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Comparing Xeomin vs Dysport: Which Lasts Longer?

David Fuller

Last Updated On: June 20, 2024

Minimally invasive cosmetic procedures have witnessed a remarkable surge in popularity, with millions of people seeking non-surgical solutions to enhance their appearance. According to recent data, neurotoxin injections account for a significant portion of these procedures. Among the contenders in this field, Xeomin and Dysport stand out as powerful alternatives to the well-known Botox.

Xeomin and Dysport are injectable treatments targeting wrinkles and fine lines by temporarily relaxing facial muscles. Like Botox, they belong to the class of botulinum toxin type A products. However, they differ in their formulations and diffusion properties. 

In this article, we’ll explore the similarities and differences between Dysport and Xeomin, focusing on their effectiveness and the longevity of their effects in cosmetic and therapeutic applications.

Key Takeaways

  • Xeomin and Dysport are both neurotoxin treatments used in medical aesthetics and therapeutic settings.
  • Understanding the pharmacokinetics, mechanism of action, and duration of effects is crucial for medical professionals to make informed decisions when selecting the most appropriate treatment option for their patients.
  • Practical considerations such as dosing strategies, injection techniques, and patient preferences significantly optimize treatment outcomes and enhance patient satisfaction.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to order Xeomin online, contact our sales department for more information.

Understanding Xeomin and Dysport

Xeomin, produced by Merz Aesthetics, is a botulinum toxin used to smooth frown lines and treat conditions like cervical dystonia. Its pure form without complex proteins may lead to fewer immune reactions. It’s used for various needs, including under-eye bags and jawline shaping. Results last three to six months, making regular treatments preferred to maintain effectiveness.

Overview of Dysport

Dysport, made by another leading company, is an injectable treatment primarily used to reduce frown lines between the eyebrows. It also targets other facial areas by relaxing muscles through nerve signal blocking. 

Dysport often shows results within a few days, smoothing the skin as early as 2-3 days post-treatment. Its effects last up to four months, making it a popular choice for longer-lasting outcomes, especially for those seeking fewer touch-ups.

Key Similarities and Differences Between Xeomin and Dysport

Xeomin and Dysport offer innovative solutions for reducing the appearance of fine lines and wrinkles, such as how Xeomin in frown lines works. Yet distinct features set them apart. Here’s a quick comparison to shed light on their key similarities and differences, all while keeping the needs of medical professionals in mind.

Core ingredientBotulinum toxin type ABotulinum toxin type A
Protein presenceLacks complexing proteinsContains complexing proteins
Onset of actionFive to seven daysFaster, within 2-3 days
Duration of effectTypically 3-6 months, with a need for periodic touch-upsAround 3-6 months, similar to Xeomin but may require less frequent touch-ups
Average longevity in males115-121 days115-121 days
Average longevity in females139-146 days139-146 days
Molecular size and structureSmaller molecular size due to absence of complexing proteinsLarger due to the presence of proteins
Diffusion characteristicsTends to have a more localized effectMay spread to adjacent areas more readily

Pharmacokinetics and Mechanism of Action

Understanding the pharmacokinetics of Xeomin and Dysport is crucial in comprehending their effects on muscles. Both neurotoxins work by blocking nerve signals, leading to muscle relaxation. However, differences in their formulations and protein structures influence their onset of action and duration. Xeomin’s pure formulation without complex proteins may result in a faster onset than Dysport’s.

  • Molecular Size and Protein Structure: They differ in molecular structure, affecting their spread after injection. Xeomin lacks complex proteins, resulting in a smaller molecule size than Dysport. This allows for more precise targeting of specific areas without affecting surrounding tissues much. With additional proteins, Dysport diffuses more across the treated area, making it suitable for broader treatment zones. 
  • Diffusion Characteristics: Dysport tends to spread more, making it faster on larger areas but with a risk of inadvertently affecting nearby muscles. With its pure form, Xeomin stays closer to the injection site, making it ideal for precise treatments like between the eyebrows. Doctors choose between them based on patient needs and treatment area size.
  • Onset of Action for Xeomin and Dysport: Xeomin takes about five to seven days to show full effects, while Dysport typically works within a couple of days. Dysport’s quicker action makes it suitable for those seeking immediate results, with effects lasting up to four months. Although slower to show results, Xeomin is beneficial for the long-term treatment of conditions like cervical dystonia and frown lines. 

