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Wegovy Side Effects – Listing Rare and Common

David Fuller

Last Updated On: July 5, 2024

Type 2 diabetes, a chronic condition characterized by insulin resistance, affects millions worldwide. Medications play a crucial role in managing blood sugar levels. From metformin to sulfonylureas, these drugs offer diverse mechanisms to control glucose. 

Wegovy is FDA-approved for chronic weight management and is the latest addition to the list of medications that target obesity and type 2 diabetes. Administered alongside a reduced-calorie diet and increased physical activity, Wegovy helps adults shed excess body weight and maintain it.

This article explores rare and common Wegovy side effects, from thyroid concerns to allergic reactions, empowering patients and healthcare providers.

Key Takeaways

  • Wegovy is a medication used for weight management.
  • Common side effects of Wegovy include nausea, diarrhea, and headache.
  • Rare but serious side effects of Wegovy include pancreatitis and gallbladder issues.
  • Healthcare professionals should monitor and assess patients for side effects and provide intervention strategies.
  • Patient education is crucial for recognizing and reporting side effects and making lifestyle modifications for symptom management.

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Common Side Effects of Wegovy

Wegovy is known for its effectiveness in weight loss. Like all medications, it comes with side effects that patients may experience.

  • Nausea and Vomiting: Nausea and vomiting are common but manageable side effects at the start of Wegovy therapy. Starting with a low dose and increasing it gradually helps reduce these symptoms. Patients should eat small, frequent meals, stay hydrated, and monitor for dehydration. Clear communication and supportive care, including possible dose adjustments, are crucial for successful treatment and patient comfort. 
  • Diarrhea: Diarrhea can occur as a side effect of Wegovy, affecting some patients. Managing this involves gradual dietary adjustments and maintaining good hydration. Although inconvenient, diarrhea is usually temporary and manageable. This underscores the importance of patient education and support during treatment, ensuring that patients are well-informed and prepared to handle this side effect effectively. Proper guidance can help minimize discomfort and improve overall treatment adherence.
  • Headache: Headaches are a possible side effect of Wegovy and occur in some patients. They can range from mild to moderate and typically lessen over time. Managing headaches involves monitoring their severity and frequency and may require adjustments to the treatment plan. Proper patient support and communication are essential.

Rare but Serious Side Effects of Wegovy

Wegovy can occasionally cause serious side effects that need immediate attention. It’s essential for doctors to inform patients about this risk before starting treatment and to monitor for additional symptoms like fever. 


Pancreatitis, a rare but severe side effect of Wegovy, is marked by severe stomach pain that may spread to the back, worsen after eating, and intensify when lying down. Symptoms can include nausea, fever, and jaundice. Reporting these signs early is crucial, as prompt action can prevent serious issues. 

Wegovy (semaglutide) has been approved by the FDA for chronic weight management. The approval was based on data from the Semaglutide Treatment Effect in People with Obesity (STEP) clinical trial program. In these four 68-week, randomized, double-blind trials, approximately 4,500 participants were involved. 

However, it’s essential to note that acute pancreatitis was observed in patients treated with Wegovy. Monitoring for signs and symptoms of acute pancreatitis, such as persistent severe abdominal pain and vomiting, is crucial for patients using this medication. 

Additionally, real-world evidence from health insurance claims suggests an association between semaglutide (the active ingredient in Wegovy) and pancreatitis, with an incidence rate of approximately 5 cases per 1,000 users.

Gallbladder Issues

Gallbladder issues can sometimes occur with Wegovy, leading to pain or other problems. Severe, persistent stomach pain that worsens after eating might signal pancreatitis, which needs immediate medical attention. If you notice your skin or eyes turning yellow, it could indicate gallbladder trouble. 

In adult patients, 1.6% of Wegovy patients and 0.7% of placebo patients reported cholelithiasis (gallstones), and 0.6% of Wegovy patients and 0.2% of placebo patients reported cholecystitis (inflammation of the gallbladder).

