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Orthovisc Knee Injections: What to Expect Before, During, and After Treatment

David Fuller

Last Updated On: May 6, 2024

According to the Centers for Disease Control and Prevention (CDC), knee osteoarthritis affects nearly 27 million adults in the United States alone, hindering them from performing their daily activities. Orthovisc knee injections offer a potential solution for these individuals.

These injections contain hyaluronic acid, a substance naturally found in healthy joints that acts as a lubricant and shock absorber. By injecting this solution into the knee joint, Orthovisc aims to improve lubrication and cushioning, potentially reducing pain and stiffness associated with osteoarthritis.

This article explores the Orthovisc treatment process, including pre-treatment consultation, the injection procedure, potential side effects, and recovery tips.

Key Takeaways

  • Orthovisc is a knee gel injection that eases osteoarthritis pain. It works like a cushion and lubricant in the knee.
  • You might need three or four shots over weeks. After, many feel less pain for up to six months.
  • Side effects like swelling or pain can happen but often go away quickly. Always follow the doctor’s tips after getting shots.
  • Before injections, talk with your doctor about your health and what you hope the treatment will do.
  • Relief from pain grows over time, so it’s essential to keep patient and have realistic hopes.

Introduction to Orthovisc Knee Injections

With different viscosupplement treatments available, some prospective patients may wonder what Orthovisc is made from. This innovative knee injection is made from hyaluronan, a natural, non-animal substance found in high amounts in joint tissues and the fluid that fills the joints. This substance acts as a lubricant and shock absorber in the joint, helping it function correctly. 

This treatment reduces bone friction and alleviates pain and stiffness in knee osteoarthritis. Injecting Orthovisc into the knee joint enhances joint function by restoring synovial fluid’s natural shock-absorbing properties and improving mobility.

Preparing for Orthovisc Knee Injections

Evaluating patients and reviewing their medical history is essential before giving Orthovisc knee injections. These actions help ensure the treatment fits the patient’s specific needs.

  • Discuss the patient’s knee pain history, including onset, aggravating, and alleviating factors.
  • Check for past treatments, such as pain meds and physical therapy, to understand what has worked.
  • Check the medical history for allergies to bird proteins, feathers, or eggs since Orthovisc contains hyaluronate.
  • Assess the severity of knee osteoarthritis through physical examination and imaging tests to confirm suitability for Orthovisc injections.
  • Discuss current medications to avoid drug interactions with Orthovisc treatment.
  • Advise on potential side effects such as pain, swelling, heat, rash, itching, and bruising.
  • Discuss daily activities and work to understand how knee osteoarthritis affects their life and treatment goals.
  • Finally, ensure they understand the procedure,[particularly how long Orthovisc lasts and what they can expect during each injection visit.

The Orthovisc Injection Procedure

Orthovisc injections are a crucial treatment for pain caused by osteoarthritis in the knee joint. Here’s what medical professionals need to know about the administration technique and injection site for Orthovisc injections.

  • The patient should be comfortable lying down or sitting with a slightly bent knee, ensuring easy access to the injection site.
  • Cleanse the skin over the knee joint thoroughly with an antiseptic solution to prevent infection.
  • Mark the injection site accurately. The typical site is on the medial side of the patella, avoiding any bony prominences or existing scars.
  • Use a fine-gauge needle to minimize discomfort. The treatment involves the use of a pre-filled syringe with Orthovisc.
  • Gently insert the needle into the marked site, ensuring it enters the synovial space of the knee joint.
  • Slowly inject Orthovisc into the knee joint space, taking care not to apply too much pressure, which might cause discomfort or damage.
  • After injecting all of the Orthovisc treatment, carefully remove the needle and apply a sterile bandage over the injection site.

Common Questions and Concerns About the Injection Process

Moving from potential discomforts or side effects during the Orthovisc procedure, many medical professionals and patients have questions and concerns about the injection process. Addressing these can help ensure everyone is well-informed and comfortable with the treatment plan.

  • What does the Orthovisc injection feel like?

Patients might feel a brief pinch or pressure during the needle insertion. Post-injection, there could be temporary discomfort or swelling in the knee area.

  • Are there any side effects I should watch out for?

Common side effects include pain, swelling, heat, rash, itching, and bruising at the injection site. These usually lessen shortly after treatment.

  • How long does each session take?

The injection process is quick, typically taking only a few minutes. However, additional time may be necessary for preparation and observation after the injection.

  • How many injections will I need?

Orthovisc treatment involves three or four injections given one week apart.