Duration of Action and Longevity

Exploring the longevity of Xeomin and Dysport through clinical studies offers insightful data for medical professionals, highlighting differences in patient outcomes. These studies serve as a comparative guide, shedding light on each neuromodulator’s expected duration of effects.

Real-world Experiences and Patient Outcomes

Doctors and patients often report different results with Xeomin and Dysport. Many find that while both treatments ease frown lines, each person’s body reacts differently. This means the time it takes to see changes and how long they last can vary.

Xeomin typically starts showing effects within 3 to 4 days after treatment. Patients notice a gradual reduction in wrinkles or muscle stiffness over several days. The total effect becomes apparent in a couple of weeks, with targeted muscles fully relaxed.

Some patients combine Xeomin with other treatments, such as dermal fillers or laser therapies, for comprehensive facial rejuvenation. Discussing combination approaches with a skilled provider can yield impressive results.

Practical Considerations for Medical Professionals

Choosing the right dose for Xeomin and Dysport is key to achieving the desired results. Understanding each product’s unique characteristics helps in fine-tuning treatment plans.

  • Start with the manufacturer’s recommended dose. This serves as a baseline. Both Xeomin and Dysport come with guidelines that suggest starting doses based on treatment areas.
  • Consider patient characteristics. Males often need higher doses than females due to stronger muscle mass. 
  • Tailor the dose for specific areas. For instance, treating under-eye bags might require less Xeomin compared to forehead lines.
  • Adjust doses based on previous outcomes. If patients report shorter-than-expected results from their initial treatment, consider increasing the dosage slightly during their next visit.
  • Take into account the onset of action. Since Xeomin can take five to seven days to show full effects, wait before deciding if a top-up is needed.
  • Monitor patient satisfaction and side effects closely after each session. This feedback will guide future dosing adjustments, ensuring an optimal balance between efficacy and safety.
  • Account for the longevity of desired effects. Both products generally last 3 to 6 months, but individual responses can vary widely, necessitating tailored maintenance schedules.

Patient Preferences and Satisfaction

Patients often choose between Xeomin and Dysport based on the speed of results and duration of effects. Dysport’s rapid onset, noticeable within days, appeals to many. Xeomin’s effects last three to six months, requiring fewer touch-ups but taking longer to manifest. 

Patient satisfaction also depends on treatment experience and individual factors like age and gender, which influence treatment effectiveness and duration. Understanding these differences helps doctors advise patients and set realistic expectations.


Comparing Xeomin and Dysport’s duration of action and longevity provides medical professionals valuable insights into their relative strengths and limitations. By understanding the pharmacokinetics, mechanism of action, and practical considerations for these neurotoxin treatments, medical experts can make evidence-based decisions to optimize clinical outcomes in both aesthetic and therapeutic settings.


1. What are Xeomin and Dysport used for?

Xeomin and Dysport, both from different companies, are used to smooth out wrinkles. They are FDA-approved for their safety and effectiveness in rejuvenating one’s appearance.

2. How soon does Xeomin show results?

Xeomin starts working fairly quickly! You may notice changes within a few days after treatment. However, waiting up to two weeks is recommended to see the full effect.

3. Which lasts longer, Xeomin or Botox?

Xeomin and Botox are similar, typically lasting around 3 to 4 months before another treatment is needed.

4. Can Xeomin be used for under-eye bags?

Absolutely! Doctors can use Xeomin around the eyes to effectively reduce under-eye bags, ensuring that you look as good on the outside as you feel on the inside.


American Society of Plastic Surgeons. The American Society of Plastic Surgeons ® Procedural Statistics Data Insights Partners: 2022 ASPS Procedural Statistics Release.; 2023. https://www.plasticsurgery.org/documents/News/Statistics/2022/plastic-surgery-statistics-report-2022.pdf

Xeomin vs. Dysport: Which is Better? – HealthPlugged. Published December 30, 2022. Accessed May 2, 2024. https://healthplugged.com/xeomin-vs-dysport/



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