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Radiesse Ingredients: What Goes in This Dermal Filler?

David Fuller

Last Updated On: June 22, 2024

Did you know that over 3 million people receive dermal filler treatments in the United States every year? This significant number underscores their popularity as cosmetic treatments. They effectively plump wrinkles, smooth lines, and restore facial volume. They offer a minimally invasive solution for enhancing a person’s youthful look.

Radiesse stands out for its unique composition and longevity among the available fillers. An injectable filler that can provide immediate volume stimulates the body’s natural collagen production for sustained results. This seamless blend of immediate and long-term benefits makes Radiesse a compelling choice for addressing facial volume loss and wrinkle reduction.

In this article, we will explore Radiesse’s ingredients, composition, and the mechanisms that allow it to revitalize the skin.

Key Takeaways

  • Radiesse is a dermal filler with calcium hydroxyapatite as its primary ingredient. It is known for its volumizing and collagen-stimulating effects.
  • The interaction of calcium hydroxyapatite with the body’s tissues plays a crucial role in achieving the desired aesthetic outcomes.
  • Understanding Radiesse’s composition and mechanisms of action is essential for optimizing patient outcomes and making informed clinical decisions.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to buy Radiesse online, contact our sales department for more information.

Composition of Radiesse

Radiesse is a dermal filler renowned for its unique composition. It blends calcium hydroxyapatite with other safe ingredients to effectively address signs of aging. Making up 30% of its composition, Radiesse contains calcium hydroxide, miming components found in bones and teeth, ensuring safety and compatibility with the body. Notably, its biodegradable nature and compatibility with the body underscore its efficacy in cosmetic enhancements.

What distinguishes Radiesse is its dual-action mechanism. It instantly fills wrinkles and stimulates collagen production, ensuring long-term skin rejuvenation. This dual action provides natural-looking, long-lasting results, making Radiesse a preferred choice for those seeking immediate rejuvenation without repeated treatments.

Other Components of Radiesse

Radiesse does more than fill wrinkles. It helps your skin rebuild natural collagen. Here is a look at other ingredients in Radiesse:

  • Aqueous Gel Carrier: This part makes up about 70% of Radiesse. It’s mostly water and glycerin. The gel helps deliver the calcium hydroxylapatite smoothly into your skin.
  • Glycerin: An ingredient in the gel carrier, glycerin keeps the skin hydrated and helps ensure the treatment spreads evenly.
  • Sodium Carboxymethylcellulose: This ingredient helps to thicken the gel. It makes sure Radiesse stays where doctors put it.
  • Phosphate-buffered Saline: This ingredient is salty water that matches your body’s fluid levels. It helps mix all ingredients well and keeps them safe for your body.

Mechanisms of Action

Radiesse stimulates collagen production, offering long-lasting rejuvenation. Its main ingredient, Calcium Hydroxyapatite, is a scaffold under the skin, supporting new collagen growth. As the body gradually breaks down the gel carrier, the calcium particles in Radiesse remain, rejuvenating the skin and ensuring long-lasting results.

Like planting seeds in a garden, this process initiates ongoing collagen production, resulting in youthful, refreshed skin for over a year post-injection. Calcium hydroxyapatite’s compatibility with the body ensures gentle yet effective treatment, minimizing swelling and side effects. Radiesse’s unique ability to stimulate collagen production sets it apart, offering patients natural-looking, long-lasting results without frequent touch-ups.

Duration of Action

The effects of Radiesse last a long time. After just one injection, it keeps working for a year or more. This longevity is due to the calcium hydroxylapatite in Radiesse, which helps make more collagen. More collagen means skin looks young and smooth for longer. 

Over time, the body naturally breaks down and absorbs Radiesse. Yet, its ability to boost collagen production has lasting benefits on skin texture and firmness. 

How the Composition Influences the Longevity of Results

Radiesse’s mix is vital for long-term improvements. Calcium hydroxyapatite is safe for the body and matches the stuff in bones and teeth. It fills wrinkles right away and helps make more collagen. One shot can keep skin looking better for over a year. 

Other fillers might fade faster, but Radiesse works differently. Its unique parts help your skin build its support system over time. As the gel part goes away, the microspheres stay put, ensuring results last long even as the body slowly breaks and absorbs them.