In the real world, recent studies have revealed that prolonged use of Wegovy may significantly increase the risk of developing gallbladder problems, such as gallbladder disease and gallstones. Patients taking Wegovy were more likely to have gallbladder problems, although this side effect was rare in children.

Managing Wegovy Side Effects

For healthcare professionals guiding patients on Wegovy for weight loss, managing side effects is essential. Pay close attention to common issues like nausea, vomiting, diarrhea, and headaches, and encourage patients to report any new or worsening symptoms immediately. Offer practical solutions, such as adjusting their diet or medication schedule, to address these problems. 

Suggest eating smaller, more frequent meals to help with stomach issues and emphasize the importance of rest and hydration to combat headaches and fatigue. Regularly review how patients use the Wegovy pen to ensure proper use and share success stories to maintain motivation and morale.

Guidelines for Healthcare Professionals

Monitoring and assessing patients on Wegovy is crucial for healthcare professionals. It helps detect side effects early and ensures the treatment is working effectively.

  • Schedule Regular Check-ups: Track progress and detect side effects early.
  • Teach Proper Pen Use: Prevent malfunction and dosing errors.
  • Compare Effectiveness: Review patient records for Wegovy vs. Mounjaro and Zepbound.
  • Check Weight Loss Milestones: Adjust treatment as needed.
  • Monitor Common Side Effects: Nausea, vomiting, diarrhea, and headaches; adjust therapy if necessary.
  • Educate on Serious Side Effects: Recognize and report pancreatitis or gallbladder issues immediately.
  • Use Clinical Trial Data: Assess the risk of rare symptoms in patient evaluations.
  • Review Case Studies: Inform monitoring strategies for pancreatitis and gallbladder problems.
  • Encourage Lifestyle Changes: Support symptom management and overall health.

Tips for Patient Education

Doctors and nurses should educate patients about Wegovy’s prescribing information and its side effects and encourage them to report unusual symptoms. It is crucial for safety to recognize serious issues like pancreatitis or gallbladder problems and seek prompt medical attention.

Lifestyle Modifications for Symptom Management

Lifestyle changes can help patients on Wegovy manage side effects. These adjustments are crucial for comfort and overall health.

  • Stay hydrated: Drink water to avoid dehydration.
  • Eat small meals: Bland foods like crackers can help with nausea.
  • Add fiber slowly: Helps with bowel movements.
  • Exercise gently: Improves digestion and reduces headaches.
  • Manage stress: Use deep breathing or meditation.
  • Keep a diary: Track symptoms to identify triggers.
  • Consult provider: Adjust Wegovy dose timing if needed.
  • Include carbs: Maintain steady blood sugar.
  • Monitor symptoms: Work with healthcare professionals to adjust treatment.


Wegovy comes with its own set of side effects, both common and rare. Knowing these can help you manage them better. From nausea to more serious conditions like pancreatitis, being informed is critical. If symptoms show up, talking to a healthcare provider quickly helps a lot. Staying educated on Wegovy’s effects makes treatment smoother for everyone involved.


1. What is Wegovy, and how does it work? 

Wegovy, or semaglutide, is a weight loss medication that mimics a hormone-regulating appetite to manage weight.

2. What are the common side effects of Wegovy? 

Common side effects of Wegovy include nausea and diarrhea, which typically lessen as the body adjusts to the medication.

3. Are there any rare side effects of Wegovy? 

Rare side effects of Wegovy may include severe kidney problems or mood changes such as depression and suicidal thoughts. Contact your doctor if you experience any unusual symptoms.


MSN. www.msn.com. https://www.msn.com/en-us/health/condition/Type-2-diabetes/hp-Type-2-diabetes?source=conditioncdx

Wegovy Side Effects: What They Are and How to Manage Them. Healthline. Published February 4, 2023. https://www.healthline.com/health/drugs/wegovy-side-effects 



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