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Radiesse and Collagen: Stimulating Creation

David Fuller

Last Updated On: June 20, 2024

Did you know that collagen is the protein that provides structural support to our skin? This essential protein keeps the skin looking plump and youthful. However, our bodies naturally produce less collagen as we age, leading to wrinkles and sagging skin.

Radiesse offers a unique solution to this age-related concern. This dermal filler uses a powerful formulation that delivers healthy, younger-looking skin. Various studies have also proven that Radiesse’s ingredients provide immediate volume correction while stimulating the body’s collagen production.

In this article, we’ll explore the science behind Radiesse’s innovative formula and how they combat the visible signs of aging by promoting collagen production.

Key Takeaways

  • Radiesse, a popular dermal filler, comprises calcium hydroxylapatite (CaHA) microspheres suspended in a gel carrier.
  • The presence of CaHA microspheres triggers the body’s natural collagen production, leading to increased skin firmness and elasticity.
  • While the gel carrier provides immediate volume, the collagen stimulated by CaHA microspheres ensures the longevity of Radiesse’s effects.
  • Radiesse’s collagen-stimulating properties help achieve a natural look and feel.
  • Radiesse’s collagen-inducing mechanism makes it an effective and safe option for restoring volume and correcting wrinkles.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to buy Radiesse online, contact our sales department for more information.

The Science Behind Radiesse Collagen Stimulation

Radiesse stimulates your skin’s natural collagen production, helping to smooth wrinkles and rejuvenate your appearance. Our skin produces less collagen as we age, leading to a loss of firmness and elasticity. Radiesse contains Calcium Hydroxylapatite (CaHA) particles, which act as a catalyst, prompting your skin to produce more collagen.

Unlike other fillers, Radiesse provides immediate results and encourages your skin to create its natural filler over time. After injection, the CaHA particles generate a scaffold for new collagen growth, improving skin texture and firmness.

This unique action distinguishes Radiesse from other fillers. It provides immediate contouring and stimulates the production of new collagen and elastin. Studies have shown that Radiesse can create a more robust skin structure lasting over a year, resulting in firmer, smoother skin.

Clinical Evidence and Case Studies

Studies and real-life experiences confirm Radiesse’s effectiveness in stimulating collagen production, resulting in visibly younger-looking skin. Clinical research demonstrates a significant increase in collagen levels over nine months with Radiesse, thanks to its Calcium Hydroxylapatite formula.

Radiesse offers immediate contouring and long-term skin rejuvenation, making it unique among FDA-approved fillers. Patients experience reduced wrinkles and firmer, more youthful skin that lasts over a year after treatment. This result aligns with the FDA’s approval for correcting facial wrinkles and folds, highlighting Radiesse’s efficacy and safety.

Real World Case Examples of Collagen Enhancement with Radiesse

Image courtesy of Vivida Dermatology

This treatment effectively corrects volume deficits under the eyes, as seen in the image, providing natural facial shaping and reducing signs of aging for the patient.

Image courtesy of Shape Medical Center

Notice this patient’s remarkable improvement in skin laxity and discreet volume gain eight weeks after a Radiesse injection. The treatment involved 1ml CaHA (Radiesse) diluted with 1.5mL lidocaine, administered in two sessions at a 4-week interval.

Strategies for Maximizing Collagen-Stimulating Effects

Portrait of a Beautiful Asian woman with skin care, healthy hair, and skin close-up face beauty isolated over the background. Cosmetology and Spa concept.

To get the most out of Radiesse for boosting collagen, it’s all about how and when you use it. Pairing Radiesse with other treatments can also make a big difference in skin health, ensuring optimal results and long-lasting benefits. Your healthcare provider can recommend the best combination of treatments for your unique needs and goals. One of the best use cases is Radiesse as a hand filler. Read our article to find out more.

Injection Techniques for Optimal Collagen Stimulation

Optimal collagen stimulation through Radiesse injections hinges on precise techniques. Medical professionals can enhance patient outcomes by following these strategies.

  • Use a smaller needle for comfort and less bruising.
  • Use linear threading for deep wrinkles and folds.
  • Apply a fanning method for broader areas needing volume.
  • Consider cross-hatching for significant collagen stimulation.
  • Implement subdermal injections to avoid lumpiness.
  • Inject slowly for precise contouring and less discomfort.
  • Massage the area post-injection for even distribution.
  • Stay updated on injection techniques through training sessions.

Treatment Protocols for Long-Term Collagen Enhancement

Radiesse treatments have shown great promise in enhancing collagen for more youthful skin. Medical professionals can maximize these effects with specific treatment protocols.

