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What is the difference between Revanesse Kiss and Restylane Kysse?

David Fuller

Last Updated On: February 29, 2024

Disclaimer: The contents of this article should not be construed as medical advice but only for informational purposes. Medsupplysolutions.com staff does not review any of these articles for medical validity. Medsupplysolutions does not endorse the opinions or views expressed in this article. Please always seek professional medical advice from licensed doctor.

Have you ever wondered why lip fillers are usually separate from other dermal fillers? Among different dermal filler brands, you will most likely find something specific for lips. The main reason for this is because the lips are an especially sensitive area compared to the rest of the face. Think about it. Your lips need to be able to move and not impede your speech or how you eat; it is sensitive to touch and heat; and it is also full of blood vessels which will need a bit more finesse when injecting dermal fillers.

But for all its complications, lip fillers are still a growing part of the medical aesthetic industry. According to the American Society of Plastic Surgeons, There has been a steady increase in lip enhancements. Since the year 2000, there has been more than a 50% increase in interest from patients as young as 18 years old all the way to senior citizens. It’s hardly surprising that many people are interested given the popularity of large pouty lips among celebrities like Angelina Jolie, Kylie Jenner, and others. On top of that, modern lip fillers have become more accessible than ever. Most procedures are quick, safe, and not too expensive with little to no downtime required.

As one of the most popular medical aesthetic procedures available, which lip filler would be the best for you? Let’s compare two of the best-selling lip fillers in the market today: Revanesse Kiss and Restylane Kysse.

Revanesse Kiss

Revanesse Kiss is from the series of Revanesse products produced by Prollenium Medical Technologies, Inc. Revanesse uses its advanced Thixofix cross-linking technology and proprietary formula to produce remarkably homogeneous and long-lasting cross-linked hyaluronic acid. Their technology allows them to make hyaluronic acid molecules that are uniformly spherical that allows for smoother hyaluronic acid that adds volume and degrades slowly. 

A specifically formulated hyaluronic acid gel, Revanesse Kiss is used to accentuate and define the lips and perioral area. Revanesse Kiss is the best product for shaping and adding volume to the lips since the region surrounding the lips has distinct properties. It is specifically indicated for lip augmentation and augmentation of the perioral area, marionette lines, and nasolabial folds.

Revanesse’s smooth and spherical hyaluronic acid molecules help to make lips fuller but with a smoother and more natural look. Since it is made of non-animal hyaluronic acid, it is readily accepted by the body and has very few risks and side effects. However, it is contraindicated in some cases, such as

  • Hypersensitivity to hyaluronic acid
  • Pregnancy or breastfeeding
  • Minor
  • Do not inject into areas with skin problems of an infectious or inflammatory nature.
  • Avoid areas already treated with a permanent filler.

The administration of Revanesse Kiss takes only around 15 minutes and results can be seen almost immediately. Revanesse Kiss can last from six up to nine months depending on the patient’s skin condition, exposure to sunlight, age, and lifestyle.

After Revanesse Kiss is applied, patients must avoid touching or applying pressure to the treatment area for 24 hours. Facial expressions should also be avoided during the first 24 hours. Patients are advised to avoid smoking and alcohol; and applying UV protection with at least SPF 30 every day is recommended to achieve the best results and to prolong the effects of the lip filler.

Restylane Kysse

Restylane Kysse is part of the line of Restylane products being produced by Galderma. Restylane is the breakthrough dermal filler that initially used NASHA or non-animal stabilized hyaluronic acid in their products for higher bio-compatibility and better integration into the skin. Restylane has a wide array of products for different indications and Restylane Kysse is their answer to individuals looking for a natural-looking way of augmenting lips.

Designed specifically for the movement of lips, Restylane Kysse is made with XpresHAn Technology’s innovative cross-linking gel for precise, natural-looking results. Restylane Kysse adds volume, smoothens wrinkles in the perioral area, and improves lip color and texture for up to 9 months. 

One of the advantages of Restylane Kysse is its effectiveness means that a smaller amount of product is needed for effective results compared to other lip fillers. Its XpresHAn technology provides allows more movement and elasticity in the lips compared to other products. It adds volume but keeps up a lip-like feel that is imperceptible compared to natural lips. The results are so natural-looking that 96% of respondents in a study reported that their lips look natural after receiving Restylane Kysse.

The injection procedure for Restylane Kysse starts with a numbing cream applied to the lips. Once its effects have started, Restylane Kysse is injected into the lips in a series of injections with a needle or a blunt-tipped microcannula. During the injection procedure, many patients have reported very minimal discomfort thanks to the numbing agent, but also due to the thinner texture of the gel and lesser amount of product being injected. All in all, most procedures would be completed in about 15 minutes. 

Post-injection, patients would be advised to avoid applying pressure to their lips for the first 24 hours. Some pain and swelling is to be expected and applying ice to the lips is recommended if they feel painful. The swelling should subside over a week and final results should be apparent by then as well. Lips should look and feel fuller but with natural elasticity and users have exhibited more color in their lips than prior to the injection. Lips should also feel smoother and more hydrated thanks to the hyaluronic acid.

Common side effects, though few and very temporary, can include swelling, discoloration, bruising, pain in the treatment area. These symptoms should subside within a few days. To avoid complications, patients are advised against taking NSAIDs and other blood thinning substances for one week to prevent bruising and to use cold compress to manage pain and swelling after the injection. Exposure to extreme temperatures or sunlight can cause temporary redness, swelling, or itching of the injection site so patients are also advised to avoid such for at least 24 hours and it is recommended to use UV protection regularly to help make sure the effects last as long as possible.


Regardless of which lip filler you will choose, make sure to have a thorough discussion with your dermatologist or the injecting physician so that they will be able to answer all your questions and better prepare you for the procedure and what to do after for best results.

Disclaimer: The contents of this article should not be construed as medical advice but only for informational purposes. Medsupplysolutions.com staff does not review any of these articles for medical validity. Medsupplysolutions does not endorse the opinions or views expressed in this article. Please always seek professional medical advice from licensed doctor.



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