  • What should I do after receiving an Orthovisc injection?

Follow your healthcare provider’s post-injection instructions, such as applying ice to reduce swelling and avoiding strenuous activities for a short period.

  • When will I start seeing improvement in my symptoms?

Some patients notice improvement quickly; however, it can vary with each individual’s different response to treatment.

  • How often can I have Orthovisc injections?

If successful, patients may have this treatment again every six months or as advised by their healthcare provider based on their knee’s condition and overall health status.

  • Who is not a good candidate for Orthovisc injections?

Patients with infections or skin diseases around the injection site should avoid this treatment to prevent complications.

Communication between patients and healthcare providers is crucial during Orthovisc knee injections for the best possible outcomes.

Aftercare and Recovery Following Orthovisc Injections

Orthovisc knee gel injections are FDA-approved for reducing knee pain due to osteoarthritis. After the injection, patients might experience some side effects and symptoms.

  • Patients may expect pain at the injection site. It usually fades away after a few days.
  • Swelling might occur around the injection area in the knee. This condition is typically temporary.
  • Patients may feel heat or warmth in the knee joint, indicating a reaction to the Orthovisc injection.
  • Some patients report a rash or itching around the injection area as their skin reacts to the treatment.
  • Bruising may appear where the needle entered, although it should diminish within a week.
  • Discomfort while walking or moving the injected knee could happen but usually lessens as days pass.
  • More intense reactions can occur in rare instances, such as severe pain or swelling that demands immediate medical attention.
  • Set appointments one week after each injection to assess the knee’s response to treatment and adjust care as needed.
  • Track improvements in knee pain and mobility over time, which helps evaluate how well Orthovisc works.
  • If Orthovisc provides good relief, discuss the next steps, whether more injections are an option, or whether patients need other treatments.

Recommendations for pain management and activity modification

After an Orthovisc knee injection, patients may experience discomfort and swelling. They can use ice packs for short periods to alleviate these symptoms and avoid heavy lifting or high-impact exercises. Gentle movements and walking can keep the joint moving without adding stress. 

Following up with a healthcare provider is vital to spot any early side effects. Watch for signs of increased pain, heat, rash, or swelling that doesn’t go away. Regular follow-ups and sticking to a care plan from medical experts are crucial to keeping knees healthy after Orthovisc injections.

Long-Term Effects and Expectations

Orthovisc treatment involves a series of three or four weekly injections, and it’s important to note that pain relief is gradual. Patients should not expect instant relief after the treatment. The real benefits of Orthovisc injections typically begin to show several weeks after the series is completed, with pain relief lasting up to six months afterward. 

However, results vary from person to person. Patients must stay patient and follow post-injection guidelines to achieve the best outcomes. While some may notice improvements sooner than others, focusing on long-term gains rather than short-term setbacks guides better therapy outcomes for everyone involved. 

Orthovisc injections work over time, providing lubrication and cushioning to help reduce knee pain and improve mobility in patients with osteoarthritis who haven’t found relief elsewhere.


With Orthovisc injections, managing knee osteoarthritis becomes more manageable. Understanding the process empowers informed decisions. Healthcare professionals customize treatment plans and follow-up care to optimize outcomes. Orthovisc’s long-term benefits ensure a more comfortable future despite gradual improvement.

About: Since 2016, Med Supply Solutions has established itself as a leading and trusted supplier in the cosmetic and viscosupplementation industry, providing an answer to queries such as “orthovisc treatment.” Known for competitive pricing, we help medical practices boost profitability and maximize resources. Each client receives dedicated VIP sales agent service, ensuring a smooth and comfortable shopping experience. This commitment allows our clients to easily access high-quality products at great prices.


Patient Information ORTHOVISC® High Molecular Weight Hyaluronan. Accessed April 16, 2024. https://www.accessdata.fda.gov/cdrh_docs/pdf3/p030019d.pdf

About Hyaluronate Injections in Your Knee | Memorial Sloan Kettering Cancer Center. www.mskcc.org. Accessed April 16, 2024. https://www.mskcc.org/cancer-care/patient-education/about-hyaluronate-injections-your-knee

ORTHOVISC® | Cal Sports & Orthopaedic Institute | Orthopaedic Specialists in Berkeley, Oakland & Orinda. calsportsortho.com. Accessed April 16, 2024. https://calsportsortho.com/treatments/orthovisc/

Orthovisc: Uses, Dosage, Side Effects, Warnings. Drugs.com. Accessed April 16, 2024. https://www.drugs.com/orthovisc.html



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