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5 most popular brands of Hyaluronic acid injection in 2023

David Fuller

Last Updated On: February 29, 2024

The hyaluronic acid (HA) injections knee protects by reintroducing lost or diminished hyaluronic acid in the knee synovial fluid. The synovial fluid absorbs the daily impact of walking, running, and stair climbing on the knees.

Viscosupplementation is a treatment of Hyaluronic Acid Injections. It increases the “viscosity” or the synovial fluid’s thick, sticky, gel-like properties. Your patients will be interested in these procedures because it helps the joints work properly.

Hyaluronic acid is found naturally in different parts of the body as well as in joints. The joint is located in the cartilage, and the synovial fluid lubricates the joints to keep them working smoothly.

Hyaluronic Acid Injections treat knee and other joint pain caused by osteoarthritis (OA) in patients.

Disease evaluation of osteoarthritis is generally slow and can take years. Successively, the disease can also go through stages or show gradual change over time, causing the severity and symptoms of the condition to worsen.

In people with arthritis, hyaluronic acid gets thinner and can no longer protect the joint. Injections of artificial hyaluronic acid into affected joints may improve protection, similar to a top-up of engine oil. These injections help to move more comfortably in case your patient ages or their knees are exposed to excess weight or physical activity. Furthermore, their cartilage starts to break down, and their synovial fluid becomes thinner. Without this protection, the bones of your patient’s knees rub together, causing inflammation, irritation, and pain.

Benefits and uses of hyaluronic acid injections

Hyaluronic acid injections help relieve the pain caused by osteoarthritis. Some patients find relief from symptoms within a few days. Full advantages usually are reached 3-5 weeks after the treatment. The peak effect is at about eight weeks, and the treatment may provide pain relief for up to 9 months. If successful, the injectable hyaluronic acid can be repeated after 6-9 months.

Hyaluronic acid for joints injection keeps the bones of your patients from scraping. This mechanism used is similar to a lubricant to help decrease inflammation and ease the pain.


Description of the brand: Orthovisc is an injectable, transparent, viscoelastic solution for relieving osteoarthritis (OA) pain. Orthovisc’s main ingredient is ultra-pure, high molecular weight hyaluronic acid (HA), similar to the hyaluronic acid typically found in the synovial fluid of your patient’s joints. Unlike some forms of hyaluronic acid, Orthovisc is made in the lab from bacterial fermentation, not from avian sources, which means it is less likely to cause a reaction when your patient has egg allergies or bird allergies.

Product offerings and variations: It is available in one pack of 3×2 ml Syringes.

Pricing and availability: the cost is $52, and this product is available on our website.


Description of the brand: Supartz is an injectable solution made of sodium hyaluronate used to treat osteoarthritis. This sodium hyaluronate is sourced from rooster combs and is similar to the hyaluronic acid found in the synovial fluid of the human body. Supartz is a viscosupplement that acts as a replacement for the hyaluronic acid that is lost from the joints with age.

Product offerings and variations: It is available in a 10 mg/ml Injection Prefilled Syringe with 2.5 ml

Pricing and availability: the price is $299, and this product is available on our website.


Description of the brand: In cases of osteoarthritis, the piece of natural hyaluronan is reduced, and its quality may be inferior to normal, which causes irritation, inflammation, pain, and immobility in the joints. Monovisc is a gel substance consisting of the maximum hyaluronic acid dose (88 mg). The product adds hyaluronic acid to the joint when injected, where it acts as a lubricant and pain reliever.

Product offerings and variations: It is available in a 1 Syringe x 4 ml per pack

Pricing and availability: the cost is $349, and this product is available on our website.


Description of the brand: The principal component of HYALGAN is a naturally derived hyaluronan that relieves your pain by lubricating and cushioning your knee joint. Hyalgan is an injection solution used in musculoskeletal system pathology, particularly for mild to moderate knee joint arthritis. Hyaluronic acid has an astringent effect on the synovial fluid, which improves joint mobility and relieves pain.

Product offerings and variations: It is available in 2 ml in a glass bottle and 2 ml in a prefilled glass syringe. 


Description of the brand: Euflexxa is an injectable viscosupplement that is used to relieve osteoarthritis knee pain. Euflexxa is made from hyaluronic acid, a natural substance in the knee’s synovial fluid. 

