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Hyalgan vs Euflexxa – A Thorough Comparison

David Fuller

Last Updated On: June 21, 2024

According to the World Health Organization, osteoarthritis is the most common form of arthritis, affecting millions worldwide. Although osteoarthritis can damage any joint, the disorder most commonly affects the joints in a person’s hands, knees, hips, and spine.

Hyalgan and Euflexxa are viscosupplements used to treat osteoarthritis by enhancing joint lubrication and cushioning, helping to alleviate pain and improve mobility. They offer non-invasive options for managing osteoarthritis symptoms effectively.

In this article, we’ll explore the nuances of Hyalgan and Euflexxa, weigh their pros and cons, and highlight their safety and potential side effects.

Key Takeaways

  • Hyalgan and Euflexxa are both hyaluronic acid-based treatments for knee osteoarthritis.
  • These treatments’ composition and mechanism of action differ, potentially impacting their clinical efficacy and safety profiles.
  • Clinical studies have shown variations in treatment outcomes, patient satisfaction, and duration of pain relief between Hyalgan and Euflexxa.
  • Safety profiles, including common and rare side effects, should be considered when choosing between the two treatments.
  • Practical aspects such as the number of injections required, cost considerations, and ease of administration play a role in treatment selection.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to order Hyalgan online, contact our sales department for more information.

Introduction to Viscosupplementation and Osteoarthritis Management

Hyalgan and Euflexxa are options for knee osteoarthritis pain. Both mimic natural joint fluid, aiding in pain management without surgery. Hyalgan contains egg products, whereas Euflexxa does not, catering to allergies.

Treatment plans and costs vary, with Euflexxa often requiring three shots compared to one for some alternatives. This comparison clarifies differences. Viscosupplementation involves injecting hyaluronic acid into the knee to lubricate and cushion, offering relief when other treatments fail. Hyalgan’s few side effects make it a safe choice. 

Both treatments aim to improve knee movement and reduce discomfort without relying heavily on oral medication. They offer different options within the viscosupplementation approach to managing knee osteoarthritis, relieving everyday tasks by easing pain and stiffness.

Composition and Mechanism of Action of Hyalgan and Euflexxa

Hyalgan and Euflexxa are both treatments for knee osteoarthritis that involve injecting hyaluronic acid directly into the knee joint to relieve pain. The significant difference between the two lies in their composition; Hyalgan includes egg products, making it unsuitable for people with egg allergies, while Euflexxa does not contain any egg products. 

Both treatments aim to supplement the body’s natural hyaluronic acid, which may be lower in people suffering from osteoarthritis, to reduce pain and improve mobility.

Clinical Efficacy and Outcomes

Seeing how well Hyalgan and Euflexxa work can help determine which helps more with knee pain. Euflexxa and Hyalgan injection reviews shared by other patients may help guide making an informed decision and achieving the best results.

Key Studies on the Efficacy of Hyalgan

  • A prospective cohort study evaluated the long-term efficacy and safety of five weekly intra-articular injections of Hyalgan in 76 patients (92 knees) with moderate to severe knee osteoarthritis (OA). These patients had pain that was not adequately controlled by conventional measures. The study found that Hyalgan provided significant pain relief, and the treatment was generally well-tolerated.
  • In a 30-month study, Hyalgan was safe for repeat treatment. Patients who require additional treatment cycles can receive Hyalgan without compromising safety. In clinical studies, a single cycle (consisting of five injections) of Hyalgan provided pain relief for up to six months.

Key Studies on the Efficacy of Euflexxa

Euflexxa, an injectable solution for knee pain in osteoarthritis patients, has been studied closely. Many patients report improved quality of life thanks to this treatment.

