DEPO-PROVERA®

Depo-Provera CI is a progestin indicated for use by females of reproductive potential to prevent pregnancy. Limitations of Use: The use of Depo-Provera CI is not recommended as a long-term (i.e., longer than 2 years) birth control method unless other options are considered inadequate.

Depo-Provera CI is a progestin hormone birth control method that is given by injection (a shot) to prevent pregnancy.

Depo-Provera CI contains medroxyprogesterone acetate, a derivative of progesterone, as its active ingredient. Medroxyprogesterone acetate is active by the parenteral and oral routes of administration. It is a white to off-white; odorless crystalline powder that is stable in air and that melts between 200°C and 210°C. It is freely soluble in chloroform, soluble in acetone and dioxane, sparingly soluble in alcohol and methanol, slightly soluble in ether, and insoluble in water.

1. Contraindications

   • Known or suspected pregnancy or as a diagnostic test for pregnancy.
   • Active thrombophlebitis, or current or past history of thromboembolic disorders, or cerebral vascular disease.
   • Known or suspected malignancy of breast.
   • Known hypersensitivity to Depo-Provera CI (medroxyprogesterone acetate or any of its other ingredients).
   • Significant liver disease.
   • Undiagnosed vaginal bleeding.

2. After-care

   • Advise patients at the beginning of treatment that their menstrual cycle may be disrupted and that irregular and unpredictable bleeding or spotting results, and that this usually decreases to the point of amenorrhea as treatment with Depo-Provera CI continues, without other therapy being required.
   • Counsel patients about the possible increased risk of breast cancer in women who use Depo-Provera CI.
   • Counsel patients that this product does not protect against HIV infection (AIDS) and other sexually transmitted diseases.
   • Counsel patients on Warnings and Precautions associated with use of Depo-Provera CI.