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Hyalgan vs Supartz – Which is Better?

David Fuller

Last Updated On: June 5, 2024

Osteoarthritis is a degenerative disease in the joints that often persists for decades, requiring a range of pharmaceutical and nonpharmaceutical interventions. Intra-articular injections (IAJs) are a crucial first-line treatment. Among these, Hyalgan and Supartz are popular hyaluronic acid-based options for knee osteoarthritis.

These treatments aim to restore joint lubrication and cushion the knee, alleviating pain and enhancing mobility. Understanding the benefits and differences between Hyalgan and Supartz can help patients make informed decisions about effectively managing their osteoarthritis.

This article will explore the efficacy, side effects, and overall patient satisfaction of each treatment.

Key Takeaways

  • Hyalgan and Supartz are both hyaluronic acid-based viscosupplementation treatments for knee osteoarthritis.
  • Both treatments aim to relieve joint pain and improve mobility in patients with knee osteoarthritis.
  • Clinical efficacy, safety profiles, injection protocols, duration of pain relief, practical considerations, patient preferences, and potential side effects are important factors to consider when comparing these treatments.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to order Hyalgan online, contact our sales department for more information.

Introduction to Hyalgan and Supartz

Hyalgan and Supartz are popular treatments for knee osteoarthritis. They involve hyaluronic acid injections directly into the knee joint. Hyalgan, used worldwide for 28 years, provides long-lasting pain relief. Similarly, Supartz, derived from chicken combs’ hyaluronic acid, offers effective pain management. 

While neither treatment repairs damaged cartilage, it improves mobility and reduces pain. Studies suggest Hyalgan and Supartz may be cost-effective compared to similar treatments. The choice between them often depends on individual preferences and treatment responses. 

Clinical Efficacy and Safety Profiles

Exploring the clinical efficacy of Hyalgan and Supartz reveals intriguing findings from key studies and clinical trials. These outcomes are central to understanding which treatment option may offer better knee osteoarthritis pain relief results. Here’s a comprehensive comparison in a summarized form:

Clinical EfficacyStudies show that Hyalgan can relieve osteoarthritis knee pain long-lastingly. It has been effective for 28 years globally, indicating significant positive patient outcomes.Effective pain relief for knee osteoarthritis, with some studies indicating comparable efficacy to Hyalgan. The choice may depend on individual patient responses.
Safety ProfileLong track record of safety across multiple populations. Well-tolerated with minimal adverse effects.Similar to Hyalgan, it is well-tolerated with a strong safety profile. Adverse effects are rare and generally mild.
Key Studies and TrialsVarious clinical trials underline its efficacy in relieving knee pain, with some patients experiencing benefits for up to 6 months post-treatment.Although direct head-to-head trials are limited, comparable studies highlight effective pain management for knee osteoarthritis.

Injection Protocols and Duration of Pain Relief

Hyalgan and Supartz differ in the number of shots you get. The relief from joint pain lasts different times for each. The number of injections required can vary significantly between these two treatments.

  • Hyalgan Treatment Protocol: Patients typically undergo a series of five injections of Hyalgan, given once a week for five weeks.
  • Supartz Injection Schedule: Conversely, Supartz may offer flexibility in its regimen. Patients might receive three to five injections depending on their response to the treatment.
  • Duration Between Courses: After completing their initial series of Hyalgan or Supartz injections, patients may not require another course for six months or longer, depending on how well they respond to the treatment.
  • Patient Response Variability: Some patients report pain relief after just one Hyalgan injection, though full benefits usually come after completing the entire series. Similarly, with Supartz, some may feel improvement sooner within the treatment course.
  • Follow-up Treatments: Both treatments allow for repeat courses if knee pain returns and if the patient responds well to the initial injections without significant side effects.

Practical Considerations and Patient Preferences

Understanding the cost implications of Hyalgan and Supartz treatments is crucial for medical professionals. This consideration aids in making informed decisions for patients with knee osteoarthritis pain. Below is a comparative overview of the costs associated with Hyalgan and Supartz treatments.

TreatmentAverage Cost Per InjectionTotal Cost for Full Treatment CourseNotes
Hyalgan$200-$300$1000-$1500Based on a typical 5-injection regimen.
Supartz$200-$300$1000-$1500It can vary based on 3-5 injections needed.

