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Xeomin After Reconstitution: Usage Guidelines

David Fuller

Last Updated On: June 23, 2024

According to the latest report from the American Society of Plastic Surgeons (ASPS), treatment operations involving neuromodulators surged to an impressive 8 million in 2022. This remarkable statistic highlights the growing popularity of neuromodulators in aesthetic medicine today. 

Xeomin is a neuromodulator that behaves similarly to its more famous counterpart, Botox. However, Xeomin isn’t like other botulinum toxins because of its unique formulation, increasing Xeomin’s prominence among patients seeking smoother, more youthful skin.  

In this article, we delve into the science behind Xeomin, explore its applications beyond wrinkle reduction, and discuss why it’s capturing the attention of both patients and practitioners. 

Key Takeaways

  • Reconstitution of Xeomin is crucial for maintaining its integrity and efficacy.
  • Dosage calculations for Xeomin after reconstitution should be carefully determined based on the specific indication and patient factors.
  • Proper storage conditions and shelf-life considerations are essential for preserving the potency of reconstituted Xeomin.
  • Adhering to best practices for injection techniques and administration protocols is vital for the safe and effective use of Xeomin.
  • Practitioners should be equipped to recognize and manage potential adverse reactions post-Xeomin administration.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to buy Xeomin online, contact our sales department for more information.

Reconstitution Process for Xeomin

Properly mixing Xeomin is crucial for its success. Reconstitution turns Xeomin powder into a liquid, a vital step for its safety and effectiveness. Incorrect mixing can lead to risks or ineffective treatment. Following strict guidelines for mixing, storing, and handling Xeomin ensures safe and effective use for treating frown lines or cervical dystonia.

A Step-by-step Guide to Reconstituting Xeomin

Reconstituting Xeomin correctly is crucial for its effectiveness and safety. You must follow the prescribed steps to ensure product integrity. Here’s how you can do it:

  • Start by ensuring all materials are clean and the work area is sterile.
  • Take out the Xeomin vial from its packaging. Check the label to make sure it hasn’t expired.
  • Gently clean the rubber stopper on the vial with an alcohol swab to avoid infection.
  • Next, use a syringe to draw up the saline solution for reconstitution. The amount depends on your needed dosage.
  • Slowly inject the saline into the Xeomin vial through the rubber stopper. Be careful not to create bubbles, as this could affect concentration.
  • Once injected, gently swirl the vial to mix the solution and Xeomin powder. Do not shake it vigorously, as this might damage the product.
  • After mixing, let it sit briefly to allow any bubbles to settle. 
  • Check that the solution is clear and without particles before proceeding with administration.

Dosage Calculations for Xeomin After Reconstitution

Determining the appropriate dosage of Xeomin post-mixing is crucial and requires finding the right balance for each patient, ensuring it’s neither insufficient nor excessive. Tailoring the dosage is essential for various issues like frown lines or under-eye bags, considering factors such as line depth or muscle size.

Precision is critical, especially when treating conditions like cervical dystonia. It’s vital to adhere to guidelines to avoid under and over-treatment, ensuring optimal results without unwanted side effects. Always refer to the latest recommendations and consider factors like muscle size and condition severity before determining the dosage.

Factors Influencing Dosage Calculations

The correct Xeomin dosage depends on the patient’s needs, condition severity, muscle size, and age. Different amounts are required for treatments for conditions like frown lines and cervical dystonia. Doctors also consider the patient’s response to previous treatments and adhere to safety guidelines to ensure optimal results without over- or under-treatment.

Avoiding Under or Overdosage

Getting the right Xeomin dose is key. Too much could cause harm, and too little might not work well. Doctors need to figure out how much to use for different problems, like cervical dystonia or frown lines. They look at things like the patient’s size and health condition. It’s also important for them to follow Xeomin guidelines closely.

Doctors must toss out any Xeomin left in the fridge after 24 hours. This rule helps medical professionals avoid using old or unsafe doses on patients. By following these steps, medical professionals can give safe and effective care.

Storage Conditions and Shelf-Life Considerations

Proper storage of Xeomin after reconstitution is essential for maintaining its potency and safety. Check the expiration date on the vial before use, and store unopened vials in a cool place below 30°C. Once mixed, use Xeomin within 24 hours and store it in a refrigerator at 2 – 8°C. Each vial is for one patient only, and any unused portion must be discarded after 24 hours. 

