glaucoma. Although not everyone experiences these effects, they are notable risks. Stopping Latisse can reverse some changes, but eye color alterations might be permanent.

Risk Factors for Long-Term Side Effects

Some people may have a higher chance of facing long-term side effects from Latisse. Key factors include how often you use it and your body’s reaction to its active ingredients.

Factors that Increase the Risk of Experiencing Long-term Side Effects

Latisse, known for its active ingredient that promotes eyelash growth, can have side effects over the long term. Users and medical professionals must understand what increases the risk of these adverse effects.

  • Overuse can lead to side effects like eyelid darkening and eye irritation.
  • Incorrect application may cause unwanted hair growth and skin pigmentation changes.
  • Extended use without breaks may result in persistent darkening of eyelids or changes in iris color.
  • People with pre-existing eye conditions may experience complications with Latisse use.
  • Genetic predisposition to pigment changes may lead to skin darkening around the eyes.
  • Pregnant individuals should use Latisse with caution due to potential risks.
  • Combining Latisse with other eye treatments may trigger additional side effects.

Minimizing Risks and Preventing Long-Term Side Effects

Using the proper Latisse dosage is key to avoiding long-term side effects. Medical professionals need to guide patients in applying this eyelash serum correctly.

  • Wash hands and face thoroughly before applying Latisse to ensure cleanliness.
  • Ensure the face is makeup-free and contact lenses are removed.
  • Apply one drop of Latisse on the provided applicator brush.
  • Gently sweep the applicator along the upper eyelid lash line from the inner to the outer edge.
  • Blot excess solution with a tissue to avoid unwanted hair growth or skin darkening.
  • Use a new applicator for the other eye to maintain hygiene.
  • Avoid applying Latisse to the eyes or lower eyelash line to prevent irritation.
  • Dispose of each applicator after use to prevent infection.
  • Apply once daily, preferably at night, for best results.
  • Educate patients to monitor their eye condition and report any changes immediately.

Patient Education on Potential Side Effects and How to Recognize Them

Educating patients about Latisse’s side effects is crucial. Inform them of potential eyelid darkening, eye irritation, and eyelash color changes. Highlight that iris discoloration can permanently turn blue, green, or hazel eyes brown. Emphasize spotting these signs early and understanding their permanence. Stress precise application to avoid unwanted hair growth and skin darkening.

Expert Insights and Case Studies on Managing Long-Term Side Effects

Doctors advise careful application of Latisse to minimize side effects like eyelid and iris darkening. They recommend applying the product only on the upper lash line and discontinuing its use if severe reactions occur. Educating patients on potential outcomes and correct application methods is crucial for short-term satisfaction and long-term safety. 

“I have been a lash girl for a while but due to time can’t have them done and was recommended Latisse. The clinic was super easy to get in and out and on day three I SWEAR my lashes already have improvements. I was expecting 6wk+. I couldn’t be more pleased. It’s very easy to apply.”

Experts suggest using eye drops to soothe eye irritation and applying less Latisse to address skin darkening. Proper application techniques have helped prevent issues such as changes in eyelash color and orbital fat loss.

“Latisse is amazing. No issues whatsoever. Photos are with the same mascara used (although I’m smiling in the top photo, you can completely see the difference) – about 12 weeks between photos. I only used one drop for both eyes (as opposed to using two drops per instructions). I put one drop into the lid and used a brush for both eyes, then ran the brush over my eyebrows…”

Making patients aware of this information is crucial for maintaining their trust. This will also help them prepare for the results and reduce their anxiety.


Using Latisse correctly can help avoid long-term side effects. Knowing the risks can also help you stay safe. Talk to a doctor if you see changes in your eyes or eyelids. They can guide you on what to do next. Keeping your eyes healthy is key to enjoying longer lashes with Latisse.


1. What is the concern with Latisse and orbital fat loss? 

Latisse can cause orbital fat loss in some users, leading to a hollow appearance around the eyes. This side effect is not universal, and careful application may reduce the risk.

2. Can I use Latisse if I’m pregnant or planning to be? 

Latisse is not recommended during pregnancy due to a lack of safety studies in pregnant women. It is advisable to avoid using Latisse until after childbirth.

3. Is there a difference between Latisse and GrandeLash? 

Yes, Latisse and GrandeLash contain different active ingredients and work differently. They are chosen based on individual lash goals and skin compatibility.

4. How can hypopigmentation be avoided with Latisse? 

Hypopigmentation, or lightening of the skin, can occur with Latisse use. Careful and precise application can help minimize this risk.


How Long Does It Take for Eyelashes to Grow Back? Influencing Factors. Healthline. Published November 11, 2020. Accessed May 22, 2024. https://www.healthline.com/health/how-long-does-it-take-for-eyelashes-to-grow-back#eyelash-growth

Latisse: Side Effects, Dosage & Uses. Drugs.com. Accessed May 22, 2024. https://www.drugs.com/latisse.html#side-effects



Log In


Subscribe for exclusive offers and updates on new arrivals




Share feedback at:

[email protected]

Working Hours

Monday to Friday: 9 AM to 6 PM (EST)

The Most Popular Brands

Copyright 2024. Med Supply Solutions