When you inject Euflexxa into your patient’s knee, it replaces the synovial fluid and restores the lubrication and cushioning lost to the knee. It allows them to regain mobility. Your patients would walk without their bones rubbing. 

Product offerings and variations: It is obtainable in 2 ml of 10 mg/ml.

Pricing and availability: the cost is $205, and this product is available on our website.

Comparison of Brands


Treatment of Orthovisc and Hyalgan can help give your patients relief from osteoarthritis pain for about six months after their initial three to four weekly injections.

By Hyalgan treatment, some patients may need to wait until they have had five injections to get pain relief. Your patients should continue to experience pain relief in their joints until around six months after their injection.

Speaking about Supartz and Monovisc, your patient will get relief for up to six months after they have completed this round of injections. They should return weekly for a total of three to five injections. 

The less time it takes Euflexxa. It requires only three, saving your patient the time and hassle of additional doctor visits.

So treatment ranges from a three-time infusion to weekly injections. The treatment can be repeated as necessary.

Side effects and risks

Common side effects of knee injections may include:

  • warmth, pain, redness, stiffness, bruising, or puffiness where the medicine was injected;
  • nausea, stomach pain;
  • trouble walking;
  • swelling in your hands or feet;
  • back pain, joint pain, muscle pain;
  • numbness or tingly feeling;
  • headache, dizziness.

These products are made from hyaluronic acid, a substance found within your patient’s body, so severe allergic reactions are rare. 

Cost and availability

The most expensive is Monovisc ($349). Orthovisc ($52) and Hyalgan ($44) are the cheapest. In the middle of the list are Euflexxa ($205) and Supartz ($299).


It is very important to store all hyaluronic acid injections in the original package, out of the reach of children, at a temperature not exceeding 25 °C.

The perfect place for buying the best hyaluronic acid injections

The best variety to buy hyaluronic injection for knees if you are a licensed doctor or another medical practitioner is by using a specialized shop, for instance, our website


Hyaluronan is found in the natural synovial fluid in joints, and it helps to lubricate joints and serves as a shock absorber. When Hyaluronic acid is injected, it may help lubricate a joint and increase its mobility. 

All described hyaluronic acid knee injections treat pain in joint inflammation patients. It is usually used in patients who have not responded to other treatments such as acetaminophen, exercise, or physical therapy.

Injected forms of hyaluronic acid for joint injection include Euflexxa, Hyalgan, Orthovisc, Supartz, and Synvisc. 

In this article, we reviewed all the popular hyaluronic knee injections, and you can choose the most appropriate ones for your patients.


  1. WebMD Editorial Contributors (2021). What Are the Treatments for Osteoarthritis? Medically Reviewed by Minesh Khatri, MD.
  2. Sunhee Jang, Kijun Lee, Ji Hyeon Ju (2021). Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee. International Journal of Molecular Sciences. 
  3. Søren T Skou, Ewa M Roos (2019). Physical therapy for patients with knee and hip osteoarthritis: supervised, active treatment is the current best practice. Clinical and experimental rheumatology.
  4. Jia Zhu Tang, Ming Jun Nie, Jian Zhong Zhao, Guang Cheng Zhang, Qing Zhang, and Bo Wang (2020). Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis. Journal of Orthopaedic Surgery and Research.
  5. Alessandro Di Martino, MD, Berardo Di Matteo, MD, Tiziana Papio, BcD Tentoni, MD, Filippo Selleri, MD, Annarita Cenacchi, MD, Elizaveta Kon, MD, and Giuseppe Filardo, MD, PhD (2018). Platelet-Rich Plasma Versus Hyaluronic Acid Injections for the Treatment of Knee Osteoarthritis: Results at 5 Years of a Double-Blind, Randomized Controlled Trial. The American journal of sports medicine.
  6. Cyrus Cooper, François Rannou, Pascal Richette, Olivier Bruyère, Nasser Al Daghri, Roy D. Altman, Maria Luisa Brandi, Sabine Collaud Basset, Gabriel Herrero Beaumont, Alberto Migliore, Karel Pavelka, Daniel Uebelhart, nand Jean Yves Reginster (2017). Use of Intraarticular Hyaluronic Acid in the Management of Knee Osteoarthritis in Clinical Practice. Arthritis Care Res (Hoboken).



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