Patient Preferences and Considerations for Treatment Selection

Choosing between Hyalgan and Supartz can be challenging. Both treatments cater to patients seeking relief from knee osteoarthritis, but various factors influence the final decision.

  • Effectiveness: Patients often weigh how well each treatment works. Since both Hyalgan and Supartz are created for pain relief, knowing that Hyalgan injections provide long-lasting relief may sway some.
  • Safety History: Hyalgan has been used safely for many years, so patients might lean toward it due to its proven track record.
  • Cost: Since the comparison shows that Supartz over Hyalgan had lower disease-specific costs than other options, this could be a significant deciding factor for patients on a budget.
  • Injection Frequency: The number of injections varies between the two treatments, impacting patient convenience and preference.
  • Duration of Relief: Patients consider how long they will benefit from each treatment before choosing; more extended relief periods are more appealing.
  • Side Effects: Understanding the potential side effects of Hyalgan and Supartz is critical. Patients prefer options with manageable or fewer side effects.
  • Availability: Access to either treatment can vary by location so that availability might limit choices.
  • Personal Response to Treatment: Some individuals may respond better to one treatment than another based on previous experiences or individual health profiles.
  • Physician Recommendation: Patients often rely on their doctor’s expertise to choose between Hyalgan vs Supartz or other alternatives like Euflexxa and Orthovisc.
  • Insurance Coverage: The extent of coverage for each option can significantly affect decision-making since out-of-pocket costs vary widely between insurance plans.

Potential Side Effects and Management

Hyalgan and Supartz treatments may cause side effects like pain, swelling, or heat at the injection site. While usually mild and temporary, rare serious reactions like infections or allergies can occur. Prompt recognition and management are crucial. 

Physicians use specific codes like the Hyalgan injection CPT code for accurate documentation and billing. Understanding potential side effects aids in tailored treatment approaches for knee osteoarthritis. 

Management Strategies for Mitigating Side Effects

Knowing the potential side effects of treatments is crucial. It’s also vital to have strategies to deal with these side effects effectively.

  • Educate patients on possible side effects of Hyalgan or Supartz injections, such as pain and swelling at the injection site.
  • Recommend using ice packs to reduce swelling and discomfort.
  • Advise avoiding strenuous activities or heavy use of the injected joint for 48 hours.
  • Prescribe safe over-the-counter pain relievers if necessary.
  • Monitor patients for signs of infection or allergic reactions and prepare for immediate care if needed.
  • Encourage reporting any unusual symptoms or prolonged side effects after the injection.
  • Discuss the importance of a balanced diet and maintaining a healthy weight to reduce joint stress.
  • Consider physical therapy to improve joint function.
  • Schedule follow-up appointments to assess side effects management.
  • Customize care plans based on each patient’s response to treatment.


Choosing between Hyalgan and Supartz comes down to what works best for the patient. Both offer relief from knee osteoarthritis pain and have a strong safety record. Patients have unique responses to each treatment. Some might find better results with Hyalgan, while others prefer Supartz. It’s all about matching the right solution to individual needs and preferences for effectively managing knee pain.


1. What’s the difference between Hyalgan and Supartz?

The main difference between Hyalgan and Supartz is how often you need them. Hyalgan might be given more frequently than Supartz at the start.

2. Is Hyalgan or Euflexxa better for knee pain?

Some people find Euflexxa works better for knee pain from osteoarthritis because it’s newer, but it depends on your body’s reaction.

3. Can I choose Hyalgan over Orthovisc?

To treat knee pain due to osteoarthritis, you can choose Hyalgan over Orthovisc. Your choice might depend on your doctor’s suggestion and your health needs.

4. Where do I find prescribing information for Hyalgan?

You can get all the prescribing info you need for Hyalgan from your healthcare provider or official medical websites.


Pavone V, Vescio A, Turchetta M, Giardina SMC, Culmone A, Testa G. Injection-Based Management of Osteoarthritis of the Knee: A Systematic Review of Guidelines. Front Pharmacol. 2021;12:661805. doi: 10.3389/fphar.2021.661805

https://www.facebook.com/WebMD. Hyaluronan Injections for Knee Osteoarthritis. WebMD. https://www.webmd.com/osteoarthritis/hyaluronan-injections-knee 



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