Factors Affecting the Breakdown and Absorption of Radiesse

Radiesse is a unique filler that lasts longer because of its particular mix. Understanding what affects its breakdown and absorption helps us use it better. Here are essential factors:

  • Patient’s Age: Older skin breaks down Radiesse slower due to less active collagen production.
  • Skin Type: Thicker skin tends to hold Radiesse longer than thinner skin.
  • Injection Area – Places on the face with more movement might see Radiesse breaking down faster. Read our article on Radiesse neck treatment.
  • Individual Metabolism: Some people naturally break down substances faster than others.
  • Quality of Injection Technique: Expert application can influence how well Radiesse integrates with the tissue.
  • Patient’s Lifestyle: Activities like smoking or lots of sun can speed up the breakdown process.
  • Overall Health: A healthier body might maintain Radiesse effects for longer.

Clinical Applications and Suitability

Radiesse works well to make the face and hands look younger. It is suitable for many people, regardless of age or skin type.

  • Smoothing Moderate to Severe Facial Wrinkles: The critical ingredient, calcium hydroxylapatite, works well to fill deep lines, especially around the mouth and nose.
  • Enhancing Facial Contours: Doctors use Radiesse to sculpt facial features. It adds volume and shape to areas like the cheeks and jawline.
  • Hand Rejuvenation: Radiesse is not just for faces; It helps make hands look younger by reducing wrinkles and adding volume.
  • Nasolabial Folds Correction: Do you have deep smile lines around your mouth? Radiesse smooths them out for a more youthful appearance.
  • Chin Reshaping: For patients wanting a more defined chin without surgery, Radiesse offers a non-surgical solution.
  • Improving Skin Texture: Beyond filling wrinkles, Radiesse stimulates collagen production, improving skin quality.
  • Treatment of Marionette Lines: This filler quickly perks up the corners of the mouth, which can sag with age.
  • Non-Surgical Nose Job: Some patients choose Radiesse for minor adjustments to their nose shape without going under the knife.
  • Jawline Definition:  A sharper jawline can be achieved by carefully placing this filler along the mandible.
  • Cheek Enhancement: To restore or add volume to cheeks, giving a lifted look and enhancing facial symmetry.

Considerations for Patients with Specific Medical Conditions

Patients with certain health conditions require careful evaluation before undergoing Radiesse treatments. Those with bleeding disorders or taking blood-thinning medications may have higher risks of bruising and bleeding at the injection site. 

Evaluation is essential for individuals with active skin infections or inflammation nearby to prevent infection spread. Patients with severe allergies or a history of anaphylaxis should disclose their medical history to their healthcare provider to avoid adverse reactions. 

Additionally, those with autoimmune disorders should discuss the benefits and risks of Radiesse thoroughly with their doctor. These assessments ensure safe, personalized care tailored to each patient’s health needs and aesthetic goals.


Understanding the composition and mechanisms of action of Radiesse is crucial for medical professionals to make informed decisions regarding its clinical use. The unique properties of calcium hydroxyapatite and its interaction with the body’s tissues play a significant role in achieving the desired volumizing and collagen-stimulating effects.

By comprehensively understanding the science behind Radiesse, practitioners can optimize patient outcomes and ensure the safe and effective use of this advanced dermal filler.


1. What is Radiesse made of?

Radiesse is made of calcium hydroxylapatite (CaHA) microspheres suspended in a gel carrier.

2. How does Radiesse work?

Radiesse immediately adds volume to the skin and stimulates the body’s natural collagen production.

3. How long does Radiesse last?

Radiesse can last up to a year or more, providing long-lasting results.

4. Are there any side effects of Radiesse?

Common side effects include swelling, bruising, or redness at the injection site, which usually resolves within a few days.


American Society of Plastic Surgeons. 2020 Plastic Surgery Statistics Report. https://www.plasticsurgery.org/documents/News/Statistics/2020/plastic-surgery-statistics-report-2020.pdf

Enrico Massidda. Starting Point for Protocols on the Use of Hyperdiluted Calcium Hydroxylapatite (Radiesse®) for Optimizing Age-Related Biostimulation and Rejuvenation of Face, Neck, Décolletage, and Hands: A Case Series Report. Clinical, Cosmetic, and Investigational Dermatology. 2023;Volume 16:3427-3439. doi:https://doi.org/10.2147/ccid.s420068

Amselem Belilty M. Radiesse®: a novel rejuvenation treatment for the upper arms. Clinical, Cosmetic, and Investigational Dermatology. Published online December 2015:9. doi:https://doi.org/10.2147/ccid.s93137 



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