  • A prospective randomized, double-blind study compared Euflexxa to Synvisc in 321 patients with stage 2-3 knee osteoarthritis (OA). The primary endpoint was pain relief, measured as the mean change from baseline in Western Ontario and McMaster University Osteoarthritis Index (WOMAC) pain scores. Euflexxa demonstrated powerful pain relief, and a significant proportion of Euflexxa patients were pain-free at the end of the 12-week study.
  • In a randomized, double-blind, placebo-controlled study (FLEXX Trial) with 588 knee OA patients, Euflexxa was compared to saline. Euflexxa was proven superior to saline in reducing OA knee pain, and a significant percentage of Euflexxa patients were pain-free at 6 months.

Patient Satisfaction

Patients seek relief from knee pain due to osteoarthritis with Hyalgan’s direct solution through injections. Euflexxa users rate the treatment 6.1 out of 10, with 55% reporting positive outcomes, suggesting satisfaction among those seeking alternatives. Individual responses, preferences, allergies, and treatment regimen requirements play a role in choosing between Euflexxa and other options like Orthovisc.

Duration of Pain Relief

Hyalgan injections offer up to six months of relief from knee osteoarthritis pain, improving daily functionality. Supported by clinical studies, it’s effective in long-term symptom management.

Meanwhile, Euflexxa provides similar relief, acting as natural joint fluid, with effects lasting up to six months. Adjusting dosage and treatment plans is crucial for sustained comfort and mobility.

Safety Profiles and Side Effects

Common side effects of Hyalgan and Euflexxa, both osteoarthritis treatments, include pain and swelling at the injection site. Rare side effects may include allergic reactions or infection. Monitoring for these effects is crucial during treatment.

  • Pain at the injection site can happen, making the area feel tender or sore for a few days.
  • Swelling around the knee is another side effect, as the body reacts to the injection.
  • Redness and warmth at the injection area are often reported, indicating a minor inflammatory response.
  • Bruising might appear where the needle entered due to damage to small blood vessels.
  • Itching can occur around the knee or at the injection site, usually mild and temporary.
  • Stiffness in the knee joint might be felt initially but generally eases with time.
  • Some patients have mentioned headaches after receiving these injections.
  • Nausea or feeling sick could happen shortly after treatment but tends not to last long.
  • Muscle pain or cramps in areas near the injection site are possible but usually resolve independently.
  • Fever or flu-like symptoms have been experienced by a few people following their treatment.

Practical Considerations

When choosing between Hyalgan and Euflexxa for knee osteoarthritis, consider shot counts, costs, and simplicity. For Hyalgan injections, these treatments require five weekly injections. As for Euflexxa, healthcare professionals often administer three injections a week apart. 

Patients must also consider costs. Though Euflexxa may have higher initial costs than Hyalgan, its effectiveness and longer duration of pain relief justify the investment. Evaluating treatment outcomes and costs is essential for informed decisions, with medical professionals guiding based on clinical needs and financial considerations.


Individual needs must be considered when deciding between Hyalgan and Euflexxa for knee osteoarthritis. Both treatments offer pain relief with varying side effects and patient satisfaction. Consulting a healthcare provider is crucial to determining the best option based on medical history and treatment goals.


1. What distinguishes Hyalgan from Euflexxa?

Hyalgan is derived from rooster combs, while Euflexxa is synthesized in a laboratory.

2. Do Hyalgan and Euflexxa both alleviate knee pain?

Yes, they are both effective in relieving knee pain.

3. How are Hyalgan and Euflexxa administered by doctors?

They are administered via direct injection into the knee joint.

4. Is a series of injections necessary for Hyalgan or Euflexxa to be effective?

Multiple injections over several weeks may be required for optimal results.

5. Are there potential side effects associated with Hyalgan or Euflexxa?

Possible side effects include localized swelling or pain at the injection site, though severe reactions are rare.


World Health Organization. Osteoarthritis. www.who.int. Published July 14, 2023. https://www.who.int/news-room/fact-sheets/detail/osteoarthritis 

Efficacy – Euflexxa. hcp.euflexxa.com. https://hcp.euflexxa.com/efficacy/ 

Clinical Studies – Hyalgan for Healthcare Professionals. https://hcp.hyalgan.com/hcp/clinical-studies/ 



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