Mark the time of reconstitution and dispose of any remaining product properly. Cold storage ensures Xeomin’s stability and effectiveness, reducing the risk of bacterial contamination and ensuring reliable treatment outcomes for conditions like cervical dystonia or frown lines.

Proper Injection Techniques and Administration Protocols

Giving Xeomin the right way makes a big difference. Learning where and how to inject can help patients feel better with fewer problems. It ensures both safety and the best results. Here are some best practices for picking the injection site:

  • Know Your Target: Always aim for the muscle group or area that needs treatment. For frown lines, focus on the muscles between the brows.
  • Understand Patient Anatomy: Each person’s face and muscle structure are different. Adapt your approach by studying their unique features.
  • Consider Condition Specifics:  The right spot varies with conditions. For cervical dystonia, muscles in the neck or shoulders might be the focus.
  • Avoid Sensitive Areas: Clear regions with a high risk of bruising or major blood vessels.
  • Use Precision: A careful approach means better outcomes and less discomfort.
  • Stay informed about facial nerves: Avoiding them reduces the risk of unwanted effects.
  • Tailor to Treatment History: Previous treatments can affect where you inject next. Noting past sites and responses helps plan future sessions.
  • Keep Comfort in Mind: Some areas might be less painful for injections, improving the patients’ experience.
  • Follow Guidelines: Follow official recommendations and training on injection techniques and sites.

Administering Xeomin Safely and Effectively

Administering Xeomin correctly is key to achieving the desired outcomes for patients. It’s all about using the right techniques and following safety protocols. Here’s how medical professionals can ensure they’re administering Xeomin efficiently:

  • Check patient history and allergies. Knowing past reactions to Xeomin or similar treatments is crucial before any procedure.
  • Use a new Xeomin vial for each session. Guidelines mandate single-use to prevent contamination risk.
  • Reconstitute Xeomin per Merz Aesthetics’ instructions to maintain its effectiveness.
  • Calculate dosage accurately based on the indication—dosage varies for cervical dystonia, frown lines, under-eye bags, or masseter issues.
  • Store reconstituted Xeomin in a fridge at 2-8°C. Use within 24 hours to minimize bacterial risk.
  • Select injection sites precisely for treatment areas like under the eyes or jawline to avoid adverse effects.
  • Adjust injection depth based on the target muscle or treated area for optimal effectiveness.
  • Proceed with injections using a sterile technique to prevent infections and complications.

Managing Potential Adverse Reactions

Ensuring patient safety post-Xeomin injections requires understanding and managing potential side effects like swelling, redness, bruising, headache, and muscle weakness. Educating patients about these reactions and special indications for Xeomin is crucial for optimal treatment outcomes. 

Cold packs and arnica cream can help alleviate discomfort. Provide post-injection care instructions, advise against heavy workouts initially, and schedule a follow-up appointment for assessment, offering contact information for any concerns.


Understanding the reconstitution process, dosage calculations, storage considerations, proper injection techniques, and management of adverse reactions is essential for practitioners utilizing Xeomin in clinical practice. By following these guidelines, practitioners can optimize treatment outcomes and ensure the safe and effective use of reconstituted Xeomin for various indications.


1. How long does Xeomin last after reconstitution?

Once reconstituted, Xeomin starts working on issues like frown lines and under-eye bags within a few days of treatment. However, its effects are not permanent. Xeomin typically lasts 3 to 6 months.

2. Where should I store reconstituted Xeomin?

After reconstitution, store Xeomin in the refrigerator to maintain its stability. Refrigeration helps preserve the molecule’s integrity until it’s ready to use.

3. Can Xeomin be used for areas other than the forehead?

Absolutely! While FDA-approved for treating frown lines, Xeomin is also effective for under-eye bags and shaping the masseter muscle for jawline contouring.

4. Is there any special post-treatment care required after Xeomin injections?

Post-Xeomin care is straightforward. Follow your doctor’s advice closely, including avoiding strenuous activities immediately after treatment and maintaining an upright position. These measures help ensure optimal results.


American Society of Plastic Surgeons. The American Society of Plastic Surgeons ® Procedural Statistics Data Insights Partners: 2022 ASPS Procedural Statistics Release.; 2023. https://www.plasticsurgery.org/documents/News/Statistics/2022/plastic-surgery-statistics-report-2022.pdf

Surgeons AS of P. American Society of Plastic Surgeons Reveals 2022’s Most Sought-After Procedures. www.prnewswire.com. https://www.prnewswire.com/news-releases/american-society-of-plastic-surgeons-reveals-2022s-most-sought-after-procedures-301938919.html



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