  • Start with a thorough skin assessment, considering wrinkle depth, skin quality, and areas needing volume. 
  • Aside from a physical assessment, healthcare professionals can also talk with their patients in-depth. They can explain how these fillers work, compare Radiesse fillers vs Sculptra if patients want more options, and address concerns about the procedure.
  • Choose FDA-approved Radiesse to correct facial wrinkles and folds, including nasolabial folds.
  • Plan treatment schedule; one injection stimulates collagen production for a year or longer.
  • Use precise injection techniques to target areas effectively without overfilling.
  • Schedule follow-up visits after initial treatment to assess results and determine if additional injections are needed.
  • Combine Radiesse with other treatments like laser therapy to further boost collagen production.
  • Educate patients on skin care routines, including sunscreen use and hydration, to support collagen health.
  • Monitor progress with before-and-after photos to evaluate long-term outcomes.
  • Keep detailed records of treatment areas and amounts for better results in future sessions.

Combination Therapies to Enhance Collagen Production

Combining Radiesse with laser therapy or microneedling enhances collagen production. Radiesse lays the foundation for new collagen, while additional therapies stimulate skin further. Pairing Radiesse with specific skincare products maintains skin health post-treatment, maximizing rejuvenation benefits.

Empowering Practitioners for Enhanced Patient Results

Giving doctors the right tools and knowledge can up their game in helping patients. It’s all about sharing intelligent tips and solid proof to ensure they see great treatment results.

Doctors see better results with Radiesse because it does more than just fill lines. It wakes up the skin’s collagen to rebuild and refresh. Studies show this filler goes to work, bringing back elastin and collagen, making skin look young and fresh over nine months.

Practical tips serve as a guide for medical professionals, helping them optimize treatment outcomes for their patients. They learn where to inject for the most natural look and how often treatments should occur without going overboard. This advice helps patients see fundamental changes in their skin from a treatment that keeps working long after leaving the clinic.

Practical Recommendations for Long-Lasting Results

Radiesse treatments offer a unique way to boost collagen, giving patients smoother and more youthful skin. Here are some tips for medical professionals on how to get the best long-lasting results.

  • Choose the Right Candidate: Look for patients with moderate to severe facial wrinkles who could benefit from subdermal implantation.
  • Master Injection Techniques: Practice precise injection skills to place Radiesse at the correct depth for optimal collagen stimulation.
  • Follow Recommended Dosages: Adhere to dosing guidelines for precise treatment planning, even though their purposes differ.
  • Schedule Follow-up Treatments: Plan periodic assessments and touch-ups as necessary to extend the filler’s benefits.
  • Combine Therapies Wisely: Radiesse can be used with other treatments, such as laser therapy or microneedling, to enhance overall collagen production.
  • Educate Your Patients: Make sure they know about potential side effects and the importance of post-treatment care. 
  • Stay Updated on Best Practices: Keep learning about new research and techniques in collagen stimulation for continuous improvement in patient outcomes.
  • Document Results Meticulously: Take before-and-after photos to monitor progress and adjust treatment plans as needed.


Radiesse fillers play a pivotal role in collagen stimulation, offering immediate volumization and long-term improvements in skin quality. By understanding the mechanisms of collagen production, leveraging evidence-based strategies, and empowering patients, practitioners can achieve enhanced and long-lasting results, ultimately elevating patient satisfaction and practice success.


1. How does Radiesse stimulate collagen production?

Radiesse contains Calcium Hydroxylapatite (CaHA) microspheres, which act as a scaffold for new collagen growth and stimulate collagen production in the skin.

2. What is the advantage of Radiesse’s collagen-stimulating properties?

Unlike temporary fillers, Radiesse’s collagen-stimulating effect provides long-lasting results, enhancing skin volume and firmness over time.

3. How long does it take to see the collagen-stimulating effects of Radiesse?

While immediate results are visible after injection, Radiesse’s collagen-stimulating effects continue over several months, resulting in gradual skin rejuvenation.

4. Can Radiesse be combined with other treatments to boost collagen production further?

Radiesse can be combined with laser therapy or microneedling to enhance collagen production and maximize skin rejuvenation.


Harvard T.H. Chan. Collagen. The Nutrition Source. Published May 26, 2021. https://www.hsph.harvard.edu/nutritionsource/collagen/

Shino Bay Aguilera, McCarthy A, Saami Khalifian, Z. Paul Lorenc, Goldie K, W. Gregory Chernoff. The Role of Calcium Hydroxylapatite (Radiesse) as a Regenerative Aesthetic Treatment: A Narrative Review. Aesthetic Surgery Journal. 2023;43(10):1063-1090. doi:https://doi.org/10.1093/asj/sjad173



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