Business Hours: Monday-Friday 9AM-6PM EST

Featured Image

Supartz vs Euflexxa: Comparison of Hyaluronic Acid Treatments

David Fuller

Last Updated On: June 20, 2024

Recent studies show that hyaluronic acid (HA) injections effectively manage knee osteoarthritis (OA), offering symptomatic relief and improving joint function. A systematic review comparing HA treatments for knee OA shows that high-molecular-weight HAs, such as Supartz and Euflexxa, demonstrate favorable efficacy and cost-effectiveness compared to low-molecular-weight options.

Supartz and Euflexxa provide viscosupplementation to the knee joint to restore its natural lubricating and shock-absorbing properties. These injections offer an alternative for patients who have not responded to other conservative treatments and are hesitant to undergo surgery.

This article will explore the similarities and differences between Supartz and Euflexxa, including their mechanisms of action, treatment regimens, efficacy, and safety profiles.

Key Takeaways

  • Supartz and Euflexxa are hyaluronic acid-based therapies used to treat osteoarthritis.
  • Both treatments have similar mechanisms of action but differ in their formulations and indications for use.
  • Clinical trial data suggests that both Supartz and Euflexxa effectively reduce pain and improve function in patients with knee osteoarthritis.
  • Common side effects of both treatments include injection site pain and swelling, while severe but rare adverse events may occur.
  • Cost considerations and insurance coverage may influence the choice between Supartz and Euflexxa for osteoarthritis treatment.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. Buy Supartz online at Med Supply Solutions today and stock your practice at wholesale prices!

Introduction to Supartz and Euflexxa

Knee pain from osteoarthritis can significantly impact daily life, making effective treatment crucial. Supartz and Euflexxa are two hyaluronic acid-based options designed to alleviate this pain. This article compares their effectiveness, cost, patient satisfaction, and treatment protocols. While Supartz may require up to five injections, Euflexxa typically only needs three, significantly influencing treatment choice.

Studies suggest that Supartz may delay the need for knee replacement surgery longer than Synvisc. Ongoing research aims to determine which treatment offers the most benefits with the least risk and cost. Safety remains paramount, and multiple rounds of Supartz injections pose no additional risk compared to a single round.

Osteoarthritis and Hyaluronic Acid-based Treatments

Osteoarthritis, a joint disease causing pain and stiffness, often affects the knees, challenging daily activities. Hyaluronic acid, a natural shock absorber, decreases osteoarthritis, worsening joint problems. Studies show that patients treated with Supartz/Hyalgan, Euflexxa, and Orthovisc experience longer delays in total knee replacement than those treated with Synvisc.

Hyaluronic acid-based therapies like Supartz and Euflexxa injections offer a modern approach to treating knee osteoarthritis. These treatments mimic the natural joint fluid, aiming to reduce pain and improve joint function without surgery. While each product has a unique formula, their shared purpose is to ease joint pain. 

Supartz and Euflexxa differ in dosing schedules; Supartz may require up to five injections, whereas Euflexxa typically involves three. Their effectiveness varies, with some studies suggesting specific hyaluronic acid formulations might be more effective at relieving pain or improving mobility. 

Formulation and Mechanism of Action

Supartz and Euflexxa are treatments for knee osteoarthritis. They feature hyaluronic acid as their main component. They differ in structure and treatment approach, catering to different patient needs.

  • Supartz is made from a purified form of hyaluronic acid. This comes from rooster combs, which are natural sources. Patients receive this through injections directly into the knee joint.
  • Euflexxa, on the other hand, boasts a bioengineered form of hyaluronic acid. It does not come from animal sources, making it a choice for people who prefer non-animal-based treatments.
  • Both treatments work by mimicking the body’s hyaluronic acid. This substance lubricates and cushions the joint, easing pain.
  • The Supartz formula allows for a series of injections. Typically, patients might need up to five injections for full benefits.
  • Euflexxa’s regimen usually involves three injections over several weeks. This schedule can be more convenient and cost-effective for some patients.

Indications for Use

Supartz and Euflexxa treat knee osteoarthritis but have different approved indications. Learning about their uses can help us understand which treatment might suit specific patient profiles. While these treatments are generally safe, Supartz’s side effects may cause discomfort at the injection site or mild swelling. It’s important to discuss potential side effects with your doctor before undergoing treatment.

Efficacy and Clinical Evidence

Evaluating how well Supartz and Euflexxa work is essential. Research data for both treatments will be examined to compare their effectiveness, guiding medical professionals in making informed decisions.

Clinical Trial Data for Supartz and Euflexxa

Both Supartz and Euflexxa have shown promising results in clinical trials for knee osteoarthritis. A study comparing different hyaluronic acid treatments found that patients treated with Supartz injections experienced significant pain relief and improved joint function. 

Multiple courses of Supartz injections are as safe, if not safer, than the initial course. Similarly, patients receiving Euflexxa injections reported reduced pain and improved function, indicating its positive impact on managing knee osteoarthritis symptoms.

Comparison of Efficacy Between the Two Treatments

When comparing the efficacy of Supartz and Euflexxa, medical professionals consider several factors to determine which hyaluronic acid treatment offers better outcomes for knee osteoarthritis patients. The following provides a summarized comparison of clinical trial data and the effectiveness of both treatments.

Delay to Total Knee ReplacementPatients had longer delays compared to Synvisc, and similar outcomes were expected with EuflexxaComparable delays in knee replacement to Supartz
Average RatingWith different dosing processes, ratings vary6.1 out of 10
Safety on Repeated UsePossibly safer than the first courseNot explicitly mentioned, but ongoing research suggests similar safety profiles.
Rheological PropertiesVarying structuresLinear chain structures and cross-linked differences noted
Cost for PatientsFive injection processes might imply higher costsThree injection process may be more cost-effective
Efficacy in Pain Relief and FunctionEffective; however, intra-articular PRP injection showed more efficacy in some studies.Effective studies suggest similar outcomes to Supartz with variations in individual response.

Safety and Side Effects

Supartz and Euflexxa are generally safe treatments for knee osteoarthritis. However, like any medical procedure, they may cause side effects. Let’s explore their safety profiles and potential side effects.

Common Side Effects of Supartz

  • Mild pain or swelling at the injection site.
  • Minor joint stiffness or warmth after the injection.
  • Rare cases of redness, itching, or rash at the injection site.
  • Occasional headaches or dizziness after receiving the injections.
  • Infrequent instances of nausea or stomach upset.

These side effects are typically mild and transient, resolving independently without intervention. If patients experience severe or persistent symptoms, they should seek medical attention promptly to rule out any complications.

Common Side Effects of Euflexxa

  • Injection Site Pain and Swelling: Pain and swelling are often temporary and usually resolve independently.
  • Joint Stiffness: Some patients may experience stiffness in the treated joint after receiving Euflexxa injections.
  • Itching or Skin Irritation at the Injection Site: Mild itching or skin irritation may occur at the injection site.

These side effects are generally mild and tend to improve as the treatment progresses.

Cost Considerations

When considering cost, it’s essential to carefully evaluate the financial implications of both Supartz and Euflexxa treatments. An in-depth understanding of insurance coverage and reimbursement considerations can significantly impact the overall cost for patients.

Insurance Coverage and Reimbursement Considerations for Both Treatments

Insurance coverage and reimbursement for Supartz and Euflexxa vary. While some insurance plans cover both treatments, the extent of coverage depends on individual policies. Patients may need prior authorization or meet specific criteria for coverage approval. Factors such as deductibles and co-pays also influence treatment costs.

Healthcare providers must guide patients through insurance complexities, ensuring they understand their financial responsibilities. Both treatments have billing codes for claim submission, and providers should stay updated on coding requirements and payer policies to facilitate timely reimbursement.


Supartz and Euflexxa are valuable options for managing knee osteoarthritis, offering patients the potential for pain relief and improved joint function. While both treatments share similarities in their mechanisms of action and safety profiles, differences in formulation, indications, and cost may influence the choice. Doctors should carefully evaluate individual patient needs and preferences when considering Supartz or Euflexxa for the treatment of knee osteoarthritis.


1. What is the difference between Supartz and Euflexxa?

Both Supartz and Euflexxa are hyaluronic acid treatments designed to alleviate knee pain. However, they have distinct mechanisms of action. While both treatments aim to ease pain, they may work differently in the body to achieve this goal.

2. Are there any side effects associated with Supartz injections?

Yes, some individuals may experience side effects from Supartz injections, although they are not very common. These side effects may include discomfort at the injection site or mild swelling. It is important to discuss potential side effects with your doctor before undergoing treatment.

3. How frequently are Supartz injections administered?

Supartz treatment typically consists of a series of injections, similar to episodes in a series. Patients may receive up to five injections over several weeks. The treatment schedule is tailored to meet the specific needs of each individual’s knee.

4. Why should I choose Supartz over Euflexxa?

The choice between Supartz and Euflexxa depends on individual preferences and medical advice. Some patients may find one treatment more suitable for them based on their reaction to the treatment or their doctor’s recommendation after considering factors such as reviews and potential side effects.


Aponte J, Nokes KM. Electronic health literacy of older Hispanics with diabetes. Health Promot Int. 2017;32(3):482–489. doi:10.1093/heapro/dav112

How Supartz Injections Are Used to Relieve Knee Osteoarthritis. Verywell Health. Accessed May 10, 2024. https://www.verywellhealth.com/what-is-supartz-190466 



Log In


Subscribe for exclusive offers and updates on new arrivals




Share feedback at:

[email protected]

Working Hours

Monday to Friday: 9 AM to 6 PM (EST)

The Most Popular Brands

Copyright 2024. Med Supply Solutions